U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ska3 spindle and kinetochore associated complex subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 219114, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ska3provided by MGI
    Official Full Name
    spindle and kinetochore associated complex subunit 3provided by MGI
    Primary source
    MGI:MGI:3041235
    See related
    Ensembl:ENSMUSG00000021965 AllianceGenome:MGI:3041235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F630043A04Rik
    Summary
    Predicted to be involved in chromosome segregation; mitotic cell cycle; and regulation of microtubule polymerization or depolymerization. Predicted to act upstream of or within cell division. Predicted to be located in cytosol; kinetochore; and microtubule cytoskeleton. Predicted to be part of outer kinetochore. Predicted to be active in spindle microtubule. Is expressed in brain; heart ventricle; lung; and vertebral axis musculature. Orthologous to human SKA3 (spindle and kinetochore associated complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.5), liver E14 (RPKM 5.2) and 20 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ska3 in Genome Data Viewer
    Location:
    14 C3; 14 30.51 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (58044016..58063748, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57806558..57826291, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene large tumor suppressor 2 Neighboring gene predicted gene, 52140 Neighboring gene STARR-seq mESC enhancer starr_36815 Neighboring gene microRNA 3077 Neighboring gene Sin3-associated polypeptide 18 Neighboring gene STARR-positive B cell enhancer ABC_E10829 Neighboring gene mitochondrial ribosomal protein L57 Neighboring gene predicted gene, 22738 Neighboring gene zinc finger, DHHC domain containing 20 Neighboring gene STARR-seq mESC enhancer starr_36817 Neighboring gene STARR-seq mESC enhancer starr_36818 Neighboring gene STARR-positive B cell enhancer ABC_E7320

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. SKA3, negatively regulated by miR-128-3p, promotes the progression of non-small-cell lung cancer. Xie L, et al. Per Med, 2022 May. PMID 34533066
    2. Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division. Theis M, et al. EMBO J, 2009 May 20. PMID 19387489, Free PMC Article
    3. Localization and function of the Ska complex during mouse oocyte meiotic maturation. Zhang QH, et al. Cell Cycle, 2012 Mar 1. PMID 22336914
    4. A blueprint for kinetochores - new insights into the molecular mechanics of cell division. Lampert F, et al. Nat Rev Mol Cell Biol, 2011 Jun 2. PMID 21633384
    5. Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis. Gao W, et al. Cell Death Dis, 2020 Oct 26. PMID 33106477, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    spindle and kinetochore-associated protein 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418937.1 → NP_001405866.1  spindle and kinetochore-associated protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119813

    2. NM_001418938.1 → NP_001405867.1  spindle and kinetochore-associated protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119813

    3. NM_001418939.1 → NP_001405868.1  spindle and kinetochore-associated protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119813

    4. NM_198605.4 → NP_941007.1  spindle and kinetochore-associated protein 3 isoform 1

      See identical proteins and their annotated locations for NP_941007.1

      Status: VALIDATED

      Source sequence(s)
      AC119813
      Consensus CDS
      CCDS27160.1
      UniProtKB/Swiss-Prot
      Q149T5, Q149T6, Q8C263
      Related
      ENSMUSP00000022536.3, ENSMUST00000022536.3
      Conserved Domains (1) summary
      cd12957
      Location:3 → 101
      SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain

    RNA

    1. NR_184859.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC119813

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      58044016..58063748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004938385.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C263.1 GenPept UniProtKB/Swiss-Prot:Q8C263

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous