Itgb2 integrin beta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgb2provided by MGI
Official Full Name: integrin beta 2provided by MGI
Primary source: MGI:MGI:96611
See related: Ensembl:ENSMUSG00000000290 AllianceGenome:MGI:96611
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2E6; LAD; Cd18; Lfa1; MF17; LCAMB
Summary: Enables amyloid-beta binding activity and complement component C3b binding activity. Contributes to cargo receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; endocytosis; and positive regulation of leukocyte adhesion to vascular endothelial cell. Acts upstream of or within several processes, including activated T cell proliferation; integrin-mediated signaling pathway; and leukocyte migration. Located in external side of plasma membrane and membrane raft. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; hemolymphoid system; and nervous system. Used to study leukocyte adhesion deficiency 1 and psoriasis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 72.3), spleen adult (RPKM 63.3) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (77366164..77401542)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (77530329..77565708)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury.
Title: B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury.
Distinct bidirectional regulation of LFA1 and alpha4beta7 by Rap1 and integrin adaptors in T cells under shear flow.
Title: Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.
LFA-1 knockout inhibited the tumor growth and is correlated with treg cells.
Title: LFA-1 knockout inhibited the tumor growth and is correlated with treg cells.
LFA-1/ICAM-1 Adhesion Pathway Mediates the Homeostatic Migration of Lymphocytes from Peripheral Tissues into Lymph Nodes through Lymphatic Vessels.
Title: LFA-1/ICAM-1 Adhesion Pathway Mediates the Homeostatic Migration of Lymphocytes from Peripheral Tissues into Lymph Nodes through Lymphatic Vessels.
Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent beta2 integrin activation in monocytes.
Title: Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes.
Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18.
Title: Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18.
Regulation of CD18 stability by SIGIRR-modulated ubiquitination: new insights into the relationship between innate immune response and acute lung injury.
Title: Regulation of CD18 stability by SIGIRR-modulated ubiquitination: new insights into the relationship between innate immune response and acute lung injury.
The Role of LFA-1 for the Differentiation and Function of Regulatory T Cells-Lessons Learned from Different Transgenic Mouse Models.
Title: The Role of LFA-1 for the Differentiation and Function of Regulatory T Cells-Lessons Learned from Different Transgenic Mouse Models.
CD18 controls the development and activation of monocyte-to-macrophage axis during chronic schistosomiasis.
Title: CD18 controls the development and activation of monocyte-to-macrophage axis during chronic schistosomiasis.
LFA-1/ ICAM-1 promotes NK cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model.
Title: LFA-1/ ICAM-1 promotes NK cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model.

Submit: New GeneRIF Correction See all GeneRIFs (194)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Chemically induced (ENU) (5)
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itgb2 (e-PCR), detects polymorphism
- UniSTS:143630

Itgb2 (e-PCR), detects polymorphism
- UniSTS:259095

Itgb2 (e-PCR), detects polymorphism
- UniSTS:259623

D10Mit92 (e-PCR), detects polymorphism
- UniSTS:126277

Itgb2 (e-PCR), detects polymorphism
- UniSTS:256397

AI528527 (e-PCR)
- UniSTS:185843

X14951 (e-PCR)
- UniSTS:159995

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ICAM-3 receptor activity	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to cargo receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables complement component C3b binding	IGI Inferred from Genetic Interaction more info	PubMed
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid-beta clearance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular extravasation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in neutrophil migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin alphaL-beta2 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphaM-beta2 complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: integrin beta-2

Names: Mac-1 beta; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement receptor C3 subunit beta; lymphocyte function associated antigen 1; macrophage antigen-1 beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008404.5 → NP_032430.2 integrin beta-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_032430.2

Status: VALIDATED

Source sequence(s)

AC153830

Consensus CDS

CCDS23956.1

UniProtKB/Swiss-Prot

P11835, Q64482

UniProtKB/TrEMBL

Q542I8

Related

ENSMUSP00000000299.8, ENSMUST00000000299.14

Conserved Domains (3) summary

pfam00362
Location:32 → 447

Integrin_beta; Integrin, beta chain

pfam07965
Location:626 → 700

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:727 → 767

Integrin_b_cyt; Integrin beta cytoplasmic domain

RNA

NR_157228.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AK161236, AK169587, BY787094

Related

ENSMUST00000156644.8
NR_157229.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153830, AK161236, BY787094

Related

ENSMUST00000153541.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

77366164..77401542

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513272.4 → XP_006513335.1 integrin beta-2 isoform X1

See identical proteins and their annotated locations for XP_006513335.1

UniProtKB/Swiss-Prot

P11835, Q64482

Conserved Domains (4) summary

smart00187
Location:15 → 369

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:548 → 622

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:649 → 689

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:369 → 398

I-EGF_1; Integrin beta epidermal growth factor like domain 1
XM_006513271.4 → XP_006513334.1 integrin beta-2 isoform X1

See identical proteins and their annotated locations for XP_006513334.1

UniProtKB/Swiss-Prot

P11835, Q64482

Conserved Domains (4) summary

smart00187
Location:15 → 369

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:548 → 622

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:649 → 689

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:369 → 398

I-EGF_1; Integrin beta epidermal growth factor like domain 1
XM_017313814.2 → XP_017169303.1 integrin beta-2 isoform X1

UniProtKB/Swiss-Prot

P11835, Q64482

Conserved Domains (4) summary

smart00187
Location:15 → 369

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:548 → 622

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:649 → 689

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:369 → 398

I-EGF_1; Integrin beta epidermal growth factor like domain 1