Eml6 echinoderm microtubule associated protein like 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eml6provided by MGI
Official Full Name: echinoderm microtubule associated protein like 6provided by MGI
Primary source: MGI:MGI:2442895
See related: Ensembl:ENSMUSG00000044072 AllianceGenome:MGI:2442895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EMAP-6; 2900083P10Rik; C230094A16Rik
Summary: Predicted to enable microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Is expressed in nervous system and sensory organ. Orthologous to human EML6 (EMAP like 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 7.3), CNS E11.5 (RPKM 7.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A3.3; 11 16.83 cM

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (29693044..29976044, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (29743044..30026045, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA960376 (e-PCR)
- UniSTS:160077

AB049853 (e-PCR)
- UniSTS:480168

RH125740 (e-PCR)
- UniSTS:162496

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: echinoderm microtubule-associated protein-like 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146016.2 → NP_666128.2 echinoderm microtubule-associated protein-like 6

See identical proteins and their annotated locations for NP_666128.2

Status: VALIDATED

Source sequence(s)

AK049034, AK081418, BB395696, BB633761, BC024726, BY740982

UniProtKB/Swiss-Prot

Q5SQM0, Q8C4R3, Q8C7L3, Q8R1E3

Related

ENSMUSP00000051080.6, ENSMUST00000058902.6

Conserved Domains (4) summary

COG2319
Location:48 → 464

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:2 → 48

HELP; HELP motif

sd00039
Location:64 → 104

7WD40; WD40 repeat [structural motif]

cl02567
Location:57 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

29693044..29976044 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156653.1 → XP_036012546.1 echinoderm microtubule-associated protein-like 6 isoform X1

Conserved Domains (5) summary

smart00320
Location:1948 → 1987

WD40; WD40 repeats

COG2319
Location:1433 → 1862

WD40; WD40 repeat [General function prediction only]

sd00039
Location:64 → 104

7WD40; WD40 repeat [structural motif]

pfam03451
Location:2 → 48

HELP; HELP motif

cl29593
Location:57 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036156654.1 → XP_036012547.1 echinoderm microtubule-associated protein-like 6 isoform X6

Conserved Domains (5) summary

smart00320
Location:1923 → 1962

WD40; WD40 repeats

COG2319
Location:1408 → 1837

WD40; WD40 repeat [General function prediction only]

sd00039
Location:64 → 104

7WD40; WD40 repeat [structural motif]

pfam03451
Location:2 → 48

HELP; HELP motif

cl29593
Location:57 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017314513.3 → XP_017170002.1 echinoderm microtubule-associated protein-like 6 isoform X2

Conserved Domains (5) summary

smart00320
Location:1947 → 1986

WD40; WD40 repeats

COG2319
Location:1432 → 1861

WD40; WD40 repeat [General function prediction only]

sd00039
Location:64 → 104

7WD40; WD40 repeat [structural motif]

pfam03451
Location:2 → 48

HELP; HELP motif

cl29593
Location:57 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017314516.3 → XP_017170005.1 echinoderm microtubule-associated protein-like 6 isoform X5

Conserved Domains (5) summary

smart00320
Location:1924 → 1963

WD40; WD40 repeats

COG2319
Location:1409 → 1838

WD40; WD40 repeat [General function prediction only]

sd00039
Location:64 → 104

7WD40; WD40 repeat [structural motif]

pfam03451
Location:2 → 48

HELP; HELP motif

cl29593
Location:57 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017314515.3 → XP_017170004.1 echinoderm microtubule-associated protein-like 6 isoform X4

Conserved Domains (5) summary

smart00320
Location:1940 → 1979

WD40; WD40 repeats

COG2319
Location:1425 → 1854

WD40; WD40 repeat [General function prediction only]

sd00039
Location:64 → 104

7WD40; WD40 repeat [structural motif]

pfam03451
Location:2 → 48

HELP; HELP motif

cl29593
Location:57 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017314514.3 → XP_017170003.1 echinoderm microtubule-associated protein-like 6 isoform X3

Conserved Domains (5) summary

smart00320
Location:1943 → 1982

WD40; WD40 repeats

COG2319
Location:1428 → 1857

WD40; WD40 repeat [General function prediction only]

sd00039
Location:64 → 104

7WD40; WD40 repeat [structural motif]

pfam03451
Location:2 → 48

HELP; HELP motif

cl29593
Location:57 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006514694.5 → XP_006514757.1 echinoderm microtubule-associated protein-like 6 isoform X1

Conserved Domains (5) summary

smart00320
Location:1948 → 1987

WD40; WD40 repeats

COG2319
Location:1433 → 1862

WD40; WD40 repeat [General function prediction only]

sd00039
Location:64 → 104

7WD40; WD40 repeat [structural motif]

pfam03451
Location:2 → 48

HELP; HELP motif

cl29593
Location:57 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006514695.4 → XP_006514758.1 echinoderm microtubule-associated protein-like 6 isoform X7

Conserved Domains (5) summary

smart00320
Location:1155 → 1194

WD40; WD40 repeats

COG2319
Location:640 → 1069

WD40; WD40 repeat [General function prediction only]

sd00039
Location:232 → 272

7WD40; WD40 repeat [structural motif]

pfam03451
Location:600 → 640

HELP; HELP motif

cl29593
Location:224 → 497

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...