Cep170 centrosomal protein 170 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cep170provided by MGI
Official Full Name: centrosomal protein 170provided by MGI
Primary source: MGI:MGI:1918348
See related: Ensembl:ENSMUSG00000057335 AllianceGenome:MGI:1918348
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933426L22Rik; A330004A13Rik
Summary: Located in centriole. Orthologous to human CEP170 (centrosomal protein 170). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 23.9), whole brain E14.5 (RPKM 21.2) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H4; 1 82.6 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (176556638..176641545, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (176729072..176813979, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis
Title: WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis.
Study in mutant mice and human cerebral organoids showed that WDR62 deletion resulted in a reduction in the size of mouse brains and organoids due to the disruption of neural progenitor cells. WDR62 interacts with and promotes CEP170 localization to the basal body of primary cilium, where CEP170 recruits KIF2A to disassemble cilium.
Title: Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors.
Cep170 interacts with Polo-like kinase 1 in mature centrioles [Cep170]
Title: The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF396392 (e-PCR)
- UniSTS:245764

px-38e3 (e-PCR)
- UniSTS:257695

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
part_of centriolar subdistal appendage	ISO Inferred from Sequence Orthology more info
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	ISO Inferred from Sequence Orthology more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: centrosomal protein of 170 kDa

Names: KARP-1-binding protein; centrosomal protein 170kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099637.2 → NP_001093107.2 centrosomal protein of 170 kDa isoform 1

See identical proteins and their annotated locations for NP_001093107.2

Status: VALIDATED

Source sequence(s)

AC113311, AC144905

Consensus CDS

CCDS48461.1

UniProtKB/TrEMBL

H7BX26

Related

ENSMUSP00000059562.7, ENSMUST00000057037.13

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:802 → 1496

CEP170_C; CEP170 C-terminus
NM_001368872.1 → NP_001355801.1 centrosomal protein of 170 kDa isoform 2

Status: VALIDATED

Source sequence(s)

AC113311, AC144905

Conserved Domains (2) summary

pfam15308
Location:655 → 1331

CEP170_C; CEP170 C-terminus

pfam00498
Location:23 → 89

FHA; FHA domain
NM_001368873.1 → NP_001355802.1 centrosomal protein of 170 kDa isoform 3

Status: VALIDATED

Source sequence(s)

AC113311

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:704 → 1408

CEP170_C; CEP170 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

176556638..176641545 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152447.1 → XP_036008340.1 centrosomal protein of 170 kDa isoform X15

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:667 → 1309

CEP170_C; CEP170 C-terminus
XM_036152446.1 → XP_036008339.1 centrosomal protein of 170 kDa isoform X14

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:667 → 1319

CEP170_C; CEP170 C-terminus
XM_017321736.3 → XP_017177225.1 centrosomal protein of 170 kDa isoform X13

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:654 → 1348

CEP170_C; CEP170 C-terminus
XM_006496947.4 → XP_006497010.1 centrosomal protein of 170 kDa isoform X11

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:704 → 1372

CEP170_C; CEP170 C-terminus
XM_006496945.5 → XP_006497008.1 centrosomal protein of 170 kDa isoform X10

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:704 → 1398

CEP170_C; CEP170 C-terminus
XM_036152443.1 → XP_036008336.1 centrosomal protein of 170 kDa isoform X7

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:765 → 1443

CEP170_C; CEP170 C-terminus
XM_030255572.1 → XP_030111432.1 centrosomal protein of 170 kDa isoform X8

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:802 → 1443

CEP170_C; CEP170 C-terminus
XM_030255571.1 → XP_030111431.1 centrosomal protein of 170 kDa isoform X5

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:802 → 1460

CEP170_C; CEP170 C-terminus
XM_030255570.1 → XP_030111430.1 centrosomal protein of 170 kDa isoform X4

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:802 → 1470

CEP170_C; CEP170 C-terminus
XM_030255569.1 → XP_030111429.1 centrosomal protein of 170 kDa isoform X3

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:802 → 1479

CEP170_C; CEP170 C-terminus
XM_006496939.5 → XP_006497002.1 centrosomal protein of 170 kDa isoform X2

See identical proteins and their annotated locations for XP_006497002.1

UniProtKB/TrEMBL

H7BX26

Related

ENSMUSP00000141769.2, ENSMUST00000195717.6

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:802 → 1496

CEP170_C; CEP170 C-terminus
XM_006496937.4 → XP_006497000.1 centrosomal protein of 170 kDa isoform X1

See identical proteins and their annotated locations for XP_006497000.1

UniProtKB/Swiss-Prot

Q6A065, Q7TQD9, Q8BJW2, Q9D3Z0

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:802 → 1506

CEP170_C; CEP170 C-terminus
XM_006496940.5 → XP_006497003.1 centrosomal protein of 170 kDa isoform X2

See identical proteins and their annotated locations for XP_006497003.1

UniProtKB/TrEMBL

H7BX26

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:802 → 1496

CEP170_C; CEP170 C-terminus
XM_006496948.5 → XP_006497011.1 centrosomal protein of 170 kDa isoform X12

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:654 → 1358

CEP170_C; CEP170 C-terminus
XM_006496944.5 → XP_006497007.1 centrosomal protein of 170 kDa isoform X9

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:704 → 1408

CEP170_C; CEP170 C-terminus
XM_006496943.5 → XP_006497006.1 centrosomal protein of 170 kDa isoform X6

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:752 → 1456

CEP170_C; CEP170 C-terminus
XM_030255566.2 → XP_030111426.1 centrosomal protein of 170 kDa isoform X1

UniProtKB/Swiss-Prot

Q6A065, Q7TQD9, Q8BJW2, Q9D3Z0

Related

ENSMUSP00000141793.2, ENSMUST00000194727.6

Conserved Domains (2) summary

cd00060
Location:5 → 98

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam15308
Location:802 → 1506

CEP170_C; CEP170 C-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001024722.1: Suppressed sequence

Description

NM_001024722.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.