Las1l LAS1-like (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Las1lprovided by MGI
Official Full Name: LAS1-like (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:1923380
See related: Ensembl:ENSMUSG00000057421 AllianceGenome:MGI:1923380
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810030A06Rik; 5830482G23Rik
Summary: Predicted to enable endonuclease activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be located in cytoplasm and nucleus. Predicted to be part of MLL1 complex and preribosome, large subunit precursor. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 15.5), CNS E14 (RPKM 8.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X C3; X 42.58 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (94963651..95000580, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (95920045..95956974, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC]
Title: Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in maturation of 5.8S rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Las1 complex	IEA Inferred from Electronic Annotation more info
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribosomal biogenesis protein LAS1L

Names: endoribonuclease LAS1L; protein LAS1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374717.1 → NP_001361646.1 ribosomal biogenesis protein LAS1L isoform 1

Status: VALIDATED

Source sequence(s)

BX005184

UniProtKB/Swiss-Prot

A2BE28, A2BE30, Q6KAR5, Q8C742

Related

ENSMUSP00000109495.3, ENSMUST00000113864.3

Conserved Domains (1) summary

pfam04031
Location:28 → 172

Las1; Las1-like
NM_152822.3 → NP_690035.2 ribosomal biogenesis protein LAS1L isoform 2

See identical proteins and their annotated locations for NP_690035.2

Status: VALIDATED

Source sequence(s)

BC141155, BM570808, BY059480

Consensus CDS

CCDS30287.1

UniProtKB/Swiss-Prot

A2BE28

Related

ENSMUSP00000078901.7, ENSMUST00000079987.13

Conserved Domains (1) summary

pfam04031
Location:28 → 172

Las1; Las1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

94963651..95000580 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528336.2 → XP_006528399.1 ribosomal biogenesis protein LAS1L isoform X3

Conserved Domains (1) summary

pfam04031
Location:28 → 172

Las1; Las1-like
XM_017318635.2 → XP_017174124.1 ribosomal biogenesis protein LAS1L isoform X2

Conserved Domains (1) summary

pfam04031
Location:28 → 172

Las1; Las1-like
XM_006528335.4 → XP_006528398.1 ribosomal biogenesis protein LAS1L isoform X1

Conserved Domains (1) summary

pfam04031
Location:28 → 172

Las1; Las1-like