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    Bcas3 BCAS3 microtubule associated cell migration factor [ Mus musculus (house mouse) ]

    Gene ID: 192197, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Bcas3provided by MGI
    Official Full Name
    BCAS3 microtubule associated cell migration factorprovided by MGI
    Primary source
    MGI:MGI:2385848
    See related
    Ensembl:ENSMUSG00000059439 AllianceGenome:MGI:2385848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K20D4; Phaf2; rudhira; 1500019F07Rik; 2610028P08Rik
    Summary
    Predicted to enable several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and histone acetyltransferase binding activity. Involved in several processes, including negative regulation of focal adhesion assembly; positive regulation of cellular component organization; and regulation of GTPase activity. Located in cell leading edge; cell periphery; and cytoskeleton. Is expressed in several structures, including cardiovascular system; embryo mesenchyme; genitourinary system; hemolymphoid system; and yolk sac. Orthologous to human BCAS3 (BCAS3 microtubule associated cell migration factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 3.3), kidney adult (RPKM 3.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 C; 11 51.34 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (85243611..85716884)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (85353110..85826058)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30238 Neighboring gene STARR-seq mESC enhancer starr_30241 Neighboring gene amyloid beta precursor protein binding protein 2, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E593 Neighboring gene STARR-positive B cell enhancer ABC_E303 Neighboring gene protein phosphatase 1D magnesium-dependent, delta isoform Neighboring gene STARR-seq mESC enhancer starr_30248 Neighboring gene STARR-seq mESC enhancer starr_30251 Neighboring gene limb enhancer upstream of Tbx2 Neighboring gene STARR-seq mESC enhancer starr_30253 Neighboring gene BCAS3 microtubule associated cell migration factor, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_30254 Neighboring gene RIKEN cDNA 2610027K06 gene Neighboring gene STARR-seq mESC enhancer starr_30255 Neighboring gene BCAS3 microtubule associated cell migration factor, opposite strand 2 Neighboring gene microRNA 5110 Neighboring gene Tbx2 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_30256 Neighboring gene VISTA enhancer mm1583 Neighboring gene HLEA enhancer upstream of Tbx4 Neighboring gene Tbx4 lung enhancer Neighboring gene T-box 2 Neighboring gene T-box 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis. Jain M, et al. Exp Cell Res, 2012 Apr 1. PMID 22300583
    2. Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis. Siva K, et al. Gene Expr Patterns, 2006 Jan. PMID 16099728
    3. Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning. Shetty R, et al. Sci Rep, 2018 Apr 4. PMID 29618843, Free PMC Article
    4. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Gobert RP, et al. Mol Cell Biol, 2009 Mar. PMID 19139271, Free PMC Article
    5. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expressed at high levels in embryonic stem cells and is restricted to blood islands and the erythroid lineage during embryonic development
      Title: Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetyltransferase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to estrogen stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagophore assembly site ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BCAS3 microtubule associated cell migration factor
    Names
    breast carcinoma amplified sequence 3
    breast carcinoma-amplified sequence 3 homolog
    protein rudhira

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166642.1 → NP_001160114.1  BCAS3 microtubule associated cell migration factor isoform b

      See identical proteins and their annotated locations for NP_001160114.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform.
      Source sequence(s)
      AK032423, BC060690, BX323026, BY116917, CN711546
      Consensus CDS
      CCDS48873.1
      UniProtKB/TrEMBL
      Q0VF62, Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:521 → 749
      BCAS3; Breast carcinoma amplified sequence 3

    2. NM_001166643.1 → NP_001160115.1  BCAS3 microtubule associated cell migration factor isoform b

      See identical proteins and their annotated locations for NP_001160115.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform.
      Source sequence(s)
      AL604024, BC060690, BC086693, BY116917
      Consensus CDS
      CCDS48873.1
      UniProtKB/TrEMBL
      Q0VF62, Q3TAC0
      Related
      ENSMUSP00000090496.4, ENSMUST00000092821.10
      Conserved Domains (1) summary
      pfam12490
      Location:521 → 749
      BCAS3; Breast carcinoma amplified sequence 3

    3. NM_138681.4 → NP_619622.3  BCAS3 microtubule associated cell migration factor isoform a

      See identical proteins and their annotated locations for NP_619622.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK032423, BC060690, BX323026, BY116917, CN711546
      Consensus CDS
      CCDS25195.1
      UniProtKB/Swiss-Prot
      Q8CC16, Q8CCN5, Q9EPX3
      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:581 → 764
      BCAS3; Breast carcinoma amplified sequence 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      85243611..85716884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245680.2 → XP_030101540.1  BCAS3 microtubule associated cell migration factor isoform X1

      Conserved Domains (1) summary
      pfam12490
      Location:594 → 777
      BCAS3; Breast carcinoma amplified sequence 3

    2. XM_030245681.2 → XP_030101541.1  BCAS3 microtubule associated cell migration factor isoform X2

      Conserved Domains (1) summary
      pfam12490
      Location:581 → 764
      BCAS3; Breast carcinoma amplified sequence 3

    3. XM_006532541.3 → XP_006532604.1  BCAS3 microtubule associated cell migration factor isoform X19

      See identical proteins and their annotated locations for XP_006532604.1

      UniProtKB/TrEMBL
      Q0VF62, Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:521 → 749
      BCAS3; Breast carcinoma amplified sequence 3

    4. XM_036156433.1 → XP_036012326.1  BCAS3 microtubule associated cell migration factor isoform X2

      Conserved Domains (1) summary
      pfam12490
      Location:581 → 764
      BCAS3; Breast carcinoma amplified sequence 3

    5. XM_030245679.2 → XP_030101539.1  BCAS3 microtubule associated cell migration factor isoform X1

      Conserved Domains (1) summary
      pfam12490
      Location:594 → 777
      BCAS3; Breast carcinoma amplified sequence 3

