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    Klrc2 killer cell lectin-like receptor subfamily C, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 16642, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Klrc2provided by MGI
    Official Full Name
    killer cell lectin-like receptor subfamily C, member 2provided by MGI
    Primary source
    MGI:MGI:1336162
    See related
    Ensembl:ENSMUSG00000052736 AllianceGenome:MGI:1336162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NKG2C
    Summary
    Predicted to enable MHC class I protein complex binding activity; activating MHC class Ib receptor activity; and protein antigen binding activity. Predicted to be involved in natural killer cell mediated immunity; positive regulation of natural killer cell degranulation; and stimulatory C-type lectin receptor signaling pathway. Located in external side of plasma membrane. Orthologous to human KLRC2 (killer cell lectin like receptor C2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    6 F3; 6 63.44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129626565..129637700, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129649602..129660737, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor subfamily K, member 1 Neighboring gene killer cell lectin-like receptor subfamily C, member 3 Neighboring gene killer cell lectin-like receptor subfamily C, member 1 Neighboring gene PQ loop repeat containing pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of mouse NKG2A and C. Silver ET, et al. Immunogenetics, 1999 Jul. PMID 10369936
    2. Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells. Lohwasser S, et al. Eur J Immunol, 1999 Mar. PMID 10092077
    3. Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing. Ferez M, et al. J Exp Med, 2021 May 3. PMID 33765134, Free PMC Article
    4. Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. Vance RE, et al. J Exp Med, 1999 Dec 20. PMID 10601355, Free PMC Article
    5. Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity. Saether PC, et al. J Immunol, 2011 Dec 15. PMID 22084441

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rat and mouse CD94/NKG2C heterodimers bind efficiently to both adadptor proteins DAP12 and DAP10; this binding activity is critically dependent on the transmembrane lysine residue of CD94.
      Title: Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class I protein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables activating MHC class Ib receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of natural killer cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of natural killer cell activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in stimulatory C-type lectin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    killer cell lectin-like receptor subfamily C, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098669.1 → NP_001092139.1  killer cell lectin-like receptor subfamily C, member 2 isoform 2

      See identical proteins and their annotated locations for NP_001092139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing one of the internal coding exons found in transcript variant 1. It maintains the same reading frame, and encodes a shorter isoform (2, also known as NKG2C2) lacking an internal protein segment compared to isoform 1.
      Source sequence(s)
      AF106011
      Consensus CDS
      CCDS51924.1
      UniProtKB/TrEMBL
      D3YXP2, Q9WVJ7
      Related
      ENSMUSP00000113970.2, ENSMUST00000118401.8
      Conserved Domains (2) summary
      cd03593
      Location:97 → 209
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      PHA03097
      Location:65 → 212
      PHA03097; C-type lectin-like protein; Provisional

    2. NM_010653.4 → NP_034783.3  killer cell lectin-like receptor subfamily C, member 2 isoform 1

      See identical proteins and their annotated locations for NP_034783.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1, also known as NKG2C1).
      Source sequence(s)
      AF109785
      Consensus CDS
      CCDS51925.1
      UniProtKB/TrEMBL
      D3YXP2, Q9WTJ9
      Related
      ENSMUSP00000112733.2, ENSMUST00000119533.2
      Conserved Domains (1) summary
      cd03593
      Location:122 → 234
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129626565..129637700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165892.1 → XP_036021785.1  killer cell lectin-like receptor subfamily C, member 2 isoform X2

      UniProtKB/TrEMBL
      D3YXP2, Q9WTJ9
      Related
      ENSMUSP00000107688.3, ENSMUST00000112057.9
      Conserved Domains (1) summary
      cd03593
      Location:122 → 234
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. XM_017321419.1 → XP_017176908.1  killer cell lectin-like receptor subfamily C, member 2 isoform X1

      UniProtKB/TrEMBL
      A1L3Q6
      Related
      ENSMUSP00000071813.5, ENSMUST00000071920.11
      Conserved Domains (1) summary
      cd03593
      Location:130 → 242
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    Nucleotide Protein Strain
    Heading Accession and Version

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