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    Ccny cyclin Y [ Mus musculus (house mouse) ]

    Gene ID: 67974, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ccnyprovided by MGI
    Official Full Name
    cyclin Yprovided by MGI
    Primary source
    MGI:MGI:1915224
    See related
    Ensembl:ENSMUSG00000024286 AllianceGenome:MGI:1915224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700025H17Rik; 3110050L10Rik; 4631402G10Rik; 5730405I09Rik
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway and cell division. Predicted to be located in nucleus. Predicted to be part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; gut; liver; mammary gland; and spleen. Orthologous to human CCNY (cyclin Y). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 25.9), ovary adult (RPKM 20.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 A1; 18 4.91 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (9312304..9450188, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (9312304..9450154, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1632 Neighboring gene frizzled class receptor 8 Neighboring gene STARR-seq mESC enhancer starr_43772 Neighboring gene STARR-seq mESC enhancer starr_43773 Neighboring gene STARR-seq mESC enhancer starr_43774 Neighboring gene gap junction protein, delta 4 Neighboring gene STARR-positive B cell enhancer ABC_E7573 Neighboring gene STARR-seq mESC enhancer starr_43776 Neighboring gene predicted gene, 35458 Neighboring gene family with sequence similarity 76, member A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway. Seo J, et al. Mol Psychiatry, 2023 Mar. PMID 36434054, Free PMC Article
    2. The Candidate IBD Risk Gene CCNY Is Dispensable for Intestinal Epithelial Homeostasis. Molinas A, et al. Cells, 2021 Sep 6. PMID 34571979, Free PMC Article
    3. Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy. Hwang H, et al. Pharmacol Res, 2020 Oct. PMID 32739426
    4. Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production. An W, et al. PLoS One, 2015. PMID 26161966, Free PMC Article
    5. [Phosphorus-calcium metabolism in children under long-term anticonvulsant therapy]. Lluch Fernández MD, et al. An Esp Pediatr, 1991 Aug. PMID 1952457

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway.
      Title: Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway.
    2. Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
      Title: Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
    3. Here we show that Cyclin Y-like 1 (Ccnyl1) and Cyclin Y (Ccny) have overlapping function and are crucial for mouse embryonic development and mammary stem/progenitor cell functions. Double knockout of Ccnys results in embryonic lethality at E16.5
      Title: Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells.
    4. these results provide a new link between CCNY and lipid metabolism in mice.
      Title: Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production.
    5. CDK16 isolated from testis was unphosphorylated, interacted with CCNY, and exhibited kinase activity.
      Title: Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-Y
    Names
    cyclin fold protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026484.4 → NP_080760.2  cyclin-Y

      See identical proteins and their annotated locations for NP_080760.2

      Status: VALIDATED

      Source sequence(s)
      AC108777, AK014201, AK014507, AK028696, AW048376
      Consensus CDS
      CCDS29050.1
      UniProtKB/Swiss-Prot
      Q8BGU5, Q8CI87, Q9CYN5
      Related
      ENSMUSP00000050001.5, ENSMUST00000053917.6
      Conserved Domains (1) summary
      cd20540
      Location:166 → 262
      CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      9312304..9450188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250583.2 → XP_030106443.1  cyclin-Y isoform X2

      Conserved Domains (1) summary
      pfam00134
      Location:101 → 223
      Cyclin_N; Cyclin, N-terminal domain

    2. XM_030250584.2 → XP_030106444.1  cyclin-Y isoform X4

      Conserved Domains (1) summary
      cd20540
      Location:27 → 123
      CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

    3. XM_036161266.1 → XP_036017159.1  cyclin-Y isoform X4

      Conserved Domains (1) summary
      cd20540
      Location:27 → 123
      CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

    4. XM_030250582.1 → XP_030106442.1  cyclin-Y isoform X1

      Conserved Domains (1) summary
      pfam00134
      Location:89 → 211
      Cyclin_N; Cyclin, N-terminal domain

    5. XM_036161265.1 → XP_036017158.1  cyclin-Y isoform X3

      Conserved Domains (1) summary
      cl40454
      Location:166 → 193
      CYCLIN_SF; Cyclin box fold superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGU5.1 GenPept UniProtKB/Swiss-Prot:Q8BGU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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