Zfp622 zinc finger protein 622 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp622provided by MGI
Official Full Name: zinc finger protein 622provided by MGI
Primary source: MGI:MGI:1289282
See related: Ensembl:ENSMUSG00000052253 AllianceGenome:MGI:1289282
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZPR9; Znf622; D15Ertd806e; 1110033B05Rik
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Predicted to be located in Golgi apparatus; cytosol; and nuclear lumen. Predicted to be part of preribosome, large subunit precursor. Is expressed in several structures, including central nervous system; early conceptus; and neural retina. Orthologous to human ZNF622 (zinc finger protein 622). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 15.0), ovary adult (RPKM 12.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B1; 15 9.71 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (25984452..25998568)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (25984366..25998482)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU016070 (e-PCR)
- UniSTS:180741

D15Ertd806e (e-PCR), detects polymorphism
- UniSTS:167181

STS-AA009781 (e-PCR)
- UniSTS:56905

BB278135 (e-PCR)
- UniSTS:209074

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables preribosome binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytoplasmic 60S subunit biogenesis factor ZNF622

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144523.3 → NP_653106.1 cytoplasmic 60S subunit biogenesis factor ZNF622

See identical proteins and their annotated locations for NP_653106.1

Status: VALIDATED

Source sequence(s)

AC162303

Consensus CDS

CCDS27400.1

UniProtKB/Swiss-Prot

Q91VY9

UniProtKB/TrEMBL

Q3U343

Related

ENSMUSP00000059678.7, ENSMUST00000061875.8

Conserved Domains (4) summary

sd00020
Location:6 → 28

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12171
Location:70 → 93

zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

pfam12756
Location:253 → 352

zf-C2H2_2; C2H2 type zinc-finger (2 copies)

cl00635
Location:87 → 144

Ntn_Asparaginase_2_like; L-Asparaginase type 2-like enzymes of the NTN-hydrolase superfamily