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    Unc5c unc-5 netrin receptor C [ Mus musculus (house mouse) ]

    Gene ID: 22253, updated on 20-Jul-2021

    Summary

    Official Symbol
    Unc5cprovided by MGI
    Official Full Name
    unc-5 netrin receptor Cprovided by MGI
    Primary source
    MGI:MGI:1095412
    See related
    Ensembl:ENSMUSG00000059921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    rcm; Unc5h; Unc5h3; B130051O18Rik
    Expression
    Biased expression in cerebellum adult (RPKM 4.5), limb E14.5 (RPKM 4.2) and 11 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Unc5c in Genome Data Viewer
    Location:
    3 H1; 3 65.57 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (141171325..141540685)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (141465564..141834924)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (141128528..141497886)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930590L14 gene Neighboring gene predicted gene, 32875 Neighboring gene pyruvate dehydrogenase E1 alpha 2 Neighboring gene predicted gene 15689 Neighboring gene bone morphogenetic protein receptor, type 1B Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene 3 Neighboring gene PDZ and LIM domain 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Transgenic (2)  1 citation
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 6030473H24

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables netrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables netrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables netrin receptor activity involved in chemorepulsion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    netrin receptor UNC5C
    Names
    UNC-5 homolog 3
    rostral cerebellar malformation protein
    unc-5 homolog C
    unc5 homolog 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293561.1NP_001280490.1  netrin receptor UNC5C isoform 1 precursor

      See identical proteins and their annotated locations for NP_001280490.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC157492, AC158552, AC170085, AK141181
      Consensus CDS
      CCDS80034.1
      UniProtKB/TrEMBL
      Q3UQ08, Q3URW2
      Related
      ENSMUSP00000074758.4, ENSMUST00000075282.10
      Conserved Domains (5) summary
      smart00218
      Location:547650
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00209
      Location:263314
      TSP1; Thrombospondin type 1 repeats
      pfam07679
      Location:169257
      I-set; Immunoglobulin I-set domain
      cd08799
      Location:863945
      Death_UNC5C; Death domain found in Uncoordinated-5C
      cl11960
      Location:171257
      Ig; Immunoglobulin domain
    2. NM_009472.4NP_033498.1  netrin receptor UNC5C isoform 2 precursor

      See identical proteins and their annotated locations for NP_033498.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC157492, AC158552, AC170085
      Consensus CDS
      CCDS17873.1
      UniProtKB/Swiss-Prot
      O08747
      Related
      ENSMUSP00000101843.3, ENSMUST00000106236.9
      Conserved Domains (5) summary
      smart00218
      Location:528631
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00209
      Location:263314
      TSP1; Thrombospondin type 1 repeats
      pfam07679
      Location:169257
      I-set; Immunoglobulin I-set domain
      cd08799
      Location:844926
      Death_UNC5C; Death domain found in Uncoordinated-5C
      cl11960
      Location:171257
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      141171325..141540685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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