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    Ermp1 endoplasmic reticulum metallopeptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 226090, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ermp1provided by MGI
    Official Full Name
    endoplasmic reticulum metallopeptidase 1provided by MGI
    Primary source
    MGI:MGI:106250
    See related
    Ensembl:ENSMUSG00000046324 AllianceGenome:MGI:106250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fxna; D19Wsu12e; mKIAA1815; b2b2633Clo; D19Ertd410e
    Summary
    Predicted to enable metal ion binding activity and metallopeptidase activity. Predicted to be involved in cellular response to oxidative stress; ovarian follicle development; and proteolysis. Predicted to act upstream of or within endoplasmic reticulum unfolded protein response. Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and sensory organ. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 65.2), genital fat pad adult (RPKM 14.2) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C1; 19 24.17 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29587276..29625815, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29609876..29648415, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930007I19 gene Neighboring gene STARR-positive B cell enhancer ABC_E8745 Neighboring gene RAB6A GEF complex partner 1 Neighboring gene STARR-seq mESC enhancer starr_45891 Neighboring gene predicted gene, 36126 Neighboring gene STARR-seq mESC enhancer starr_45893 Neighboring gene melan-A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis. Garcia-Rudaz C, et al. Development, 2007 Mar. PMID 17267443
    2. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657
    3. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
    4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    5. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional analysis of the rat Fxna ortholog.
      Title: Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Chemically induced (ENU) (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28180

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloexopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum metallopeptidase 1
    Names
    aminopeptidase Fxna
    felix-ina

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081213.2 → NP_001074682.1  endoplasmic reticulum metallopeptidase 1 isoform 1

      See identical proteins and their annotated locations for NP_001074682.1

      Status: VALIDATED

      Source sequence(s)
      AC114578
      Consensus CDS
      CCDS37952.1
      UniProtKB/Swiss-Prot
      B2RXD6, Q3UVK0, Q6ZPH9, Q8BIW0, Q8BYX7
      Related
      ENSMUSP00000124881.2, ENSMUST00000159692.8
      Conserved Domains (1) summary
      cd03875
      Location:99 → 406
      M28_Fxna_like; M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1

    2. NM_001362131.1 → NP_001349060.1  endoplasmic reticulum metallopeptidase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114578
      Conserved Domains (1) summary
      cd03875
      Location:99 → 406
      M28_Fxna_like; M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      29587276..29625815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UVK0.2 GenPept UniProtKB/Swiss-Prot:Q3UVK0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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