Dmrt3 doublesex and mab-3 related transcription factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmrt3provided by MGI
Official Full Name: doublesex and mab-3 related transcription factor 3provided by MGI
Primary source: MGI:MGI:2449470
See related: Ensembl:ENSMUSG00000042372 AllianceGenome:MGI:2449470
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including adult walking behavior; transmission of nerve impulse; and ventral spinal cord interneuron specification. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and nose. Orthologous to human DMRT3 (doublesex and mab-3 related transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 2.1), CNS E14 (RPKM 1.6) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 B; 19 20.5 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (25587609..25601285)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (25610246..25623921)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.
Title: Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.
Present study provides novel insights on the character of spinal Dmrt3-derived neurons, data demonstrating that these neurons participate in locomotor coordination.
Title: Characterization of Dmrt3-Derived Neurons Suggest a Role within Locomotor Circuits.
Study suggests that DMRT3/5 function with EMX2 in positioning the pallial-subpallial boundary by antagonizing the ventral homeobox transcription factor GSX2.
Title: DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors.
Finely tuned levels of DMRT5, together with DMRT3, regulate patterning of the cerebral cortex.
Title: DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation.
examination of wild-type and Dmrt3-null mice demonstrates that Dmrt3 is expressed in the dI6 subdivision of spinal cord neurons, takes part in neuronal specification within this subdivision, and is critical for the normal development of a coordinated loco
Title: Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Markers

Dmrt3 (e-PCR), detects polymorphism
- UniSTS:474725

Dmrt3 (e-PCR), detects polymorphism
- UniSTS:547208

Dmrt3 (e-PCR), detects polymorphism
- UniSTS:257211

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in male sex differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sex differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventral spinal cord interneuron specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: doublesex- and mab-3-related transcription factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177360.3 → NP_796334.2 doublesex- and mab-3-related transcription factor 3

See identical proteins and their annotated locations for NP_796334.2

Status: VALIDATED

Source sequence(s)

AF541936, BC052041

Consensus CDS

CCDS29718.1

UniProtKB/Swiss-Prot

Q80WT2, Q8CGX1

Related

ENSMUSP00000046812.5, ENSMUST00000048935.6

Conserved Domains (2) summary

cd14419
Location:253 → 295

CUE_DMA_DMRTA3; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3)

pfam00751
Location:25 → 71

DM; DM DNA binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

25587609..25601285

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527066.4 → XP_006527129.1 doublesex- and mab-3-related transcription factor 3 isoform X1

See identical proteins and their annotated locations for XP_006527129.1

UniProtKB/Swiss-Prot

Q80WT2, Q8CGX1

Conserved Domains (2) summary

cd14419
Location:253 → 295

CUE_DMA_DMRTA3; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3)

pfam00751
Location:25 → 71

DM; DM DNA binding domain