Slco2b1 solute carrier organic anion transporter family, member 2b1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slco2b1provided by MGI
Official Full Name: solute carrier organic anion transporter family, member 2b1provided by MGI
Primary source: MGI:MGI:1351872
See related: Ensembl:ENSMUSG00000030737 AllianceGenome:MGI:1351872
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OATP-B; OATP2B1; Slc21a9
Summary: Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport and transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in apical plasma membrane and basal plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in blood vessel; brain meninges; and embryo. Orthologous to human SLCO2B1 (solute carrier organic anion transporter family member 2B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 40.1), mammary gland adult (RPKM 19.5) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 54.11 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (99307011..99360547, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (99657804..99711340, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability.
Title: Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability.
Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions.
Title: Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions.
depression disorder (DD) was the adverse factors for the overall occurrence risk of hepatocellular carcinoma (HCC). Mechanistically, be the downregulation of Oatp2a1 and Oatp2b1 in liver tissue induced by DD might be involved
Title: Risk of Developing Hepatocellular Carcinoma following Depressive Disorder Based on the Expression Level of Oatp2a1 and Oatp2b1.
OATP2B1 downregulation in mouse brain can suppress tolerance via blocking morphine and M6G brain transport. These findings might help to improve the pharmacological effects of morphine
Title: siRNA capsulated brain-targeted nanoparticles specifically knock down OATP2B1 in mice: a mechanism for acute morphine tolerance suppression.
OATP2B1 contributes to the uptake of SN-38 by intestinal tissues, triggering gastrointestinal toxicity.
Title: Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Slco2b1 (e-PCR), detects polymorphism
- UniSTS:547364

AI060904 (e-PCR)
- UniSTS:179610

AI852653 (e-PCR)
- UniSTS:179611

D7Mit39 (e-PCR), detects polymorphism
- UniSTS:116731

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium-independent organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in sodium-independent icosanoid transport	ISO Inferred from Sequence Orthology more info
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 2B1

Names: organic anion transporting polypeptide 2B1; solute carrier family 21 (organic anion transporter), member 9; solute carrier family 21 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252530.2 → NP_001239459.1 solute carrier organic anion transporter family member 2B1 isoform 1

See identical proteins and their annotated locations for NP_001239459.1

Status: VALIDATED

Source sequence(s)

AC111086

Consensus CDS

CCDS57567.1

UniProtKB/TrEMBL

Q3TQJ3, Q3V1K7

Related

ENSMUSP00000102703.2, ENSMUST00000107088.8

Conserved Domains (3) summary

cd06174
Location:58 → 301

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:484 → 541

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:52 → 646

OATP; Organic Anion Transporter Polypeptide (OATP) family
NM_001252531.2 → NP_001239460.1 solute carrier organic anion transporter family member 2B1 isoform 2

See identical proteins and their annotated locations for NP_001239460.1

Status: VALIDATED

Source sequence(s)

AC111086

Consensus CDS

CCDS21485.1

UniProtKB/Swiss-Prot

Q8BLV8, Q8BXB6

UniProtKB/TrEMBL

Q4VA99

Related

ENSMUSP00000102701.3, ENSMUST00000107086.9

Conserved Domains (1) summary

cl28910
Location:40 → 577

MFS; Major Facilitator Superfamily
NM_175316.3 → NP_780525.1 solute carrier organic anion transporter family member 2B1 isoform 2

See identical proteins and their annotated locations for NP_780525.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a different exon for its 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1. Variants 2 and 3 encode the same protein.

Source sequence(s)

AK048120

Consensus CDS

CCDS21485.1

UniProtKB/Swiss-Prot

Q8BLV8, Q8BXB6

UniProtKB/TrEMBL

Q4VA99

Related

ENSMUSP00000032985.5, ENSMUST00000032985.11

Conserved Domains (1) summary

cl28910
Location:40 → 577

MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

99307011..99360547 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241641.4 → XP_011239943.1 solute carrier organic anion transporter family member 2B1 isoform X2

See identical proteins and their annotated locations for XP_011239943.1

UniProtKB/Swiss-Prot

Q8BLV8, Q8BXB6

UniProtKB/TrEMBL

Q4VA99

Conserved Domains (1) summary

cl28910
Location:40 → 577

MFS; Major Facilitator Superfamily
XM_011241640.4 → XP_011239942.1 solute carrier organic anion transporter family member 2B1 isoform X2

See identical proteins and their annotated locations for XP_011239942.1

UniProtKB/Swiss-Prot

Q8BLV8, Q8BXB6

UniProtKB/TrEMBL

Q4VA99

Conserved Domains (1) summary

cl28910
Location:40 → 577

MFS; Major Facilitator Superfamily
XM_011241638.4 → XP_011239940.1 solute carrier organic anion transporter family member 2B1 isoform X1

See identical proteins and their annotated locations for XP_011239940.1

UniProtKB/TrEMBL

Q4VA99

Conserved Domains (1) summary

cl28910
Location:54 → 591

MFS; Major Facilitator Superfamily
XM_011241639.1 → XP_011239941.1 solute carrier organic anion transporter family member 2B1 isoform X1

See identical proteins and their annotated locations for XP_011239941.1

UniProtKB/TrEMBL

Q4VA99

Conserved Domains (1) summary

cl28910
Location:54 → 591

MFS; Major Facilitator Superfamily
XM_011241637.4 → XP_011239939.1 solute carrier organic anion transporter family member 2B1 isoform X1

See identical proteins and their annotated locations for XP_011239939.1

UniProtKB/TrEMBL

Q4VA99

Conserved Domains (1) summary

cl28910
Location:54 → 591

MFS; Major Facilitator Superfamily