ADGRE2 adhesion G protein-coupled receptor E2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADGRE2provided by HGNC
Official Full Name: adhesion G protein-coupled receptor E2provided by HGNC
Primary source: HGNC:HGNC:3337
See related: Ensembl:ENSG00000127507 MIM:606100; AllianceGenome:HGNC:3337
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VBU; CD97; EMR2; CD312
Summary: This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Expression: Broad expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 16 other tissues See more
Orthologs: all
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Genomic context

Location:: 19p13.12

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (14724171..14778560, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (14850478..14906112, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (14843204..14889372, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Posttraumatic Increase in the Adhesion of GPCR EMR2/ADGRE2 to Circulating Neutrophils Is Not Related to Injury Severity.
Title: The Posttraumatic Increase in the Adhesion of GPCR EMR2/ADGRE2 to Circulating Neutrophils Is Not Related to Injury Severity.
Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes.
Title: Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes.
Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2.
Title: Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2.
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.
Title: Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.
G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody.
Title: G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody.
EMR2 stimulates tumor angiogenesis through RGD motif-dependent mechanism.EMR2 promotes tumor angiogenesis by overexpressing MMP-9.
Title: The role of the RGD motif in CD97/ADGRE5-and EMR2/ADGRE2-modulated tumor angiogenesis.
The ADGRE2 mutation causing familiar vibratory angioedema is not responsible for the frequent nonfamilial form.
Title: Ordinary vibratory angioedema is not generally associated with ADGRE2 mutation.
Results show that the membrane-associated EMR2-NTF displays a distinct N-glycosylation pattern. Moreover, its membrane-association ability is found to be regulated by site-specific N-glycosylation in the GAIN domain. The membrane-association of EMR2-NTF takes place in post-ER compartments and identify a unique amphipathic alpha-helix at the GAIN sub-domain A as a putative in-plane membrane anchor.
Title: Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation.
miR-99a reveals two novel targets E2F2 and EMR2 that play a key role in lung tumourigenesis. By inhibiting E2F2 and EMR2, miR-99a represses in vivo the transition of epithelial cells through an EMT process concomitantly with the inhibition of stemness features and consequently decreasing the CSC population.
Title: miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.
EMR2 expression levels correlated with CTP scores and increased further in cirrhotic patients with infections. These high EMR2-expressed neutrophils had activated phenotype but with deranged functions. Higher levels of these EMR2-expressed neutrophils correlated with infectious complications and predict mortality.
Title: Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Vibratory urticaria MedGen: C0157743 OMIM: 125630 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

EMR2_1829 (e-PCR)
- UniSTS:280654

RH75658 (e-PCR)
- UniSTS:92308

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables chondroitin sulfate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in granulocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in leading edge membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor E2

Names: CD97 antigen; EGF-like module-containing mucin-like hormone receptor-like 2; Leukocyte antigen CD97; egf-like module containing, mucin-like, hormone receptor-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047146.1 RefSeqGene

Range

4982..51150

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001271052.1 → NP_001257981.1 adhesion G protein-coupled receptor E2 isoform h precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (h) is shorter than isoform a.

Source sequence(s)

AC005327, AC090427, AK298700, BC127004, CN480316

Consensus CDS

CCDS59361.1

UniProtKB/TrEMBL

A0JNV7

Related

ENSP00000376692.3, ENST00000392965.7

Conserved Domains (4) summary

cd00054
Location:119 → 154

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd15439
Location:475 → 737

7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam07645
Location:212 → 243

EGF_CA; Calcium-binding EGF domain

pfam12662
Location:186 → 215

cEGF; Complement Clr-like EGF-like
NM_013447.4 → NP_038475.2 adhesion G protein-coupled receptor E2 isoform a precursor

See identical proteins and their annotated locations for NP_038475.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC005327, AC090427, AK298700, BC127004, BG721006, CN480316

Consensus CDS

CCDS32935.1

UniProtKB/Swiss-Prot

B4DQ96, E7ESD7, E9PBR1, E9PEL6, E9PFQ5, E9PG91, Q8NG96, Q9UHX3, Q9Y4B1

UniProtKB/TrEMBL

A0JNV7

Related

ENSP00000319883.3, ENST00000315576.8

Conserved Domains (4) summary

smart00303
Location:479 → 529

GPS; G-protein-coupled receptor proteolytic site domain

cd00054
Location:119 → 154

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:163 → 210

EGF_CA; Calcium-binding EGF domain

cl21561
Location:533 → 774

7tm_4; Olfactory receptor
NM_152916.2 → NP_690880.1 adhesion G protein-coupled receptor E2 isoform b precursor

