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    Tatdn2 TatD DNase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 381801, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tatdn2provided by MGI
    Official Full Name
    TatD DNase domain containing 2provided by MGI
    Primary source
    MGI:MGI:3576210
    See related
    Ensembl:ENSMUSG00000056952 AllianceGenome:MGI:3576210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0218
    Summary
    Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human TATDN2 (TatD DNase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.5), spleen adult (RPKM 11.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 E3; 6 52.83 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113674090..113688030)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113697050..113711082)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2798 Neighboring gene von Hippel-Lindau tumor suppressor Neighboring gene interleukin-1 receptor-associated kinase 2 Neighboring gene STARR-seq mESC enhancer starr_17046 Neighboring gene STARR-positive B cell enhancer ABC_E6467 Neighboring gene STARR-positive B cell enhancer ABC_E6468 Neighboring gene STARR-positive B cell enhancer ABC_E3671 Neighboring gene STARR-positive B cell enhancer ABC_E9672 Neighboring gene STARR-positive B cell enhancer ABC_E1707 Neighboring gene STARR-seq mESC enhancer starr_17051 Neighboring gene STARR-positive B cell enhancer ABC_E6469 Neighboring gene microRNA 7042 Neighboring gene ghrelin Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory. Hardy MP, et al. J Biol Chem, 2004 Jun 25. PMID 15082713
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0218

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    putative deoxyribonuclease TATDN2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033463.5 → NP_001028635.2  putative deoxyribonuclease TATDN2 isoform 2

      See identical proteins and their annotated locations for NP_001028635.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1
      Source sequence(s)
      AC117596, AC153987
      Consensus CDS
      CCDS20431.1
      UniProtKB/TrEMBL
      F8VQE6, Q3U179
      Related
      ENSMUSP00000086412.5, ENSMUST00000089018.11
      Conserved Domains (2) summary
      COG1099
      Location:456 → 722
      COG1099; Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only]
      pfam01026
      Location:457 → 721
      TatD_DNase; TatD related DNase

    2. NM_001347356.2 → NP_001334285.1  putative deoxyribonuclease TATDN2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC117596, AC153987
      Consensus CDS
      CCDS85124.1
      UniProtKB/TrEMBL
      B7ZNL9, Q571H2
      Related
      ENSMUSP00000145308.2, ENSMUST00000204753.3

    3. NM_001411779.1 → NP_001398708.1  putative deoxyribonuclease TATDN2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117596, AC153987

    4. NM_001411780.1 → NP_001398709.1  putative deoxyribonuclease TATDN2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117596, AC153987

    RNA

    1. NR_177929.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117596, AC153987

    2. NR_177930.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117596, AC153987

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      113674090..113688030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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