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    Kifc5b kinesin family member C5B [ Mus musculus (house mouse) ]

    Gene ID: 16580, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Kifc5bprovided by MGI
    Official Full Name
    kinesin family member C5Bprovided by MGI
    Primary source
    MGI:MGI:2137414
    See related
    Ensembl:ENSMUSG00000024301 AllianceGenome:MGI:2137414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hset; KNSL2; Kifc5a
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement; mitotic metaphase plate congression; and mitotic spindle assembly. Predicted to be part of kinesin complex. Predicted to be active in microtubule cytoskeleton and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human KIFC1 (kinesin family member C1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 18.8), liver E14.5 (RPKM 13.5) and 18 other tissues See more
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    Genomic context

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    Location:
    17 A3.3; 17 13.6 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27136065..27151553)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26917091..26932579)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17382 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene predicted gene, 41555 Neighboring gene STARR-seq mESC enhancer starr_42135 Neighboring gene STARR-seq mESC enhancer starr_42137 Neighboring gene microRNA 6967-1 Neighboring gene STARR-positive B cell enhancer ABC_E487 Neighboring gene microRNA 6968 Neighboring gene PHD finger protein 1 Neighboring gene cutA divalent cation tolerance homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of isoforms of a mitotic motor in mammalian spermatogenesis. Navolanic PM, et al. Biol Reprod, 2000 May. PMID 10775188
    2. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Saito N, et al. Neuron, 1997 Mar. PMID 9115736
    3. Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Rousseaux MW, et al. Proc Natl Acad Sci U S A, 2012 Sep 25. PMID 23019375, Free PMC Article
    4. Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication. Christodoulou A, et al. J Cell Sci, 2006 May 15. PMID 16638812
    5. Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver. Nath S, et al. Mol Biol Cell, 2007 May. PMID 17360972, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIFC5A and the Nubp proteins in a common regulatory pathway involved in the control of centrosome duplication in mammalian cells.
      Title: Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC76666

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin family member C5B
    Names
    kinesin family c-terminal 5A
    kinesin family c-terminal 5B
    kinesin family member C5A
    kinesin-related protein KIFC5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053173.2 → NP_444403.2  kinesin family member C5B

      Status: VALIDATED

      Source sequence(s)
      AC144621, AF221103, AI604818, AK081484, BB638629, BI733451
      Consensus CDS
      CCDS37517.1
      UniProtKB/TrEMBL
      A0A068BFR6, E9PUA5
      Related
      ENSMUSP00000077984.5, ENSMUST00000078961.6
      Conserved Domains (4) summary
      smart00129
      Location:309 → 665
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01366
      Location:307 → 664
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam07926
      Location:138 → 249
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam15233
      Location:169 → 298
      SYCE1; Synaptonemal complex central element protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      27136065..27151553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016761.1: Suppressed sequence

      Description
      NM_016761.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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