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    SIK2 salt inducible kinase 2 [ Homo sapiens (human) ]

    Gene ID: 23235, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SIK2provided by HGNC
    Official Full Name
    salt inducible kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:21680
    See related
    Ensembl:ENSG00000170145 MIM:608973; AllianceGenome:HGNC:21680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    QIK; SIK-2; SNF1LK2; LOH11CR1I
    Summary
    Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 24.2), brain (RPKM 10.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SIK2 in Genome Data Viewer
    Location:
    11q23.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (111602449..111730855)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (111612584..111741007)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111473173..111601579)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111410548-111411227 Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:111424938-111426137 Neighboring gene Sharpr-MPRA regulatory region 3081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:111435687-111436190 Neighboring gene layilin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3899 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111563346-111563859 Neighboring gene RN7SK pseudogene 273 Neighboring gene protein phosphatase 2 scaffold subunit Abeta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111594031-111594566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111603371-111604187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:111605768-111606404 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:111636139-111637042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3900 Neighboring gene uncharacterized LOC124902756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3901 Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:111685391-111686590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111709725-111710226 Neighboring gene G protein subunit gamma 5 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Salt-inducible kinase 2 functions as a tumor suppressor in hepatocellular carcinoma. Li Y, et al. Environ Toxicol, 2021 Dec. PMID 34491613
    2. SIK2 enhances synthesis of fatty acid and cholesterol in ovarian cancer cells and tumor growth through PI3K/Akt signaling pathway. Zhao J, et al. Cell Death Dis, 2020 Jan 13. PMID 31932581, Free PMC Article
    3. SIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival. Maxfield KE, et al. Mol Cell Biol, 2016 Dec 15. PMID 27697861, Free PMC Article
    4. Activation of salt-inducible kinase 2 promotes the viability of peritoneal mesothelial cells exposed to stress of peritoneal dialysis. Wang HH, et al. Cell Death Dis, 2016 Jul 21. PMID 27441650, Free PMC Article
    5. Salt-inducible kinase 2 regulates mitotic progression and transcription in prostate cancer. Bon H, et al. Mol Cancer Res, 2015 Apr. PMID 25548099, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SIK2-positive tumor epithelial cells in breast cancer maybe potential anti-cancer messengers: A systematic analysis from a single-cell perspective.
      Title: SIK2-positive tumor epithelial cells in breast cancer maybe potential anti-cancer messengers: A systematic analysis from a single-cell perspective.
    2. LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.
      Title: LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.
    3. Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes.
      Title: Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes.
    4. Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
      Title: Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
    5. SIK2 protects against renal tubular injury and the progression of diabetic kidney disease.
      Title: SIK2 protects against renal tubular injury and the progression of diabetic kidney disease.
    6. SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
      Title: SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
    7. SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/beta-catenin signaling.
      Title: SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/β-catenin signaling.
    8. SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells.
      Title: SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells.
    9. LINC00662 facilitates osteosarcoma progression via sponging miR-103a-3p and regulating SIK2 expression.
      Title: LINC00662 facilitates osteosarcoma progression via sponging miR-103a-3p and regulating SIK2 expression.
    10. Role of saltinducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells.
      Title: Role of salt‑inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0781, DKFZp434K1115

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase SIK2
    Names
    SNF1-like kinase 2
    qin-induced kinase
    salt-inducible protein kinase 2
    salt-inducible serine/threonine kinase 2
    serine/threonine-protein kinase SNF1-like kinase 2
    NP_056006.1
    XP_016872906.1
    XP_054224167.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015191.3 → NP_056006.1  serine/threonine-protein kinase SIK2

      See identical proteins and their annotated locations for NP_056006.1

      Status: VALIDATED

      Source sequence(s)
      AP000925
      Consensus CDS
      CCDS8347.1
      UniProtKB/Swiss-Prot
      A8K5B8, B0YJ94, O94878, Q17RV0, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8, Q9H0K1
      Related
      ENSP00000305976.3, ENST00000304987.4
      Conserved Domains (2) summary
      cd14409
      Location:297 → 341
      UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
      cd14071
      Location:19 → 271
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      111602449..111730855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017417.2 → XP_016872906.1  serine/threonine-protein kinase SIK2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      111612584..111741007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368192.1 → XP_054224167.1  serine/threonine-protein kinase SIK2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H0K1.1 GenPept UniProtKB/Swiss-Prot:Q9H0K1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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