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    Nrep neuronal regeneration related protein [ Mus musculus (house mouse) ]

    Gene ID: 27528, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nrepprovided by MGI
    Official Full Name
    neuronal regeneration related proteinprovided by MGI
    Primary source
    MGI:MGI:99444
    See related
    Ensembl:ENSMUSG00000042834 AllianceGenome:MGI:99444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Harp; P311; PTZ17; SEZ17; D0H4S114
    Summary
    Acts upstream of or within regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including lung; nervous system; otocyst; and retina. Orthologous to human NREP (neuronal regeneration related protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 316.2), whole brain E14.5 (RPKM 274.8) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 B1; 18 18.18 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (33570072..33597444, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (33437019..33464365, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41683 Neighboring gene VISTA enhancer mm76 Neighboring gene predicted gene, 46640 Neighboring gene STARR-seq mESC enhancer starr_44167 Neighboring gene O-sialoglycoprotein endopeptidase pseudogene Neighboring gene STARR-seq mESC enhancer starr_44168 Neighboring gene predicted gene 10549 Neighboring gene predicted gene, 41684 Neighboring gene VISTA enhancer mm15 Neighboring gene STARR-seq mESC enhancer starr_44170 Neighboring gene STARR-seq mESC enhancer starr_44172 Neighboring gene predicted gene, 54016

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. P311, a novel intrinsically disordered protein, regulates adipocyte development. Nunez S, et al. Biochem Biophys Res Commun, 2019 Jul 12. PMID 31146912, Free PMC Article
    2. Reconstruction and Functional Annotation of P311 Protein-Protein Interaction Network Reveals Its New Functions. Wang S, et al. Front Genet, 2019. PMID 30838032, Free PMC Article
    3. P311 Deficiency Leads to Attenuated Angiogenesis in Cutaneous Wound Healing. Wang S, et al. Front Physiol, 2017. PMID 29270129, Free PMC Article
    4. P311 modulates hepatic stellate cells migration. Guimarães EL, et al. Liver Int, 2015 Apr. PMID 25243526
    5. Blood pressure homeostasis is maintained by a P311-TGF-β axis. Badri KR, et al. J Clin Invest, 2013 Oct. PMID 24091331, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P311 regulates distal lung development via its interaction with several binding proteins.
      Title: P311 regulates distal lung development via its interaction with several binding proteins.
    2. Butyrate alleviates diabetic kidney disease by mediating the miR-7a-5p/P311/TGF-beta1 pathway.
      Title: Butyrate alleviates diabetic kidney disease by mediating the miR-7a-5p/P311/TGF-β1 pathway.
    3. Neuronal regeneration related protein (P311) overexpression enhanced adipogenic differentiation of 3T3-L1 cells.
      Title: P311, a novel intrinsically disordered protein, regulates adipocyte development.
    4. The essential function of P311 in TGF-beta-mediated lung fibrosis.P311 regulates TGF-beta1, TGF-beta2 and TGF-beta3 translation in the lung fibrosis.
      Title: P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-β1, -β2, and -β3 Translation.
    5. P311 is a novel TGFbeta1/Smad signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
      Title: P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression.
    6. P311 could accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cell through RhoA and Rac1 activation.
      Title: P311 Accelerates Skin Wound Reepithelialization by Promoting Epidermal Stem Cell Migration Through RhoA and Rac1 Activation.
    7. These studies demonstrate that P311 is required for the production of normal cutaneous scars
      Title: Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar Collagen Deposition and Tensile Strength due to Impaired Transforming Growth Factor-β1 to -β3 Translation.
    8. P311 plays a key role in renal fibrosis via TGFbeta1/Smad signaling, which could be a novel target for the management of renal fibrosis.
      Title: P311 promotes renal fibrosis via TGFβ1/Smad signaling.
    9. P311 is central to reactive oxygen species-mediated hepatic stellate cell migration induced by different chemokines.
      Title: P311 modulates hepatic stellate cells migration.
    10. P311 is the first protein identified to modulate TGF-beta translation and the first pan-regulator of TGF-beta expression.
      Title: Blood pressure homeostasis is maintained by a P311-TGF-β axis.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuronal regeneration-related protein
    Names
    high-altitude regulated protein
    neuronal protein 3.1
    protein p311

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109988.1 → NP_001103458.1  neuronal regeneration-related protein

      See identical proteins and their annotated locations for NP_001103458.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC115117, AK020629
      Consensus CDS
      CCDS37756.1
      UniProtKB/Swiss-Prot
      Q07475
      UniProtKB/TrEMBL
      Q542Q5
      Related
      ENSMUSP00000130297.2, ENSMUST00000168890.2
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    2. NM_001109989.2 → NP_001103459.1  neuronal regeneration-related protein

      See identical proteins and their annotated locations for NP_001103459.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC115117, CX768079
      Consensus CDS
      CCDS37756.1
      UniProtKB/Swiss-Prot
      Q07475
      UniProtKB/TrEMBL
      Q542Q5
      Related
      ENSMUSP00000157912.2, ENSMUST00000237066.2
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    3. NM_001267717.1 → NP_001254646.1  neuronal regeneration-related protein

      See identical proteins and their annotated locations for NP_001254646.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC115117
      Consensus CDS
      CCDS37756.1
      UniProtKB/Swiss-Prot
      Q07475
      UniProtKB/TrEMBL
      Q542Q5
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    4. NM_053078.4 → NP_444308.1  neuronal regeneration-related protein

      See identical proteins and their annotated locations for NP_444308.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AK048361, AV321356, CJ148521
      Consensus CDS
      CCDS37756.1
      UniProtKB/Swiss-Prot
      Q07475
      UniProtKB/TrEMBL
      Q542Q5
      Related
      ENSMUSP00000058132.9, ENSMUST00000051087.16
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      33570072..33597444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250488.2 → XP_030106348.1  neuronal regeneration-related protein isoform X1

      UniProtKB/Swiss-Prot
      Q07475
      UniProtKB/TrEMBL
      Q542Q5
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    2. XM_036161164.1 → XP_036017057.1  neuronal regeneration-related protein isoform X1

      UniProtKB/Swiss-Prot
      Q07475
      UniProtKB/TrEMBL
      Q542Q5
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07475.1 GenPept UniProtKB/Swiss-Prot:Q07475

    Gene LinkOut

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