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    MPRIP myosin phosphatase Rho interacting protein [ Homo sapiens (human) ]

    Gene ID: 23164, updated on 3-Apr-2024

    Summary

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    Official Symbol
    MPRIPprovided by HGNC
    Official Full Name
    myosin phosphatase Rho interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:30321
    See related
    Ensembl:ENSG00000133030 MIM:612935; AllianceGenome:HGNC:30321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRIP; RIP3; M-RIP; RHOIP3; p116Rip
    Summary
    Enables cadherin binding activity. Predicted to be involved in actin filament organization. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in endometrium (RPKM 19.8), brain (RPKM 18.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    17p11.2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (17042457..17192643)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (16988540..17138696)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16945771..17095957)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16899244-16899806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11785 Neighboring gene long intergenic non-protein coding RNA 2090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16908048-16908576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16914402-16915394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16923086-16924033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16932678-16933252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11786 Neighboring gene uncharacterized LOC124903938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8233 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:16946458-16947657 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16959278-16959917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16975468-16975993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16975994-16976520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16991083-16991584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16999002-16999588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17011600-17012124 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17022544-17023069 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17029831-17030330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17030795-17031296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17031297-17031796 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17034927-17035431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17043984-17044574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17045275-17045817 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17045818-17046359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17070554-17071156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17074887-17075546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17075547-17076206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11790 Neighboring gene RNA, U6 small nuclear 767, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17088115-17088615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11791 Neighboring gene RNA, 7SL, cytoplasmic 775, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17094445-17095112 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17095113-17095778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17109841-17110680 Neighboring gene phospholipase D family member 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17132411-17132910 Neighboring gene folliculin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription. Balaban C, et al. Biomolecules, 2023 Feb 24. PMID 36979361, Free PMC Article
    2. The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus. Balaban C, et al. Cells, 2021 Apr 8. PMID 33918018, Free PMC Article
    3. M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. Surks HK, et al. J Biol Chem, 2005 Dec 30. PMID 16257966
    4. Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions. Sala-Valdés M, et al. J Cell Sci, 2012 Mar 1. PMID 22349701
    5. An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers. Vallenius T, et al. J Cell Sci, 2011 Feb 1. PMID 21242312

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation and apoptosis of non-small cell lung cancer cells].
      Title: [circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation and apoptosis of non-small cell lung cancer cells].
    2. PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription.
      Title: PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription.
    3. The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus.
      Title: The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus.
    4. The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.
      Title: The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.
    5. Our data identify M-RIP as a crucial local regulator of the Rho-Rac balance during chemotaxis and antigen recognition.
      Title: Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions.
    6. MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP and the inducible kinase NUAK2
      Title: An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.
    7. A functional analysis of JNK1 and M-RIP with RNA interference reveals a critical role for this cascade in the invasive behavior of cancer cells.
      Title: M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.
    8. p116Rip is an important regulatory component that controls the RhoA signaling pathway, thus regulating MLCP activity and myosin phosphorylation in cells
      Title: p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA.
    9. M-RIP-dependent targeting of myosin phosphatase to stress fibers has an important role in regulating myosin light chain phosphorylation state and morphology in human vascular smooth muscle cells
      Title: M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis for severe diabetic retinopathy.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0864

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in focal adhesion HDA PubMed 

    General protein information

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    Preferred Names
    myosin phosphatase Rho-interacting protein
    Names
    Rho interacting protein 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364716.4 → NP_001351645.2  myosin phosphatase Rho-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC055811, AC079111, AC104024
      Consensus CDS
      CCDS92265.1
      UniProtKB/TrEMBL
      A0A494BZV2
      Related
      ENSP00000498253.1, ENST00000651222.2
      Conserved Domains (6) summary
      PHA03307
      Location:303 → 502
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:2061 → 2362
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01236
      Location:16 → 151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:508 → 609
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:797 → 1159
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:1860 → 2168
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. NM_015134.4 → NP_055949.2  myosin phosphatase Rho-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_055949.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC055811, AC079111, AC104024, AK092287, BC009982, BC136479
      Consensus CDS
      CCDS42268.1
      UniProtKB/TrEMBL
      B9EGI2
      Related
      ENSP00000379156.4, ENST00000395811.9
      Conserved Domains (6) summary
      cd01236
      Location:16 → 151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:390 → 491
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:390 → 483
      PH; PH domain
      cd16269
      Location:760 → 771
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:738 → 980
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:679 → 788
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_201274.4 → NP_958431.2  myosin phosphatase Rho-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_958431.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC055811, AC079111, AC104024, AY296247, BC075847, BE048871
      Consensus CDS
      CCDS32578.1
      UniProtKB/Swiss-Prot
      Q3KQZ5, Q5FB94, Q6DHW2, Q6WCQ1, Q7Z5Y2, Q8N390, Q96G40
      UniProtKB/TrEMBL
      B9EGI2
      Related
      ENSP00000342379.4, ENST00000341712.8
      Conserved Domains (6) summary
      cd01236
      Location:16 → 151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:390 → 491
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:390 → 483
      PH; PH domain
      cd16269
      Location:760 → 771
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:738 → 980
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:679 → 788
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      17042457..17192643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523764.3 → XP_011522066.1  myosin phosphatase Rho-interacting protein isoform X2

