Taf1 TATA-box binding protein associated factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taf1provided by MGI
Official Full Name: TATA-box binding protein associated factor 1provided by MGI
Primary source: MGI:MGI:1336878
See related: Ensembl:ENSMUSG00000031314 AllianceGenome:MGI:1336878
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ccg1; KAT4; p250; Ccg-1; Taf2a; N-TAF1; TAFII250; B430306D02Rik
Summary: Enables DNA binding activity; histone acetyltransferase activity; and promoter-specific chromatin binding activity. Involved in histone acetylation. Located in pronucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Orthologous to several human genes including TAF1 (TATA-box binding protein associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 8.6), CNS E14 (RPKM 5.7) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 44.29 cM

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (100576335..100644635)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (101527572..101601789)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.
Title: Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.
these result suggests that the N-Taf1 gene has an important role in non-dividing neuronal cell rather than in cell division and proliferation during neurogenesis.
Title: Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.
Data show that Taf1 is decreased at the osteogenic initiation stage in the maxilla of Tgfbr2 mutant mice.
Title: Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.
Appears in pronuclei 6 h post-fertilization and reached a relatively high level before zygotic genome activation.
Title: Regulated expression of TAF1 in 1-cell mouse embryos.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-62g3 (e-PCR)
- UniSTS:258063

TAF2A2-1 (e-PCR)
- UniSTS:257056

TAF2A2-3 (e-PCR)
- UniSTS:257058

Taf1 (e-PCR), detects polymorphism
- UniSTS:547632

px-35c7 (e-PCR)
- UniSTS:257629

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

GDB:194744 (e-PCR)
- UniSTS:155800

AU015687 (e-PCR)
- UniSTS:207809

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to H3K27me3 modified histone binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase I general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II general transcription initiation factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transcription regulator inhibitor activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
colocalizes_with nucleolus	ISO Inferred from Sequence Orthology more info
colocalizes_with nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pronucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription initiation factor TFIID subunit 1

Names: TBP-associated factor 250 kDa; cell cycle gene 1 protein; cell cycle, G1 phase defect; transcription initiation factor TFIID 250 kDa subunit

NP_001277658.2

EC 2.3.1.48

EC 2.7.11.1

NP_001392888.2

EC 2.3.1.48

EC 2.7.11.1

NP_001392889.2

EC 2.3.1.48

EC 2.7.11.1

NP_001392890.2

EC 2.3.1.48

EC 2.7.11.1

NP_001392891.2

EC 2.3.1.48

EC 2.7.11.1

XP_006528114.1

EC 2.3.1.48

EC 2.7.11.1

XP_017174001.1

EC 2.3.1.48

EC 2.7.11.1

XP_017174002.1

EC 2.3.1.48

EC 2.7.11.1

XP_017174004.1

EC 2.3.1.48

EC 2.7.11.1

XP_017174005.1

EC 2.3.1.48

EC 2.7.11.1

XP_017174007.1

EC 2.3.1.48

EC 2.7.11.1

XP_036017866.1

EC 2.3.1.48

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290729.3 → NP_001277658.2 transcription initiation factor TFIID subunit 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL806534, AL831722

Consensus CDS

CCDS85793.1

Related

ENSMUSP00000114765.3, ENSMUST00000149274.9
NM_001405959.2 → NP_001392888.2 transcription initiation factor TFIID subunit 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL806534, AL831722

Related

ENSMUSP00000138159.2, ENSMUST00000143908.8
NM_001405960.2 → NP_001392889.2 transcription initiation factor TFIID subunit 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL806534, AL831722

Related

ENSMUSP00000112772.2, ENSMUST00000118878.8
NM_001405961.2 → NP_001392890.2 transcription initiation factor TFIID subunit 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL806534, AL831722
NM_001405962.2 → NP_001392891.2 transcription initiation factor TFIID subunit 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL806534, AL831722

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

100576335..100644635

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161973.1 → XP_036017866.1 transcription initiation factor TFIID subunit 1 isoform X9

UniProtKB/TrEMBL

S4R1B9

Conserved Domains (4) summary

cd05511
Location:1533 → 1645

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:28 → 86

TBP-binding; TATA box-binding protein binding

pfam12157
Location:591 → 1054

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1287 → 1322

zf-CCHC_6; Zinc knuckle
XM_017318518.3 → XP_017174007.1 transcription initiation factor TFIID subunit 1 isoform X10

UniProtKB/TrEMBL

S4R1B9

Conserved Domains (5) summary

cd05511
Location:1411 → 1522

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:28 → 86

TBP-binding; TATA box-binding protein binding

pfam12157
Location:591 → 1054

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1287 → 1322

zf-CCHC_6; Zinc knuckle

cl02556
Location:1533 → 1612

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_017318512.2 → XP_017174001.1 transcription initiation factor TFIID subunit 1 isoform X1

UniProtKB/TrEMBL

A0A067XG50, B1Q2W7

Conserved Domains (4) summary

cd05511
Location:1533 → 1645

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:28 → 86

TBP-binding; TATA box-binding protein binding

pfam12157
Location:591 → 1054

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1287 → 1322

zf-CCHC_6; Zinc knuckle
XM_017318515.3 → XP_017174004.1 transcription initiation factor TFIID subunit 1 isoform X6

UniProtKB/TrEMBL

A0A067XG50, B1Q2W7

Conserved Domains (4) summary

cd05511
Location:1533 → 1645

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:28 → 86

TBP-binding; TATA box-binding protein binding

pfam12157
Location:591 → 1054

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1287 → 1322

zf-CCHC_6; Zinc knuckle
XM_017318513.3 → XP_017174002.1 transcription initiation factor TFIID subunit 1 isoform X2

UniProtKB/Swiss-Prot

A2AM32, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q80UV9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1

Conserved Domains (4) summary

cd05511
Location:1533 → 1645

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:28 → 86

TBP-binding; TATA box-binding protein binding

pfam12157
Location:591 → 1054

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1287 → 1322

zf-CCHC_6; Zinc knuckle
XM_017318516.3 → XP_017174005.1 transcription initiation factor TFIID subunit 1 isoform X7

UniProtKB/Swiss-Prot

A2AM32, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q80UV9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1

Conserved Domains (4) summary

cd05511
Location:1533 → 1645

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:28 → 86

TBP-binding; TATA box-binding protein binding

pfam12157
Location:591 → 1054

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1287 → 1322

zf-CCHC_6; Zinc knuckle
XM_006528051.4 → XP_006528114.1 transcription initiation factor TFIID subunit 1 isoform X4

UniProtKB/TrEMBL

A0A067XG50, B1Q2W7

Conserved Domains (4) summary

cd05511
Location:1507 → 1619

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:28 → 86

TBP-binding; TATA box-binding protein binding

pfam12157
Location:565 → 1028

DUF3591; Protein of unknown function (DUF3591)

pfam15288
Location:1261 → 1296

zf-CCHC_6; Zinc knuckle

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001081008.1: Suppressed sequence

Description

NM_001081008.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.