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    Brme1 break repair meiotic recombinase recruitment factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 74666, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Brme1provided by MGI
    Official Full Name
    break repair meiotic recombinase recruitment factor 1provided by MGI
    Primary source
    MGI:MGI:1921916
    See related
    Ensembl:ENSMUSG00000008129 AllianceGenome:MGI:1921916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MRM; Mamerr; Meiok21; 4930432K21Rik
    Summary
    Involved in meiosis I and spermatogenesis. Located in chromosome. Is expressed in several structures, including 4th ventricle choroid plexus; genitourinary system; meninges; nasal epithelium; and thoracic segment skeleton. Orthologous to human BRME1 (break repair meiotic recombinase recruitment factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 23.7) and ovary adult (RPKM 2.1) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C2; 8 40.35 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84874637..84899220)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84148008..84172597)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39210 Neighboring gene DDB1 and CUL4 associated factor 15 Neighboring gene STARR-positive B cell enhancer mm9_chr8:86628640-86628941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86650788-86650941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86651237-86651346 Neighboring gene podocan-like 1 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene nanos C2HC-type zinc finger 3 Neighboring gene microRNA 181d Neighboring gene microRNA 181c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MEIOK21 regulates oocyte quantity and quality via modulating meiotic recombination. Shang Y, et al. FASEB J, 2022 Jun. PMID 35593531
    2. The novel male meiosis recombination regulator coordinates the progression of meiosis prophase I. Li M, et al. J Genet Genomics, 2020 Aug. PMID 33250349
    3. MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis. Shang Y, et al. Nucleic Acids Res, 2020 Jul 9. PMID 32463460, Free PMC Article
    4. Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination. Takemoto K, et al. Cell Rep, 2020 May 26. PMID 32460033
    5. The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells. Zhang J, et al. Nat Commun, 2020 Apr 28. PMID 32345962, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The novel male meiosis recombination regulator coordinates the progression of meiosis prophase I.
      Title: The novel male meiosis recombination regulator coordinates the progression of meiosis prophase I.
    2. A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
      Title: A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
    3. BRCA2 binds to the C-terminus of MEILB2, resulting in the formation of the BRCA2-MEILB2-BRME1 ternary complex.
      Title: The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair involved in meiotic recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    break repair meiotic recombinase recruitment factor 1
    Names
    BRCA2 and MEILB2-associating protein 1
    meiotic recombination modulator
    uncharacterized protein C19orf57 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163752.2 → NP_001157224.1  break repair meiotic recombinase recruitment factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001157224.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC159266
      Consensus CDS
      CCDS52617.1
      UniProtKB/TrEMBL
      A0A6F8PYC8
      Related
      ENSMUSP00000091067.5, ENSMUST00000093375.5
      Conserved Domains (1) summary
      pfam15710
      Location:1 → 565
      DUF4671; Domain of unknown function (DUF4671)

    2. NM_029045.3 → NP_083321.2  break repair meiotic recombinase recruitment factor 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159266
      Consensus CDS
      CCDS52616.1
      UniProtKB/Swiss-Prot
      A0A0R4J144, E9QNR8, Q6DIA7, Q9D5J2
      UniProtKB/TrEMBL
      A0A6F8PYC8
      Related
      ENSMUSP00000113651.2, ENSMUST00000118856.8
      Conserved Domains (1) summary
      pfam15710
      Location:1 → 600
      DUF4671; Domain of unknown function (DUF4671)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84874637..84899220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243821.1 → XP_030099681.1  break repair meiotic recombinase recruitment factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A6F8PYC8
      Conserved Domains (1) summary
      pfam15710
      Location:1 → 570
      DUF4671; Domain of unknown function (DUF4671)

    2. XM_006531445.4 → XP_006531508.1  break repair meiotic recombinase recruitment factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006531508.1

      UniProtKB/TrEMBL
      A0A6F8PYC8
      Conserved Domains (1) summary
      pfam15710
      Location:1 → 570
      DUF4671; Domain of unknown function (DUF4671)

    3. XM_030243822.1 → XP_030099682.1  break repair meiotic recombinase recruitment factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A6F8PYC8
      Conserved Domains (1) summary
      pfam15710
      Location:4 → 535
      DUF4671; Domain of unknown function (DUF4671)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DIA7.2 GenPept UniProtKB/Swiss-Prot:Q6DIA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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