      Conserved Domains (9) summary
      cd01236
      Location:48 → 183
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:540 → 641
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:540 → 633
      PH; PH domain
      pfam10473
      Location:1062 → 1190
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15619
      Location:885 → 1036
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      pfam16043
      Location:1048 → 1191
      DUF4795; Domain of unknown function (DUF4795)
      cl02488
      Location:2157 → 2314
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl12013
      Location:928 → 1117
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl19219
      Location:2098 → 2198
      DUF342; Protein of unknown function (DUF342)

    2. XM_011523766.3 → XP_011522068.2  myosin phosphatase Rho-interacting protein isoform X5

      UniProtKB/TrEMBL
      B9EGI2

    3. XM_047435685.1 → XP_047291641.1  myosin phosphatase Rho-interacting protein isoform X7

    4. XM_011523763.3 → XP_011522065.1  myosin phosphatase Rho-interacting protein isoform X1

      Conserved Domains (8) summary
      cd01236
      Location:48 → 183
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:502 → 603
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:502 → 595
      PH; PH domain
      pfam10473
      Location:1024 → 1152
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15619
      Location:847 → 998
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      pfam16043
      Location:1010 → 1153
      DUF4795; Domain of unknown function (DUF4795)
      cl03951
      Location:2080 → 2179
      CDC37_N; Cdc37 N terminal kinase binding
      cl12013
      Location:890 → 1079
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_047435684.1 → XP_047291640.1  myosin phosphatase Rho-interacting protein isoform X6

    6. XM_005256563.5 → XP_005256620.1  myosin phosphatase Rho-interacting protein isoform X3

      Conserved Domains (7) summary
      cd01236
      Location:48 → 183
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:422 → 523
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:422 → 515
      PH; PH domain
      pfam10473
      Location:944 → 1072
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15619
      Location:767 → 918
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cl03951
      Location:2000 → 2099
      CDC37_N; Cdc37 N terminal kinase binding
      cl12013
      Location:828 → 999
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_047435683.1 → XP_047291639.1  myosin phosphatase Rho-interacting protein isoform X4

    8. XM_047435686.1 → XP_047291642.1  myosin phosphatase Rho-interacting protein isoform X9

    9. XM_005256564.5 → XP_005256621.3  myosin phosphatase Rho-interacting protein isoform X8

      UniProtKB/TrEMBL
      B9EGI2
      Related
      ENSP00000462688.1, ENST00000584067.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      16988540..17138696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315583.1 → XP_054171558.1  myosin phosphatase Rho-interacting protein isoform X11

    2. XM_054315586.1 → XP_054171561.1  myosin phosphatase Rho-interacting protein isoform X14

    3. XM_054315588.1 → XP_054171563.1  myosin phosphatase Rho-interacting protein isoform X16

    4. XM_054315582.1 → XP_054171557.1  myosin phosphatase Rho-interacting protein isoform X10

    5. XM_054315587.1 → XP_054171562.1  myosin phosphatase Rho-interacting protein isoform X15

    6. XM_054315584.1 → XP_054171559.1  myosin phosphatase Rho-interacting protein isoform X12

    7. XM_054315585.1 → XP_054171560.1  myosin phosphatase Rho-interacting protein isoform X13

    8. XM_054315590.1 → XP_054171565.1  myosin phosphatase Rho-interacting protein isoform X18

    9. XM_054315589.1 → XP_054171564.1  myosin phosphatase Rho-interacting protein isoform X17

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6WCQ1.3 GenPept UniProtKB/Swiss-Prot:Q6WCQ1

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