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    Slc25a53 solute carrier family 25, member 53 [ Mus musculus (house mouse) ]

    Gene ID: 67062, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slc25a53provided by MGI
    Official Full Name
    solute carrier family 25, member 53provided by MGI
    Primary source
    MGI:MGI:1914312
    See related
    Ensembl:ENSMUSG00000044348 AllianceGenome:MGI:1914312
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcart6; 2310046F18Rik; 2810402A17Rik
    Summary
    Orthologous to human SLC25A53 (solute carrier family 25 member 53). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 2.0), whole brain E14.5 (RPKM 1.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X F1; X 59.1 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135881865..135939051, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136981116..137038302, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene thymosin beta 15b2 Neighboring gene thymosin beta 15b like Neighboring gene thymosin beta 15b1 Neighboring gene zinc finger, CCHC domain containing 18 Neighboring gene vacuolar ATPase assembly integral membrane protein Vma21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47980 Neighboring gene family with sequence similarity 199, X-linked Neighboring gene predicted gene, 25770

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Gu G, et al. Development, 2004 Jan. PMID 14660441
    2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 25 member 53
    Names
    mitochondrial carrier triple repeat 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082412.2 → NP_001075881.1  solute carrier family 25 member 53 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001075881.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI448995, AK012963, AK076279, AL672008, CX240158
      Consensus CDS
      CCDS41140.1
      UniProtKB/TrEMBL
      A2AF28
      Related
      ENSMUSP00000108692.3, ENSMUST00000113069.9
      Conserved Domains (1) summary
      pfam00153
      Location:150 → 243
      Mito_carr; Mitochondrial carrier protein

    2. NM_001114179.1 → NP_001107651.1  solute carrier family 25 member 53 isoform 2

      See identical proteins and their annotated locations for NP_001107651.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AI448995, AL672008, CX240158
      Consensus CDS
      CCDS53198.1
      UniProtKB/TrEMBL
      E9PZF7
      Related
      ENSMUSP00000132572.2, ENSMUST00000171738.2
      Conserved Domains (1) summary
      pfam00153
      Location:113 → 203
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      135881865..135939051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247758.2 → XP_011246060.2  solute carrier family 25 member 53 isoform X1

      Conserved Domains (1) summary
      pfam00153
      Location:156 → 249
      Mito_carr; Mitochondrial carrier protein

    2. XM_006528599.5 → XP_006528662.1  solute carrier family 25 member 53 isoform X2

      See identical proteins and their annotated locations for XP_006528662.1

      UniProtKB/TrEMBL
      E9PZF7
      Conserved Domains (1) summary
      pfam00153
      Location:113 → 203
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version

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