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    D16Ertd472e DNA segment, Chr 16, ERATO Doi 472, expressed [ Mus musculus (house mouse) ]

    Gene ID: 67102, updated on 21-Apr-2024

    Summary

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    Official Symbol
    D16Ertd472eprovided by MGI
    Official Full Name
    DNA segment, Chr 16, ERATO Doi 472, expressedprovided by MGI
    Primary source
    MGI:MGI:1196400
    See related
    Ensembl:ENSMUSG00000022864 AllianceGenome:MGI:1196400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eurl; 1700010I10Rik; 2310009O17Rik; E330003K22Rik
    Summary
    Involved in cerebral cortex neuron differentiation and positive regulation of dendritic spine development. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human C21orf91 (chromosome 21 open reading frame 91). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 5.2), testis adult (RPKM 4.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 C3.1; 16 45.36 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (78337224..78373576, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (78540336..78576688, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene BTG anti-proliferation factor 3 Neighboring gene predicted gene, 25038 Neighboring gene STARR-positive B cell enhancer ABC_E5553 Neighboring gene STARR-seq mESC enhancer starr_41307 Neighboring gene STARR-seq mESC enhancer starr_41309 Neighboring gene STARR-positive B cell enhancer ABC_E9935 Neighboring gene STARR-seq mESC enhancer starr_41310 Neighboring gene RIKEN cDNA 4930478L05 gene Neighboring gene STARR-positive B cell enhancer ABC_E4183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:78560476-78560629 Neighboring gene STARR-positive B cell enhancer mm9_chr16:78564961-78565261 Neighboring gene STARR-positive B cell enhancer ABC_E3169 Neighboring gene STARR-seq mESC enhancer starr_41311 Neighboring gene predicted gene, 24861 Neighboring gene RIKEN cDNA 4930570E03 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome. Li SS, et al. Sci Rep, 2016 Jul 11. PMID 27404227, Free PMC Article
    2. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    3. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854
    4. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebral cortex neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein EURL homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252438.1 → NP_001239367.1  protein EURL homolog

      See identical proteins and their annotated locations for NP_001239367.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC098883, AK009258
      Consensus CDS
      CCDS28278.1
      UniProtKB/Swiss-Prot
      Q9D7G4
      UniProtKB/TrEMBL
      Q8VE27
      Related
      ENSMUSP00000156198.2, ENSMUST00000232052.2
      Conserved Domains (1) summary
      pfam06937
      Location:1 → 284
      EURL; EURL protein

    2. NM_001252439.1 → NP_001239368.1  protein EURL homolog

      See identical proteins and their annotated locations for NP_001239368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC098883, AK005829, AW536354
      Consensus CDS
      CCDS28278.1
      UniProtKB/Swiss-Prot
      Q9D7G4
      UniProtKB/TrEMBL
      Q8VE27
      Related
      ENSMUSP00000109856.2, ENSMUST00000114218.2
      Conserved Domains (1) summary
      pfam06937
      Location:1 → 284
      EURL; EURL protein

    3. NM_001252440.1 → NP_001239369.1  protein EURL homolog

      See identical proteins and their annotated locations for NP_001239369.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC098883
      Consensus CDS
      CCDS28278.1
      UniProtKB/Swiss-Prot
      Q9D7G4
      UniProtKB/TrEMBL
      Q8VE27
      Related
      ENSMUSP00000109858.2, ENSMUST00000114220.9
      Conserved Domains (1) summary
      pfam06937
      Location:1 → 284
      EURL; EURL protein

    4. NM_025967.4 → NP_080243.3  protein EURL homolog

      See identical proteins and their annotated locations for NP_080243.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC098883, AK044670, CN662712
      Consensus CDS
      CCDS28278.1
      UniProtKB/Swiss-Prot
      Q9D7G4
      UniProtKB/TrEMBL
      Q8VE27
      Related
      ENSMUSP00000109857.2, ENSMUST00000114219.8
      Conserved Domains (1) summary
      pfam06937
      Location:1 → 284
      EURL; EURL protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      78337224..78373576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7G4.1 GenPept UniProtKB/Swiss-Prot:Q9D7G4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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