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    Ankrd33b ankyrin repeat domain 33B [ Mus musculus (house mouse) ]

    Gene ID: 67434, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ankrd33bprovided by MGI
    Official Full Name
    ankyrin repeat domain 33Bprovided by MGI
    Primary source
    MGI:MGI:1917904
    See related
    Ensembl:ENSMUSG00000022237 AllianceGenome:MGI:1917904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610012A05Rik; 3021401C12Rik; 5730557B15Rik
    Summary
    Predicted to enable DNA binding activity. Is expressed in brain; embryo endoderm; notochord; and retina. Orthologous to human ANKRD33B (ankyrin repeat domain 33B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 10.0), cortex adult (RPKM 6.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 B2; 15 12.76 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (31278328..31370446, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (31291479..31367802, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene death-associated protein Neighboring gene predicted gene, 41285 Neighboring gene STARR-positive B cell enhancer ABC_E3134 Neighboring gene family with sequence similarity 136, member B, pseudogene Neighboring gene STARR-seq mESC enhancer starr_38282 Neighboring gene STARR-positive B cell enhancer ABC_E9415 Neighboring gene STARR-positive B cell enhancer ABC_E5472 Neighboring gene STARR-seq mESC enhancer starr_38287 Neighboring gene predicted gene, 41286 Neighboring gene STARR-seq mESC enhancer starr_38289 Neighboring gene ropporin 1-like Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Yoshida S, et al. Hum Mol Genet, 2004 Jul 15. PMID 15163632
    2. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 33B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164441.1 → NP_001157913.1  ankyrin repeat domain-containing protein 33B isoform 3

      See identical proteins and their annotated locations for NP_001157913.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC115735, AC123917
      Consensus CDS
      CCDS49589.1
      UniProtKB/Swiss-Prot
      Q3U0L2, Q8BJA8, Q9CYB2, Q9CZ88, Q9DCQ8
      Related
      ENSMUSP00000118984.2, ENSMUST00000123325.9
      Conserved Domains (4) summary
      cd00204
      Location:112 → 239
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:121 → 216
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:83 → 136
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:116 → 148
      ANK; ANK repeat [structural motif]

    2. NM_001357922.1 → NP_001344851.1  ankyrin repeat domain-containing protein 33B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 4 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC115735, AC123917
      Conserved Domains (1) summary
      cd00204
      Location:1 → 49
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

    3. NM_001357923.1 → NP_001344852.1  ankyrin repeat domain-containing protein 33B isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 5, which is shorter than isoform 1.
      Source sequence(s)
      AC115735, AC123917
      Conserved Domains (2) summary
      cd00204
      Location:24 → 101
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:47 → 78
      ANK; ANK repeat [structural motif]

    4. NM_026153.3 → NP_080429.1  ankyrin repeat domain-containing protein 33B isoform 1

      See identical proteins and their annotated locations for NP_080429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 3. The resulting isoform (1) has a shorter and distinct C-terminus, compared to isoform 3.
      Source sequence(s)
      AC123917, AK012871, BC100327
      Consensus CDS
      CCDS27409.1
      UniProtKB/TrEMBL
      H7BX04
      Related
      ENSMUSP00000076209.5, ENSMUST00000076942.5

    5. NM_027496.3 → NP_081772.1  ankyrin repeat domain-containing protein 33B isoform 2

      See identical proteins and their annotated locations for NP_081772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. The resulting isoform (2) lacks an internal segment near the N-terminus, compared to isoform 3.
      Source sequence(s)
      AC123917, AK017844, BC100327
      Consensus CDS
      CCDS27408.1
      UniProtKB/Swiss-Prot
      Q3U0L2
      Related
      ENSMUSP00000106040.3, ENSMUST00000110410.10
      Conserved Domains (3) summary
      cd00204
      Location:109 → 230
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:112 → 207
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:107 → 139
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      31278328..31370446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159549.1 → XP_036015442.1  ankyrin repeat domain-containing protein 33B isoform X1

      Conserved Domains (3) summary
      sd00045
      Location:85 → 114
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:84 → 136
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:121 → 209
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006520155.5 → XP_006520218.1  ankyrin repeat domain-containing protein 33B isoform X2

      Conserved Domains (2) summary
      sd00045
      Location:85 → 114
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:85 → 160
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_004938864.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U0L2.1 GenPept UniProtKB/Swiss-Prot:Q3U0L2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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