Status: REVIEWED

Source sequence(s)

AC005327, AC090427

Consensus CDS

CCDS32934.1

UniProtKB/TrEMBL

A0JNV7

Related

ENSP00000470725.1, ENST00000594294.5
NM_152917.2 → NP_690881.1 adhesion G protein-coupled receptor E2 isoform c precursor

Status: REVIEWED

Source sequence(s)

AC005327, AC090427

Consensus CDS

CCDS32933.1

UniProtKB/TrEMBL

A0JNV7

Related

ENSP00000472735.1, ENST00000594076.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

14724171..14778560 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047438720.1 → XP_047294676.1 adhesion G protein-coupled receptor E2 isoform X3
XM_047438731.1 → XP_047294687.1 adhesion G protein-coupled receptor E2 isoform X17
XM_047438728.1 → XP_047294684.1 adhesion G protein-coupled receptor E2 isoform X13
XM_047438725.1 → XP_047294681.1 adhesion G protein-coupled receptor E2 isoform X11
XM_047438729.1 → XP_047294685.1 adhesion G protein-coupled receptor E2 isoform X14
XM_047438733.1 → XP_047294689.1 adhesion G protein-coupled receptor E2 isoform X19
XM_047438732.1 → XP_047294688.1 adhesion G protein-coupled receptor E2 isoform X18
XM_047438723.1 → XP_047294679.1 adhesion G protein-coupled receptor E2 isoform X8
XM_047438730.1 → XP_047294686.1 adhesion G protein-coupled receptor E2 isoform X16
XM_047438724.1 → XP_047294680.1 adhesion G protein-coupled receptor E2 isoform X9
XM_047438721.1 → XP_047294677.1 adhesion G protein-coupled receptor E2 isoform X4

Related

ENSP00000472280.2, ENST00000596991.6
XM_017026726.2 → XP_016882215.1 adhesion G protein-coupled receptor E2 isoform X5

UniProtKB/TrEMBL

A0JNV7
XM_011527951.4 → XP_011526253.1 adhesion G protein-coupled receptor E2 isoform X6

UniProtKB/TrEMBL

A0JNV7

Conserved Domains (4) summary

smart00303
Location:430 → 480

GPS; G-protein-coupled receptor proteolytic site domain

cd00054
Location:119 → 154

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:163 → 197

EGF_CA; Calcium-binding EGF domain

cl21561
Location:484 → 725

7tm_4; Olfactory receptor
XM_011527949.3 → XP_011526251.1 adhesion G protein-coupled receptor E2 isoform X2

UniProtKB/TrEMBL

Q53GP0

Related

ENSP00000471297.1, ENST00000601345.5

Conserved Domains (4) summary

smart00303
Location:468 → 518

GPS; G-protein-coupled receptor proteolytic site domain

cd00054
Location:119 → 154

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:163 → 210

EGF_CA; Calcium-binding EGF domain

cl21561
Location:522 → 763

7tm_4; Olfactory receptor
XM_011527948.3 → XP_011526250.1 adhesion G protein-coupled receptor E2 isoform X1

UniProtKB/TrEMBL

A0JNV7

Conserved Domains (4) summary

smart00303
Location:479 → 529

GPS; G-protein-coupled receptor proteolytic site domain

cd00054
Location:119 → 154

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:163 → 210

EGF_CA; Calcium-binding EGF domain

cl21561
Location:533 → 774

7tm_4; Olfactory receptor
XM_011527953.3 → XP_011526255.1 adhesion G protein-coupled receptor E2 isoform X10

UniProtKB/TrEMBL

A0JNV7

Related

ENSP00000469277.1, ENST00000595839.5

Conserved Domains (3) summary

smart00303
Location:386 → 436

GPS; G-protein-coupled receptor proteolytic site domain

pfam07645
Location:119 → 153

EGF_CA; Calcium-binding EGF domain

cl21561
Location:440 → 681

7tm_4; Olfactory receptor
XM_017026727.2 → XP_016882216.1 adhesion G protein-coupled receptor E2 isoform X15

UniProtKB/TrEMBL

Q53GP0
XM_047438727.1 → XP_047294683.1 adhesion G protein-coupled receptor E2 isoform X12
XM_011527952.4 → XP_011526254.1 adhesion G protein-coupled receptor E2 isoform X7

