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    Mindy1 MINDY lysine 48 deubiquitinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 75007, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mindy1provided by MGI
    Official Full Name
    MINDY lysine 48 deubiquitinase 1provided by MGI
    Primary source
    MGI:MGI:1922257
    See related
    Ensembl:ENSMUSG00000038712 AllianceGenome:MGI:1922257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ni; cI-40; Fam63a; mKIAA1390; 1810005H09Rik; 4930504E06Rik
    Summary
    Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity; Lys48-specific deubiquitinase activity; and cysteine-type carboxypeptidase activity. Predicted to be involved in protein K48-linked deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be located in nuclear body. Orthologous to human MINDY1 (MINDY lysine 48 deubiquitinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 42.0), ovary adult (RPKM 32.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mindy1 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95189237..95203477)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95281926..95296166)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene annexin A9 Neighboring gene STARR-positive B cell enhancer ABC_E9560 Neighboring gene predicted gene, 53243 Neighboring gene ceramide synthase 2 Neighboring gene SET domain, bifurcated 1 Neighboring gene STARR-seq mESC enhancer starr_08380 Neighboring gene predicted gene, 37500

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MINDY1 Is a Downstream Target of the Polyamines and Promotes Embryonic Stem Cell Self-Renewal. James C, et al. Stem Cells, 2018 Aug. PMID 29644784
    2. NF-E2-mediated enhancement of megakaryocytic differentiation and platelet production in vitro and in vivo. Fock EL, et al. Exp Hematol, 2008 Jan. PMID 17923245
    3. Genetic analysis of the diabetes-prone C57BLKS/J mouse strain reveals genetic contribution from multiple strains. Mao HZ, et al. Biochim Biophys Acta, 2006 Apr. PMID 16481151
    4. Identification of cAMP analogue inducible genes in RAW264 macrophages. Takahashi Y, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 11004510
    5. ¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models. Probert F, et al. J Proteome Res, 2015 May 1. PMID 25849460

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K48-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K48-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase MINDY-1
    Names
    NF-E2 inducible protein
    deubiquitinating enzyme MINDY-1
    family with sequence similarity 63, member A
    protein FAM63A
    NP_598619.2
    NP_955769.1
    XP_006502282.1
    XP_011238563.1
    XP_030108719.1
    XP_030108720.1
    XP_036019260.1
    XP_036019261.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133858.4 → NP_598619.2  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 2

      See identical proteins and their annotated locations for NP_598619.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AK036838, BC094388, BQ571591
      Consensus CDS
      CCDS17611.1
      UniProtKB/Swiss-Prot
      Q76LS9
      Related
      ENSMUSP00000043910.8, ENSMUST00000039537.14
      Conserved Domains (1) summary
      pfam04424
      Location:144 → 261
      DUF544; Protein of unknown function (DUF544)

    2. NM_199475.1 → NP_955769.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1

      See identical proteins and their annotated locations for NP_955769.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC094388, BC132301, BQ571591
      Consensus CDS
      CCDS57233.1
      UniProtKB/Swiss-Prot
      Q3TEF4, Q52KE4, Q566I9, Q6PES4, Q76LS9, Q80V14, Q8CB41, Q8CHR2
      UniProtKB/TrEMBL
      B7ZMR0
      Related
      ENSMUSP00000102805.3, ENSMUST00000107187.9
      Conserved Domains (1) summary
      pfam04424
      Location:144 → 261
      MINDY_DUB; MINDY deubiquitinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95189237..95203477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502219.4 → XP_006502282.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X1

      See identical proteins and their annotated locations for XP_006502282.1

      UniProtKB/Swiss-Prot
      Q3TEF4, Q52KE4, Q566I9, Q6PES4, Q76LS9, Q80V14, Q8CB41, Q8CHR2
      UniProtKB/TrEMBL
      B7ZMR0
      Conserved Domains (1) summary
      pfam04424
      Location:144 → 261
      MINDY_DUB; MINDY deubiquitinase

    2. XM_036163368.1 → XP_036019261.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X2

      Conserved Domains (1) summary
      pfam04424
      Location:1 → 64
      MINDY_DUB; MINDY deubiquitinase

    3. XM_036163367.1 → XP_036019260.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TEF4, Q52KE4, Q566I9, Q6PES4, Q76LS9, Q80V14, Q8CB41, Q8CHR2
      UniProtKB/TrEMBL
      B7ZMR0
      Conserved Domains (1) summary
      pfam04424
      Location:144 → 261
      MINDY_DUB; MINDY deubiquitinase

    4. XM_030252859.2 → XP_030108719.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X2

      Conserved Domains (1) summary
      pfam04424
      Location:1 → 64
      MINDY_DUB; MINDY deubiquitinase

    5. XM_011240261.3 → XP_011238563.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X2

      See identical proteins and their annotated locations for XP_011238563.1

      Conserved Domains (1) summary
      pfam04424
      Location:1 → 64
      MINDY_DUB; MINDY deubiquitinase

    6. XM_030252860.1 → XP_030108720.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X3

      Conserved Domains (1) summary
      pfam04424
      Location:1 → 64
      MINDY_DUB; MINDY deubiquitinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76LS9.1 GenPept UniProtKB/Swiss-Prot:Q76LS9

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