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    Tbx4 T-box 4 [ Mus musculus (house mouse) ]

    Gene ID: 21387, updated on 22-Aug-2021

    Summary

    Official Symbol
    Tbx4provided by MGI
    Official Full Name
    T-box 4provided by MGI
    Primary source
    MGI:MGI:102556
    See related
    Ensembl:ENSMUSG00000000094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3930401C23
    Expression
    Biased expression in lung adult (RPKM 26.7), limb E14.5 (RPKM 11.0) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Tbx4 in Genome Data Viewer
    Location:
    11 C; 11 51.42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (85777193..85806923)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (85886367..85916097)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (85703565..85729599)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1583 Neighboring gene HLEA enhancer upstream of Tbx4 Neighboring gene Tbx4 lung enhancer Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene HLEB enhancer downstream of Tbx4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in embryonic hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic lung development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within limb morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in limb morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal system morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    T-box transcription factor TBX4
    Names
    T-box protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011536.3NP_035666.2  T-box transcription factor TBX4 isoform a

      See identical proteins and their annotated locations for NP_035666.2

      Status: VALIDATED

      Source sequence(s)
      AL592465
      Consensus CDS
      CCDS25196.1
      UniProtKB/Swiss-Prot
      P70325
      UniProtKB/TrEMBL
      Q8BSY3
      Related
      ENSMUSP00000103682.2, ENSMUST00000108047.8
      Conserved Domains (1) summary
      cd00182
      Location:71260
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    2. NM_172798.1NP_766386.1  T-box transcription factor TBX4 isoform b

      See identical proteins and their annotated locations for NP_766386.1

      Status: VALIDATED

      Source sequence(s)
      AK028407, BB755063, BQ560189
      Consensus CDS
      CCDS48874.1
      UniProtKB/TrEMBL
      Q8BSY3
      Related
      ENSMUSP00000103680.3, ENSMUST00000108045.3
      Conserved Domains (1) summary
      cd00182
      Location:1160
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      85777193..85806923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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