Brd3 bromodomain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brd3provided by MGI
Official Full Name: bromodomain containing 3provided by MGI
Primary source: MGI:MGI:1914632
See related: Ensembl:ENSMUSG00000026918 AllianceGenome:MGI:1914632
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ORFX; Fsrg2; RINGL3; 2410084F24Rik
Summary: Predicted to enable lysine-acetylated histone binding activity and nucleosomal histone binding activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and retina. Orthologous to human BRD3 (bromodomain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 15.9), limb E14.5 (RPKM 14.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.38 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (27335588..27397669, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (27445576..27507657, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using pharmacological assay and RNA interference, BRD3 down-regulation resulted in enhanced myogenic differentiation.
Title: BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis.
Brd3 knockout significantly decreased the recruitment of acetylase CBP to IL6 gene promoter, and the acetylation level of histone3 within IL6 gene promoter was repressed.
Title: [Brd3 promotes IL-6 production via enhancing acetylase CBP recruitment and histone 3 acetylation within IL6 promoter].
Data show that infection of macrophages with Listeria monocytogenes caused binding of the BET proteins Brd2, Brd3, and, most prominently, Brd4 to the Nos2 promoter.
Title: Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins.
Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes
Title: Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes.
A conserved but uncharacterized gene encoding Brd3, which was down-regulated during endothelial differentiation, was identified.
Title: Differentially expressed genes in endothelial differentiation.
more strongly expressed in developing testis compared with ovary
Title: Pre-sertoli specific gene expression profiling reveals differential expression of Ppt1 and Brd3 genes within the mouse genital ridge at the time of sex determination.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133905 (e-PCR)
- UniSTS:217188

UniSTS:234347 (e-PCR)
- UniSTS:234347

AW060456 (e-PCR)
- UniSTS:178592

Brd3 (e-PCR), detects polymorphism
- UniSTS:536517

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endodermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bromodomain-containing protein 3

Names: bromodomain-containing FSH-like protein FSRG2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113573.1 → NP_001107045.1 bromodomain-containing protein 3 isoform 2

See identical proteins and their annotated locations for NP_001107045.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an internal coding exon, as compared to vairant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AK034797, AK079666, AK160752, BM899753, BY064662

Consensus CDS

CCDS15828.1

UniProtKB/Swiss-Prot

Q8C665, Q8CAX7, Q8K2F0, Q9JI25

UniProtKB/TrEMBL

Q3TUI3, Q4G5Y4

Related

ENSMUSP00000076918.7, ENSMUST00000077737.13

Conserved Domains (3) summary

cd05497
Location:33 → 139

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:310 → 411

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:572 → 636

BET; Bromodomain extra-terminal - transcription regulation
NM_001113574.1 → NP_001107046.1 bromodomain-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_001107046.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK034797, AK037435, AK076472, AK079666, AK160752, BM899753, BY064662

Consensus CDS

CCDS50546.1

UniProtKB/TrEMBL

A2AKA9, Q5CCJ9

Related

ENSMUSP00000109574.3, ENSMUST00000113941.9

Conserved Domains (3) summary

cd05497
Location:33 → 139

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:310 → 411

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:589 → 653

BET; Bromodomain extra-terminal - transcription regulation
NM_023336.4 → NP_075825.3 bromodomain-containing protein 3 isoform 2

See identical proteins and their annotated locations for NP_075825.3

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate 5' UTR and lacks an internal coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AK034797, AK079666, AK160752, BE981816, BM899753, CN530570

Consensus CDS

CCDS15828.1

UniProtKB/Swiss-Prot

Q8C665, Q8CAX7, Q8K2F0, Q9JI25

UniProtKB/TrEMBL

Q3TUI3, Q4G5Y4

Related

ENSMUSP00000028282.9, ENSMUST00000028282.15

Conserved Domains (3) summary

cd05497
Location:33 → 139

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:310 → 411

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:572 → 636

BET; Bromodomain extra-terminal - transcription regulation

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

27335588..27397669 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498250.2 → XP_006498313.1 bromodomain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006498313.1

UniProtKB/TrEMBL

A2AKA9, Q5CCJ9

Related

ENSMUSP00000114422.2, ENSMUST00000154316.8

Conserved Domains (3) summary

cd05497
Location:33 → 139

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:310 → 411

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:589 → 653

BET; Bromodomain extra-terminal - transcription regulation
XM_006498249.5 → XP_006498312.1 bromodomain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006498312.1

UniProtKB/TrEMBL

A2AKA9, Q5CCJ9

Conserved Domains (3) summary

cd05497
Location:33 → 139

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:310 → 411

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:589 → 653

BET; Bromodomain extra-terminal - transcription regulation
XM_011239156.4 → XP_011237458.1 bromodomain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_011237458.1

UniProtKB/TrEMBL

A2AKA9, Q5CCJ9

Conserved Domains (3) summary

cd05497
Location:33 → 139

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:310 → 411

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:589 → 653

BET; Bromodomain extra-terminal - transcription regulation
XM_011239155.2 → XP_011237457.1 bromodomain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_011237457.1

UniProtKB/TrEMBL

A2AKA9, Q5CCJ9

Conserved Domains (3) summary

cd05497
Location:33 → 139

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:310 → 411

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:589 → 653

BET; Bromodomain extra-terminal - transcription regulation
XM_011239158.4 → XP_011237460.1 bromodomain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_011237460.1

UniProtKB/TrEMBL

A2AKA9, Q5CCJ9

Conserved Domains (3) summary

cd05497
Location:33 → 139

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:310 → 411

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:589 → 653

BET; Bromodomain extra-terminal - transcription regulation
XM_011239159.2 → XP_011237461.1 bromodomain-containing protein 3 isoform X3

Conserved Domains (2) summary

cd05498
Location:1 → 91

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:269 → 333

BET; Bromodomain extra-terminal - transcription regulation
XM_030251992.2 → XP_030107852.1 bromodomain-containing protein 3 isoform X4

Conserved Domains (2) summary

cd05498
Location:1 → 91

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:252 → 316

BET; Bromodomain extra-terminal - transcription regulation
XM_030251991.2 → XP_030107851.1 bromodomain-containing protein 3 isoform X2

UniProtKB/Swiss-Prot

Q8C665, Q8CAX7, Q8K2F0, Q9JI25

UniProtKB/TrEMBL

Q3TUI3, Q4G5Y4

Related

ENSMUSP00000128812.2, ENSMUST00000164296.8

Conserved Domains (3) summary

cd05497
Location:33 → 139

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:310 → 411

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:572 → 636

BET; Bromodomain extra-terminal - transcription regulation