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    Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 12406, updated on 7-Jun-2021

    Summary

    Official Symbol
    Serpinh1provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade H, member 1provided by MGI
    Primary source
    MGI:MGI:88283
    See related
    Ensembl:ENSMUSG00000070436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    J6; co; Cbp; Hsp; Ser; gp4; Cbp1; Cbp2; gp46; Hsp47; BERF-1; Serpinh2
    Expression
    Broad expression in limb E14.5 (RPKM 483.4), ovary adult (RPKM 448.6) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Serpinh1 in Genome Data Viewer
    Location:
    7; 7 E1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (98994582..99002480, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99345375..99353239, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (106493885..106501749, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26705 Neighboring gene microtubule-associated protein 6 Neighboring gene predicted gene, 40449 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5 Neighboring gene kelch-like 35

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serpin H1
    Names
    47 kDa heat shock protein
    beta enolase repressor factor 1
    collagen binding protein 1
    colligin
    serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1
    serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2
    serine protease inhibitor J6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111043.1NP_001104513.1  serpin H1 precursor

      See identical proteins and their annotated locations for NP_001104513.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AV300388, BB686988, BC085143, CA751137
      Consensus CDS
      CCDS21480.1
      UniProtKB/Swiss-Prot
      P19324
      Related
      ENSMUSP00000147064.2, ENSMUST00000207849.2
      Conserved Domains (1) summary
      cd02046
      Location:35416
      serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1
    2. NM_001111044.1NP_001104514.1  serpin H1 precursor

      See identical proteins and their annotated locations for NP_001104514.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK077937, AV300388, BB686988, CA751137
      Consensus CDS
      CCDS21480.1
      UniProtKB/Swiss-Prot
      P19324
      Related
      ENSMUSP00000091706.5, ENSMUST00000094154.6
      Conserved Domains (1) summary
      cd02046
      Location:35416
      serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1
    3. NM_001285776.1NP_001272705.1  serpin H1 precursor

      See identical proteins and their annotated locations for NP_001272705.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC158748, AK029080
      Consensus CDS
      CCDS21480.1
      UniProtKB/Swiss-Prot
      P19324
      Related
      ENSMUSP00000146969.2, ENSMUST00000208119.2
      Conserved Domains (1) summary
      cd02046
      Location:35416
      serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1
    4. NM_009825.2NP_033955.2  serpin H1 precursor

      See identical proteins and their annotated locations for NP_033955.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK031457, AV300388, BB686988, CA751137
      Consensus CDS
      CCDS21480.1
      UniProtKB/Swiss-Prot
      P19324
      Related
      ENSMUSP00000126390.2, ENSMUST00000169437.9
      Conserved Domains (1) summary
      cd02046
      Location:35416
      serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      98994582..99002480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507279.5XP_006507342.1  serpin H1 isoform X1

      See identical proteins and their annotated locations for XP_006507342.1

      UniProtKB/Swiss-Prot
      P19324
      Conserved Domains (1) summary
      cd02046
      Location:35416
      serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1
    2. XM_006507278.5XP_006507341.1  serpin H1 isoform X1

      See identical proteins and their annotated locations for XP_006507341.1

      UniProtKB/Swiss-Prot
      P19324
      Conserved Domains (1) summary
      cd02046
      Location:35416
      serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1
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