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    Ift25 intraflagellar transport 25 [ Mus musculus (house mouse) ]

    Gene ID: 72938, updated on 9-May-2024

    Summary

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    Official Symbol
    Ift25provided by MGI
    Official Full Name
    intraflagellar transport 25provided by MGI
    Primary source
    MGI:MGI:1920188
    See related
    Ensembl:ENSMUSG00000063172 AllianceGenome:MGI:1920188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PP25; Hspb11; 2900042B11Rik
    Summary
    Predicted to enable metal ion binding activity. Involved in kidney development; smoothened signaling pathway; and spermatogenesis. Acts upstream of or within animal organ development; left/right axis specification; and skeletal system development. Located in centrosome and cilium. Part of intraciliary transport particle B. Is expressed in germ cell of ovary. Orthologous to human HSPB11 (heat shock protein family B (small) member 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E14 (RPKM 1.3), placenta adult (RPKM 1.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ift25 in Genome Data Viewer
    Location:
    4 C7; 4 50.18 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107110889..107137135)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107253593..107284497)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 1 Neighboring gene leucine rich repeat containing 42 Neighboring gene STARR-positive B cell enhancer ABC_E4642 Neighboring gene Yip1 domain family, member 1 Neighboring gene deiodinase, iodothyronine, type I Neighboring gene replication factor C (activator 1) 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Intraflagellar transporter protein (IFT27), an IFT25 binding partner, is essential for male fertility and spermiogenesis in mice. Zhang Y, et al. Dev Biol, 2017 Dec 1. PMID 28964737, Free PMC Article
    2. IFT25, an intraflagellar transporter protein dispensable for ciliogenesis in somatic cells, is essential for sperm flagella formation. Liu H, et al. Biol Reprod, 2017 May 1. PMID 28430876, Free PMC Article
    3. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Desai PB, et al. Mech Dev, 2018 Jun. PMID 29626631, Free PMC Article
    4. Single-cell transcriptome landscape of ovarian cells during primordial follicle assembly in mice. Wang JJ, et al. PLoS Biol, 2020 Dec. PMID 33351795, Free PMC Article
    5. BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia. Monis WJ, et al. J Cell Biol, 2017 Jul 3. PMID 28576874, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This work indicates that IFT25 and IFT27 are important players in the early development of the kidney and suggest that duplex kidney is part of the ciliopathy spectrum.
      Title: Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development.
    2. fFndings suggest that like IFT25, IFT27, even though not required for ciliogenesis in somatic cells, is essential for sperm flagella formation, sperm function, and male fertility in mice. IFT25 and IFT27 control sperm formation/function through many common mechanisms, but IFT25 has additional roles beyond IFT27.
      Title: Intraflagellar transporter protein (IFT27), an IFT25 binding partner, is essential for male fertility and spermiogenesis in mice.
    3. IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.
      Title: IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intraciliary anterograde transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within intraciliary transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within left/right axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cilium TAS
    Traceable Author Statement
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intraciliary transport particle B TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    intraflagellar transport protein 25 homolog
    Names
    heat shock protein beta-11
    heat shock protein family B (small), member 11
    placental protein 25 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355459.1 → NP_001342388.1  intraflagellar transport protein 25 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AA000737, AK013636, BB759869, BE863784
      Consensus CDS
      CCDS18435.1
      UniProtKB/Swiss-Prot
      Q3TZR2, Q9D6H2
      Related
      ENSMUSP00000102360.2, ENSMUST00000106749.8
      Conserved Domains (1) summary
      cl23730
      Location:19 → 121
      F5_F8_type_C; F5/8 type C domain

    2. NM_001355460.1 → NP_001342389.1  intraflagellar transport protein 25 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BB759869, BE863784
      Consensus CDS
      CCDS18435.1
      UniProtKB/Swiss-Prot
      Q3TZR2, Q9D6H2
      Related
      ENSMUSP00000118617.2, ENSMUST00000152717.8
      Conserved Domains (1) summary
      cl23730
      Location:19 → 121
      F5_F8_type_C; F5/8 type C domain

    3. NM_028394.3 → NP_082670.1  intraflagellar transport protein 25 homolog

      See identical proteins and their annotated locations for NP_082670.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AA000737, AA939607, BB759869, BY309412
      Consensus CDS
      CCDS18435.1
      UniProtKB/Swiss-Prot
      Q3TZR2, Q9D6H2
      Related
      ENSMUSP00000048810.8, ENSMUST00000046558.8
      Conserved Domains (1) summary
      cl23730
      Location:19 → 121
      F5_F8_type_C; F5/8 type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      107110889..107137135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320398.3 → XP_017175887.1  intraflagellar transport protein 25 homolog isoform X1

      UniProtKB/TrEMBL
      Q8VDG4
      Related
      ENSMUST00000156934.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6H2.2 GenPept UniProtKB/Swiss-Prot:Q9D6H2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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