    6. XM_036156436.1 → XP_036012329.1  BCAS3 microtubule associated cell migration factor isoform X11

      UniProtKB/TrEMBL
      B1AR74, Q3TAC0
      Related
      ENSMUSP00000103697.2, ENSMUST00000108062.8
      Conserved Domains (1) summary
      pfam12490
      Location:581 → 764
      BCAS3; Breast carcinoma amplified sequence 3

    7. XM_030245687.1 → XP_030101547.1  BCAS3 microtubule associated cell migration factor isoform X8

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:581 → 764
      BCAS3; Breast carcinoma amplified sequence 3

    8. XM_030245689.1 → XP_030101549.1  BCAS3 microtubule associated cell migration factor isoform X17

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:581 → 764
      BCAS3; Breast carcinoma amplified sequence 3

    9. XM_006532540.3 → XP_006532603.1  BCAS3 microtubule associated cell migration factor isoform X15

      See identical proteins and their annotated locations for XP_006532603.1

      UniProtKB/Swiss-Prot
      Q8CC16, Q8CCN5, Q9EPX3
      UniProtKB/TrEMBL
      Q3TAC0
      Related
      ENSMUSP00000074416.5, ENSMUST00000074875.11
      Conserved Domains (1) summary
      pfam12490
      Location:581 → 764
      BCAS3; Breast carcinoma amplified sequence 3

    10. XM_030245685.2 → XP_030101545.1  BCAS3 microtubule associated cell migration factor isoform X5

      Conserved Domains (1) summary
      pfam12490
      Location:521 → 749
      BCAS3; Breast carcinoma amplified sequence 3

    11. XM_017314342.2 → XP_017169831.1  BCAS3 microtubule associated cell migration factor isoform X14

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:521 → 749
      BCAS3; Breast carcinoma amplified sequence 3

    12. XM_030245688.1 → XP_030101548.1  BCAS3 microtubule associated cell migration factor isoform X12

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:521 → 749
      BCAS3; Breast carcinoma amplified sequence 3

    13. XM_036156438.1 → XP_036012331.1  BCAS3 microtubule associated cell migration factor isoform X20

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:521 → 749
      BCAS3; Breast carcinoma amplified sequence 3

    14. XM_030245678.2 → XP_030101538.1  BCAS3 microtubule associated cell migration factor isoform X1

      Conserved Domains (1) summary
      pfam12490
      Location:594 → 777
      BCAS3; Breast carcinoma amplified sequence 3

    15. XM_036156434.1 → XP_036012327.1  BCAS3 microtubule associated cell migration factor isoform X4

      Conserved Domains (1) summary
      pfam12490
      Location:594 → 777
      BCAS3; Breast carcinoma amplified sequence 3

    16. XM_030245684.2 → XP_030101544.1  BCAS3 microtubule associated cell migration factor isoform X2

      Conserved Domains (1) summary
      pfam12490
      Location:581 → 764
      BCAS3; Breast carcinoma amplified sequence 3

    17. XM_030245682.2 → XP_030101542.1  BCAS3 microtubule associated cell migration factor isoform X3

      Conserved Domains (1) summary
      pfam12490
      Location:534 → 762
      BCAS3; Breast carcinoma amplified sequence 3

    18. XM_011248810.4 → XP_011247112.1  BCAS3 microtubule associated cell migration factor isoform X21

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:594 → 777
      BCAS3; Breast carcinoma amplified sequence 3

    19. XM_030245686.2 → XP_030101546.1  BCAS3 microtubule associated cell migration factor isoform X5

      Conserved Domains (1) summary
      pfam12490
      Location:521 → 749
      BCAS3; Breast carcinoma amplified sequence 3

    20. XM_006532542.5 → XP_006532605.1  BCAS3 microtubule associated cell migration factor isoform X22

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:594 → 777
      BCAS3; Breast carcinoma amplified sequence 3

    21. XM_006532537.5 → XP_006532600.1  BCAS3 microtubule associated cell migration factor isoform X7

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:594 → 777
      BCAS3; Breast carcinoma amplified sequence 3

    22. XM_006532539.4 → XP_006532602.1  BCAS3 microtubule associated cell migration factor isoform X13

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:594 → 777
      BCAS3; Breast carcinoma amplified sequence 3

    23. XM_006532536.5 → XP_006532599.1  BCAS3 microtubule associated cell migration factor isoform X6

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:594 → 777
      BCAS3; Breast carcinoma amplified sequence 3

    24. XM_006532538.4 → XP_006532601.1  BCAS3 microtubule associated cell migration factor isoform X10

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:594 → 777
      BCAS3; Breast carcinoma amplified sequence 3

    25. XM_036156435.1 → XP_036012328.1  BCAS3 microtubule associated cell migration factor isoform X9

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:534 → 762
      BCAS3; Breast carcinoma amplified sequence 3

    26. XM_036156437.1 → XP_036012330.1  BCAS3 microtubule associated cell migration factor isoform X18

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:534 → 762
      BCAS3; Breast carcinoma amplified sequence 3

    27. XM_017314343.1 → XP_017169832.1  BCAS3 microtubule associated cell migration factor isoform X16

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:534 → 762
      BCAS3; Breast carcinoma amplified sequence 3

    28. XM_036156439.1 → XP_036012332.1  BCAS3 microtubule associated cell migration factor isoform X20

      UniProtKB/TrEMBL
      Q3TAC0
      Conserved Domains (1) summary
      pfam12490
      Location:521 → 749
      BCAS3; Breast carcinoma amplified sequence 3

    RNA

    1. XR_001779924.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CCN5.2 GenPept UniProtKB/Swiss-Prot:Q8CCN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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