UniProtKB/TrEMBL

A0JNV7

Conserved Domains (3) summary

cd00054
Location:119 → 154

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:163 → 210

EGF_CA; Calcium-binding EGF domain

cl21561
Location:475 → 716

7tm_4; Olfactory receptor
XM_011527954.4 → XP_011526256.1 adhesion G protein-coupled receptor E2 isoform X20

UniProtKB/TrEMBL

A0JNV7

Conserved Domains (4) summary

smart00303
Location:366 → 416

GPS; G-protein-coupled receptor proteolytic site domain

cd00054
Location:6 → 41

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:50 → 97

EGF_CA; Calcium-binding EGF domain

cl21561
Location:420 → 661

7tm_4; Olfactory receptor
XM_011527955.3 → XP_011526257.1 adhesion G protein-coupled receptor E2 isoform X21

Conserved Domains (3) summary

smart00303
Location:280 → 330

GPS; G-protein-coupled receptor proteolytic site domain

pfam07645
Location:13 → 47

EGF_CA; Calcium-binding EGF domain

cl21561
Location:334 → 575

7tm_4; Olfactory receptor
XM_047438736.1 → XP_047294692.1 adhesion G protein-coupled receptor E2 isoform X24

UniProtKB/TrEMBL

B4DWB8, E9PEL8

Related

ENSP00000376689.3, ENST00000392962.3
XM_047438735.1 → XP_047294691.1 adhesion G protein-coupled receptor E2 isoform X23
XM_047438734.1 → XP_047294690.1 adhesion G protein-coupled receptor E2 isoform X22

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

14850478..14906112 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320779.1 → XP_054176754.1 adhesion G protein-coupled receptor E2 isoform X26
XM_054320793.1 → XP_054176768.1 adhesion G protein-coupled receptor E2 isoform X17
XM_054320783.1 → XP_054176758.1 adhesion G protein-coupled receptor E2 isoform X28
XM_054320787.1 → XP_054176762.1 adhesion G protein-coupled receptor E2 isoform X29
XM_054320778.1 → XP_054176753.1 adhesion G protein-coupled receptor E2 isoform X25
XM_054320780.1 → XP_054176755.1 adhesion G protein-coupled receptor E2 isoform X27
XM_054320789.1 → XP_054176764.1 adhesion G protein-coupled receptor E2 isoform X13
XM_054320790.1 → XP_054176765.1 adhesion G protein-coupled receptor E2 isoform X14
XM_054320795.1 → XP_054176770.1 adhesion G protein-coupled receptor E2 isoform X19
XM_054320794.1 → XP_054176769.1 adhesion G protein-coupled receptor E2 isoform X18
XM_054320784.1 → XP_054176759.1 adhesion G protein-coupled receptor E2 isoform X8
XM_054320792.1 → XP_054176767.1 adhesion G protein-coupled receptor E2 isoform X16
XM_054320785.1 → XP_054176760.1 adhesion G protein-coupled receptor E2 isoform X9
XM_054320786.1 → XP_054176761.1 adhesion G protein-coupled receptor E2 isoform X10
XM_054320781.1 → XP_054176756.1 adhesion G protein-coupled receptor E2 isoform X5
XM_054320777.1 → XP_054176752.1 adhesion G protein-coupled receptor E2 isoform X2
XM_054320797.1 → XP_054176772.1 adhesion G protein-coupled receptor E2 isoform X21
XM_054320782.1 → XP_054176757.1 adhesion G protein-coupled receptor E2 isoform X7
XM_054320791.1 → XP_054176766.1 adhesion G protein-coupled receptor E2 isoform X15
XM_054320788.1 → XP_054176763.1 adhesion G protein-coupled receptor E2 isoform X12
XM_054320796.1 → XP_054176771.1 adhesion G protein-coupled receptor E2 isoform X20
XM_054320799.1 → XP_054176774.1 adhesion G protein-coupled receptor E2 isoform X24
XM_054320798.1 → XP_054176773.1 adhesion G protein-coupled receptor E2 isoform X22

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_152918.1: Suppressed sequence

Description

NM_152918.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_152919.1: Suppressed sequence

Description

NM_152919.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_152920.1: Suppressed sequence

Description

NM_152920.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_152921.1: Suppressed sequence

Description

NM_152921.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.