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    Hsd17b8 hydroxysteroid 17-beta dehydrogenase 8 [ Mus musculus (house mouse) ]

    Gene ID: 14979, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hsd17b8provided by MGI
    Official Full Name
    hydroxysteroid 17-beta dehydrogenase 8provided by MGI
    Primary source
    MGI:MGI:95911
    See related
    Ensembl:ENSMUSG00000073422 AllianceGenome:MGI:95911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ke6; Ke-6; Ring2; H-2Ke6; H2-Ke6; D17H6S112E
    Summary
    Enables estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Acts upstream of or within androgen metabolic process and estrogen metabolic process. Located in mitochondrial envelope and plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 155.4), ovary adult (RPKM 72.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 17.98 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34245007..34247029, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34026033..34028055, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 1 Neighboring gene microRNA 219a-1 Neighboring gene microRNA 219c Neighboring gene STARR-positive B cell enhancer ABC_E5594 Neighboring gene solute carrier family 39 (zinc transporter), member 7 Neighboring gene STARR-positive B cell enhancer ABC_E5595 Neighboring gene retinoid X receptor beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Abnormal regulation of the Ke 6 gene, a new 17beta-hydroxysteroid dehydrogenase in the cpk mouse kidney. Ramirez S, et al. Mol Cell Endocrinol, 1998 Aug 25. PMID 9806346
    2. Immature ovaries and polycystic kidneys in the congenital polycystic kidney mouse may be due to abnormal sex steroid metabolism. Woo D, et al. Mol Cell Endocrinol, 2001 May 15. PMID 11369455
    3. Arrested testis development in the cpk mouse may be the result of abnormal steroid metabolism. Aziz N, et al. Mol Cell Endocrinol, 2001 Jan 22. PMID 11165015
    4. Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues. Fomitcheva J, et al. J Biol Chem, 1998 Aug 28. PMID 9712896
    5. Downregulation of Ke 6, a novel gene encoded within the major histocompatibility complex, in murine polycystic kidney disease. Aziz N, et al. Mol Cell Biol, 1993 Mar. PMID 8441417, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107650

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables estradiol 17-beta-dehydrogenase [NAD(P)] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within androgen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in estrogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in estrogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of oxidoreductase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    (3R)-3-hydroxyacyl-CoA dehydrogenase
    Names
    17-beta-HSD 8
    17-beta-hydroxysteroid dehydrogenase 8
    3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit
    3-oxoacyl-[acyl-carrier-protein] reductase
    H2-K region expressed gene 6
    KAR alpha subunit
    estradiol 17-beta-dehydrogenase 8
    estrogen 17-oxidoreductase
    testosterone 17-beta-dehydrogenase 8
    NP_038571.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013543.2 → NP_038571.2  (3R)-3-hydroxyacyl-CoA dehydrogenase

      See identical proteins and their annotated locations for NP_038571.2

      Status: VALIDATED

      Source sequence(s)
      BC086927, CX243612
      Consensus CDS
      CCDS50071.1
      UniProtKB/Swiss-Prot
      P50171, Q5M9K0, Q60958, Q60959, Q9Z1W2
      UniProtKB/TrEMBL
      A0A068BEQ2
      Related
      ENSMUSP00000038069.8, ENSMUST00000045467.14
      Conserved Domains (2) summary
      PRK05653
      Location:12 → 259
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
      cl21454
      Location:11 → 258
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34245007..34247029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50171.2 GenPept UniProtKB/Swiss-Prot:P50171

    Gene LinkOut

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