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    Larp1b La ribonucleoprotein 1B [ Mus musculus (house mouse) ]

    Gene ID: 214048, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Larp1bprovided by MGI
    Official Full Name
    La ribonucleoprotein 1Bprovided by MGI
    Primary source
    MGI:MGI:1914604
    See related
    Ensembl:ENSMUSG00000025762 AllianceGenome:MGI:1914604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Larp2; 1700108L22Rik; 4933421B21Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of translation. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human LARP1B (La ribonucleoprotein 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 7.9), small intestine adult (RPKM 2.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 B; 3 19.61 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (40904198..40994642)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (40949770..41040207)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6430590A07 gene Neighboring gene abhydrolase domain containing 18 Neighboring gene FUN14 domain containing 2B Neighboring gene STARR-positive B cell enhancer ABC_E7910 Neighboring gene STARR-seq mESC enhancer starr_07475 Neighboring gene predicted gene, 22043 Neighboring gene predicted gene 42437 Neighboring gene STARR-seq mESC enhancer starr_07477 Neighboring gene STARR-positive B cell enhancer mm9_chr3:40886815-40887116 Neighboring gene progesterone receptor membrane component 2 Neighboring gene STARR-seq mESC enhancer starr_07478 Neighboring gene STARR-seq mESC enhancer starr_07480 Neighboring gene STARR-seq mESC enhancer starr_07481 Neighboring gene predicted gene, 40038

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10378, MGC38253, MGC117760

    General protein information

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    Preferred Names
    la-related protein 1B
    Names
    La ribonucleoprotein domain family, member 1B
    La ribonucleoprotein domain family, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040399.3 → NP_001035489.2  la-related protein 1B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102794
      UniProtKB/TrEMBL
      F6U5V1
      Related
      ENSMUSP00000037127.8, ENSMUST00000048490.13
      Conserved Domains (1) summary
      cd08038
      Location:422 → 494
      LARP_2; La RNA-binding domain of La-related protein 2

    2. NM_001368221.1 → NP_001355150.1  la-related protein 1B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102794
      Consensus CDS
      CCDS38423.1
      UniProtKB/TrEMBL
      A0A0A6YWC2, Q8BVS5
      Related
      ENSMUSP00000141487.2, ENSMUST00000191805.7
      Conserved Domains (1) summary
      cd08038
      Location:216 → 288
      LARP_2; La RNA-binding domain of La-related protein 2

    3. NM_001368222.1 → NP_001355151.1  la-related protein 1B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102794
      Consensus CDS
      CCDS89623.1
      UniProtKB/TrEMBL
      Q3TQS1, Q8BVS5
      Related
      ENSMUSP00000142106.2, ENSMUST00000191872.6

    4. NM_001394999.1 → NP_001381928.1  la-related protein 1B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102794
      UniProtKB/TrEMBL
      A0A0A6YWC2, Q8BVS5
      Conserved Domains (1) summary
      cd08038
      Location:216 → 288
      LARP_2; La RNA-binding domain of La-related protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      40904198..40994642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163009.1 → XP_036018902.1  la-related protein 1B isoform X3

    2. XM_036163004.1 → XP_036018897.1  la-related protein 1B isoform X1

      UniProtKB/TrEMBL
      F6U5V1
      Conserved Domains (1) summary
      cd08038
      Location:422 → 494
      LARP_2; La RNA-binding domain of La-related protein 2

    3. XM_036163005.1 → XP_036018898.1  la-related protein 1B isoform X1

      UniProtKB/TrEMBL
      F6U5V1
      Conserved Domains (1) summary
      cd08038
      Location:422 → 494
      LARP_2; La RNA-binding domain of La-related protein 2

    4. XM_030252544.2 → XP_030108404.2  la-related protein 1B isoform X1

      UniProtKB/TrEMBL
      F6U5V1
      Conserved Domains (1) summary
      cd08038
      Location:422 → 494
      LARP_2; La RNA-binding domain of La-related protein 2

    5. XM_036163006.1 → XP_036018899.1  la-related protein 1B isoform X1

      UniProtKB/TrEMBL
      F6U5V1
      Conserved Domains (1) summary
      cd08038
      Location:422 → 494
      LARP_2; La RNA-binding domain of La-related protein 2

    6. XM_036163008.1 → XP_036018901.1  la-related protein 1B isoform X2

      UniProtKB/TrEMBL
      A0A0A6YWC2, Q8BVS5
      Conserved Domains (1) summary
      cd08038
      Location:216 → 288
      LARP_2; La RNA-binding domain of La-related protein 2

    7. XM_036163007.1 → XP_036018900.1  la-related protein 1B isoform X2

      UniProtKB/TrEMBL
      A0A0A6YWC2, Q8BVS5
      Conserved Domains (1) summary
      cd08038
      Location:216 → 288
      LARP_2; La RNA-binding domain of La-related protein 2

    8. XM_036163010.1 → XP_036018903.1  la-related protein 1B isoform X4

      UniProtKB/TrEMBL
      Q9D423
      Conserved Domains (1) summary
      smart00684
      Location:119 → 157
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

    9. XM_036163011.1 → XP_036018904.1  la-related protein 1B isoform X5

      UniProtKB/TrEMBL
      Q9D423
      Related
      ENSMUSP00000096721.4, ENSMUST00000099121.10
      Conserved Domains (1) summary
      smart00684
      Location:119 → 157
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027663.1: Suppressed sequence

      Description
      NM_027663.1: This RefSeq was suppressed temporarily because it represents a fragment of an Larp2 mRNA.

    2. NM_145988.1: Suppressed sequence

      Description
      NM_145988.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version

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