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    Dcun1d4 defective in cullin neddylation 1 domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 100737, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dcun1d4provided by MGI
    Official Full Name
    defective in cullin neddylation 1 domain containing 4provided by MGI
    Primary source
    MGI:MGI:2140972
    See related
    Ensembl:ENSMUSG00000051674 AllianceGenome:MGI:2140972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DCNL4
    Summary
    Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in positive regulation of protein neddylation; positive regulation of ubiquitin-protein transferase activity; and protein neddylation. Predicted to be located in nucleus. Predicted to be part of ubiquitin ligase complex. Is expressed in early conceptus; genitourinary system; nervous system; and neural retina. Orthologous to human DCUN1D4 (defective in cullin neddylation 1 domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 6.2), cortex adult (RPKM 5.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 C3.3; 5 38.85 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73638353..73718137)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (73481010..73560794)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cell wall biogenesis 43 C-terminal homolog Neighboring gene STARR-seq mESC enhancer starr_13387 Neighboring gene STARR-positive B cell enhancer ABC_E153 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene leucine rich repeat containing 66 Neighboring gene sarcoglycan, beta (dystrophin-associated glycoprotein)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    2. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117952

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DCN1-like protein 4
    Names
    DCN1, defective in cullin neddylation 1, domain containing 4
    DCUN1 domain-containing protein 4
    defective in cullin neddylation protein 1-like protein 4
    squamous cell carcinoma-related oncogene 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190733.2 → NP_001177662.1  DCN1-like protein 4 isoform C

      See identical proteins and their annotated locations for NP_001177662.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C) differs in the 5' UTR, lacks a portion of the 5' coding region and an in-frame exon in the 3' coding region, and initiates translation at an alternate start codon, compared to variant A. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform A.
      Source sequence(s)
      AC134551, AC140429
      Consensus CDS
      CCDS57350.1
      UniProtKB/TrEMBL
      B7ZMU0
      Related
      ENSMUSP00000109187.2, ENSMUST00000113558.8
      Conserved Domains (1) summary
      pfam03556
      Location:175 → 251
      Cullin_binding; Cullin binding

    2. NM_001190734.2 → NP_001177663.1  DCN1-like protein 4 isoform A

      See identical proteins and their annotated locations for NP_001177663.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) encodes the longest isoform (A).
      Source sequence(s)
      AC134551, AC140429
      Consensus CDS
      CCDS57349.1
      UniProtKB/TrEMBL
      Q8C5X2
      Related
      ENSMUSP00000084427.6, ENSMUST00000087181.12
      Conserved Domains (1) summary
      pfam03556
      Location:189 → 300
      Cullin_binding; Cullin binding

    3. NM_001425798.1 → NP_001412727.1  DCN1-like protein 4 isoform D

      Status: VALIDATED

      Source sequence(s)
      AC134551, AC140429

    4. NM_001425799.1 → NP_001412728.1  DCN1-like protein 4 isoform E

      Status: VALIDATED

      Source sequence(s)
      AC134551, AC140429

    5. NM_001425800.1 → NP_001412729.1  DCN1-like protein 4 isoform E

      Status: VALIDATED

      Source sequence(s)
      AC134551, AC140429

    6. NM_178896.6 → NP_849227.1  DCN1-like protein 4 isoform B

      See identical proteins and their annotated locations for NP_849227.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant A. The encoded isoform (B) has a distinct N-terminus and is shorter than isoform A.
      Source sequence(s)
      AC134551, AC140429
      Consensus CDS
      CCDS19342.1
      UniProtKB/Swiss-Prot
      Q2YDW5, Q8CCA0
      Related
      ENSMUSP00000067616.6, ENSMUST00000063882.12
      Conserved Domains (1) summary
      pfam03556
      Location:175 → 286
      Cullin_binding; Cullin binding

    RNA

    1. NR_153313.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (D) differs in the 5' end and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC134551, AC140429

    2. NR_189590.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC134551, AC140429

    3. NR_189591.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC134551, AC140429

    4. NR_189592.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC134551, AC140429

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      73638353..73718137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503631.3 → XP_006503694.1  DCN1-like protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006503694.1

      Conserved Domains (1) summary
      pfam03556
      Location:115 → 225
      Cullin_binding; Cullin binding

    2. XM_030254025.1 → XP_030109885.1  DCN1-like protein 4 isoform X2

      Conserved Domains (1) summary
      pfam03556
      Location:115 → 225
      Cullin_binding; Cullin binding

    3. XM_006503636.4 → XP_006503699.1  DCN1-like protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006503699.1

      Conserved Domains (1) summary
      pfam03556
      Location:115 → 225
      Cullin_binding; Cullin binding

    4. XM_017320580.3 → XP_017176069.1  DCN1-like protein 4 isoform X3

      Conserved Domains (1) summary
      pfam03556
      Location:94 → 204
      Cullin_binding; Cullin binding

    5. XM_036164695.1 → XP_036020588.1  DCN1-like protein 4 isoform X2

      Conserved Domains (1) summary
      pfam03556
      Location:115 → 225
      Cullin_binding; Cullin binding

    6. XM_006503628.5 → XP_006503691.1  DCN1-like protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006503691.1

      Conserved Domains (1) summary
      pfam03556
      Location:115 → 225
      Cullin_binding; Cullin binding

    7. XM_006503630.5 → XP_006503693.1  DCN1-like protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006503693.1

      Conserved Domains (1) summary
      pfam03556
      Location:115 → 225
      Cullin_binding; Cullin binding

    8. XM_036164694.1 → XP_036020587.1  DCN1-like protein 4 isoform X2

      Conserved Domains (1) summary
      pfam03556
      Location:115 → 225
      Cullin_binding; Cullin binding

    9. XM_006503637.5 → XP_006503700.1  DCN1-like protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006503700.1

      Conserved Domains (1) summary
      pfam03556
      Location:115 → 225
      Cullin_binding; Cullin binding

    RNA

    1. XR_376792.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CCA0.1 GenPept UniProtKB/Swiss-Prot:Q8CCA0

    Gene LinkOut

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