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    Kbtbd7 kelch repeat and BTB (POZ) domain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 211255, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Kbtbd7provided by MGI
    Official Full Name
    kelch repeat and BTB (POZ) domain containing 7provided by MGI
    Primary source
    MGI:MGI:2685141
    See related
    Ensembl:ENSMUSG00000043881 AllianceGenome:MGI:2685141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm295; 1110008P08Rik
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and regulation of Rac protein signal transduction. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in embryo. Orthologous to human KBTBD7 (kelch repeat and BTB domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    See Kbtbd7 in Genome Data Viewer
    Location:
    14 D3; 14 42.65 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79663951..79668479)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79426511..79431039)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79691968-79692228 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79693274-79693461 Neighboring gene regulator of cell cycle Neighboring gene N(alpha)-acetyltransferase 16, NatA auxiliary subunit Neighboring gene STARR-positive B cell enhancer ABC_E11576 Neighboring gene STARR-positive B cell enhancer ABC_E4121 Neighboring gene STARR-positive B cell enhancer ABC_E7342 Neighboring gene STARR-positive B cell enhancer ABC_E7343 Neighboring gene STARR-positive B cell enhancer ABC_E4122 Neighboring gene mitochondrial translational release factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E2429 Neighboring gene kelch repeat and BTB (POZ) domain containing 6 Neighboring gene WW domain binding protein 4 Neighboring gene E74 like ETS transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New TFII-I family target genes involved in embryonic development. Makeyev AV, et al. Biochem Biophys Res Commun, 2009 Sep 4. PMID 19527686, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch repeat and BTB domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024135.2 → NP_001019306.2  kelch repeat and BTB domain-containing protein 7

      See identical proteins and their annotated locations for NP_001019306.2

      Status: VALIDATED

      Source sequence(s)
      BC096019, CO045548
      Consensus CDS
      CCDS27298.1
      UniProtKB/TrEMBL
      G5E8C2, Q501K2
      Related
      ENSMUSP00000060768.8, ENSMUST00000061222.9
      Conserved Domains (5) summary
      smart00875
      Location:173 → 274
      BACK; BTB And C-terminal Kelch
      PHA03098
      Location:55 → 554
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:394 → 431
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:53 → 164
      BTB; BTB/POZ domain
      pfam01344
      Location:435 → 481
      Kelch_1; Kelch motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      79663951..79668479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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