Itk IL2 inducible T cell kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itkprovided by MGI
Official Full Name: IL2 inducible T cell kinaseprovided by MGI
Primary source: MGI:MGI:96621
See related: Ensembl:ENSMUSG00000020395 AllianceGenome:MGI:96621
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Emt; Tsk; Tcsk
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including T cell receptor signaling pathway; activation of phospholipase C activity; and gamma-delta T cell activation. Acts upstream of or within NK T cell differentiation. Located in cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 35.8), spleen adult (RPKM 4.7) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 11 B1.1; 11 27.75 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (46215975..46280342, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (46325148..46389515, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of ITK Signaling Causes Amelioration in Sepsis-Associated Neuroinflammation and Depression-like State in Mice.
Title: Inhibition of ITK Signaling Causes Amelioration in Sepsis-Associated Neuroinflammation and Depression-like State in Mice.
Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer.
Title: Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer.
The Tec Kinase Itk Integrates Naive T Cell Migration and In Vivo Homeostasis.
Title: The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis.
Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK.
Title: Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK.
Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads.
Title: Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads.
Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT.
Title: Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT.
Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection.
Title: Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection.
CD8(+) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine.
Title: CD8(+) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine.
Ibrutinib suppressed phosphorylation of BTK in neutrophils at lower doses and ITK in CD4+T cells at higher doses in CE-treated mice.
Title: Inhibition of Bruton's tyrosine kinase and IL-2 inducible T-cell kinase suppresses both neutrophilic and eosinophilic airway inflammation in a cockroach allergen extract-induced mixed granulocytic mouse model of asthma using preventative and therapeutic strategy.
Inhibition of ITK and RLK attenuated psoriasis-associated signaling pathways, indicating that PRN694 is an effective psoriasis therapeutic.
Title: ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse Models of Psoriasis.

Submit: New GeneRIF Correction See all GeneRIFs (86)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Chemically induced (ENU) (2)
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in NK T cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within NK T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within NK T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of phospholipase C activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-delta T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interleukin-4 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase ITK/TSK

Names: T-cell-specific kinase; interleukin-2-inducible T cell kinase; kinase TLK

NP_001268894.1

EC 2.7.10.2

NP_001268895.1

EC 2.7.10.2

NP_001268896.1

EC 2.7.10.2

NP_001268897.1

EC 2.7.10.2

NP_034713.2

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281965.1 → NP_001268894.1 tyrosine-protein kinase ITK/TSK isoform 1

See identical proteins and their annotated locations for NP_001268894.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK153613, AL662806, BB843988, BY589043, D14042

Consensus CDS

CCDS70169.1

UniProtKB/Swiss-Prot

Q03526

UniProtKB/TrEMBL

Q3U5G1

Related

ENSMUSP00000104860.3, ENSMUST00000109237.9

Conserved Domains (4) summary

cd05112
Location:363 → 618

PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase

cd10396
Location:238 → 345

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11908
Location:180 → 235

SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase

cd01238
Location:7 → 154

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
NM_001281966.1 → NP_001268895.1 tyrosine-protein kinase ITK/TSK isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AK153613, BB843988, BY589043, D14042

UniProtKB/TrEMBL

Q3U5G1

Conserved Domains (4) summary

cd05112
Location:360 → 615

PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase

cd10396
Location:235 → 342

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11908
Location:177 → 232

SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase

cd01238
Location:7 → 148

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
NM_001281967.1 → NP_001268896.1 tyrosine-protein kinase ITK/TSK isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

BB843988, BC028478

Consensus CDS

CCDS70168.1

UniProtKB/TrEMBL

Q5STT7

Related

ENSMUSP00000098864.4, ENSMUST00000101306.4

Conserved Domains (4) summary

cd11908
Location:174 → 229

SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase

cd01238
Location:7 → 148

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

pfam00169
Location:5 → 111

PH; PH domain

cl15255
Location:232 → 259

SH2; Src homology 2 (SH2) domain
NM_001281968.1 → NP_001268897.1 tyrosine-protein kinase ITK/TSK isoform 5

See identical proteins and their annotated locations for NP_001268897.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (5) is shorter, compared to isoform 1.

Source sequence(s)

AK153613, BB843988, BY589043, D14042

UniProtKB/TrEMBL

A1A560, Q3U5G1

Conserved Domains (4) summary

cd05112
Location:356 → 611

PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase

cd10396
Location:231 → 338

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11908
Location:173 → 228

SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase

cd01238
Location:7 → 147

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
NM_010583.3 → NP_034713.2 tyrosine-protein kinase ITK/TSK isoform 2

See identical proteins and their annotated locations for NP_034713.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK153613, BB843988, BY589043, D14042

Consensus CDS

CCDS24575.2

UniProtKB/TrEMBL

Q3U5G1, Q5STT8

Related

ENSMUSP00000020664.7, ENSMUST00000020664.13

Conserved Domains (4) summary

cd05112
Location:357 → 612

PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase

cd10396
Location:232 → 339

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11908
Location:174 → 229

SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase

cd01238
Location:7 → 148

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain