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    Dnajc21 DnaJ heat shock protein family (Hsp40) member C21 [ Mus musculus (house mouse) ]

    Gene ID: 78244, updated on 9-May-2024

    Summary

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    Official Symbol
    Dnajc21provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C21provided by MGI
    Primary source
    MGI:MGI:1925371
    See related
    Ensembl:ENSMUSG00000044224 AllianceGenome:MGI:1925371
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930461P20Rik; 9930116P15Rik
    Summary
    Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm. Is expressed in blastocyst and genitourinary system. Orthologous to human DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 8.2), cortex adult (RPKM 5.6) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajc21 in Genome Data Viewer
    Location:
    15 A1; 15 5.35 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10446849..10470685, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10446763..10470568, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene alanine-glyoxylate aminotransferase 2 Neighboring gene predicted gene, 52213 Neighboring gene STARR-positive B cell enhancer ABC_E9414 Neighboring gene BRX1, biogenesis of ribosomes Neighboring gene STARR-seq mESC enhancer starr_37954 Neighboring gene RAD1 checkpoint DNA exonuclease Neighboring gene tetratricopeptide repeat domain 23-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
    2. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 21
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030046.3 → NP_084322.2  dnaJ homolog subfamily C member 21

      Status: VALIDATED

      Source sequence(s)
      AC102101
      Consensus CDS
      CCDS49581.1
      UniProtKB/Swiss-Prot
      E9Q8D0, Q3USP3
      Related
      ENSMUSP00000116865.2, ENSMUST00000136591.8
      Conserved Domains (4) summary
      sd00020
      Location:316 → 338
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00226
      Location:3 → 66
      DnaJ; DnaJ domain
      pfam12171
      Location:314 → 339
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13892
      Location:181 → 243
      DBINO; DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      10446849..10470685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316801.3 → XP_017172290.1  dnaJ homolog subfamily C member 21 isoform X1

      Conserved Domains (5) summary
      PTZ00121
      Location:167 → 455
      PTZ00121; MAEBL; Provisional
      COG5269
      Location:4 → 267
      ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
      PRK10767
      Location:2 → 66
      PRK10767; chaperone protein DnaJ; Provisional
      sd00020
      Location:316 → 338
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:314 → 339
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    2. XM_036159635.1 → XP_036015528.1  dnaJ homolog subfamily C member 21 isoform X2

      Conserved Domains (4) summary
      PTZ00121
      Location:56 → 346
      PTZ00121; MAEBL; Provisional
      COG5269
      Location:23 → 142
      ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
      sd00020
      Location:191 → 213
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:189 → 214
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    3. XM_036159634.1 → XP_036015527.1  dnaJ homolog subfamily C member 21 isoform X2

      Conserved Domains (4) summary
      PTZ00121
      Location:56 → 346
      PTZ00121; MAEBL; Provisional
      COG5269
      Location:23 → 142
      ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
      sd00020
      Location:191 → 213
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:189 → 214
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q8D0.1 GenPept UniProtKB/Swiss-Prot:E9Q8D0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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