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    Mmp23 matrix metallopeptidase 23 [ Mus musculus (house mouse) ]

    Gene ID: 26561, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Mmp23provided by MGI
    Official Full Name
    matrix metallopeptidase 23provided by MGI
    Primary source
    MGI:MGI:1347361
    See related
    Ensembl:ENSMUSG00000029061 AllianceGenome:MGI:1347361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CA-MMP
    Summary
    This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein contains an N-terminal cysteine array and a novel immunoglobulin-fold domain at the C-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, Feb 2016]
    Expression
    Broad expression in ovary adult (RPKM 36.0), bladder adult (RPKM 24.1) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mmp23 in Genome Data Viewer
    Location:
    4 E2; 4 86.85 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155735111..155738982, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155650655..155654539, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene cyclin dependent kinase 11B Neighboring gene STARR-seq mESC enhancer starr_12269 Neighboring gene mindbomb E3 ubiquitin protein ligase 2 Neighboring gene STARR-seq mESC enhancer starr_12270 Neighboring gene STARR-seq mESC enhancer starr_12271 Neighboring gene STARR-positive B cell enhancer ABC_E6297 Neighboring gene fibronectin type III domain containing 10 Neighboring gene STARR-seq mESC enhancer starr_12272 Neighboring gene Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) Neighboring gene predicted gene, 22573

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CA-MMP: a matrix metalloproteinase with a novel cysteine array, but without the classic cysteine switch. Pei D. FEBS Lett, 1999 Aug 27. PMID 10471791
    2. Matrix metalloproteinases in tumor invasion. Johansson N, et al. Cell Mol Life Sci, 2000 Jan 20. PMID 10949577
    3. Functional interactions between matrix metalloproteinases and glycosaminoglycans. Tocchi A, et al. FEBS J, 2013 May. PMID 23421805
    4. Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Perez SE, et al. Diabetes, 2005 Mar. PMID 15734845, Free PMC Article
    5. Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. Garcia-Ortiz JE, et al. BMC Dev Biol, 2009 Jun 18. PMID 19538736, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130334, MGC130335

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    matrix metalloproteinase-23
    Names
    CAMP metalloproteinase
    cysteine array matrix metalloproteinase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320235.2 → NP_001307164.1  matrix metalloproteinase-23 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL627405
      UniProtKB/Swiss-Prot
      O88676
      Conserved Domains (4) summary
      smart00254
      Location:242 → 276
      ShKT; ShK toxin domain
      cd04278
      Location:88 → 241
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:88 → 241
      Peptidase_M10; Matrixin
      cl11960
      Location:300 → 360
      Ig; Immunoglobulin domain

    2. NM_001424937.1 → NP_001411866.1  matrix metalloproteinase-23 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL627405

    3. NM_001424938.1 → NP_001411867.1  matrix metalloproteinase-23 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL627405

    4. NM_011985.4 → NP_036115.1  matrix metalloproteinase-23 isoform 1 precursor

      See identical proteins and their annotated locations for NP_036115.1

      Status: REVIEWED

      Source sequence(s)
      AL627405
      Consensus CDS
      CCDS19034.1
      UniProtKB/Swiss-Prot
      O88676, Q3KNC0
      Related
      ENSMUSP00000030937.2, ENSMUST00000030937.2
      Conserved Domains (3) summary
      smart00254
      Location:256 → 290
      ShKT; ShK toxin domain
      cd04278
      Location:88 → 255
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cl11960
      Location:314 → 374
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155735111..155738982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538882.4 → XP_006538945.1  matrix metalloproteinase-23 isoform X3

      See identical proteins and their annotated locations for XP_006538945.1

      UniProtKB/Swiss-Prot
      O88676, Q3KNC0
      Conserved Domains (3) summary
      smart00254
      Location:256 → 290
      ShKT; ShK toxin domain
      cd04278
      Location:88 → 255
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cl11960
      Location:314 → 374
      Ig; Immunoglobulin domain

    2. XM_006538881.4 → XP_006538944.1  matrix metalloproteinase-23 isoform X2

      Conserved Domains (3) summary
      smart00254
      Location:271 → 305
      ShKT; ShK toxin domain
      cd04278
      Location:88 → 270
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cl11960
      Location:329 → 389
      Ig; Immunoglobulin domain

    3. XM_006538880.5 → XP_006538943.1  matrix metalloproteinase-23 isoform X1

      See identical proteins and their annotated locations for XP_006538943.1

      Conserved Domains (3) summary
      smart00254
      Location:285 → 319
      ShKT; ShK toxin domain
      cd04278
      Location:88 → 284
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cl11960
      Location:343 → 403
      Ig; Immunoglobulin domain

    4. XM_006538879.4 → XP_006538942.1  matrix metalloproteinase-23 isoform X1

      See identical proteins and their annotated locations for XP_006538942.1

      Conserved Domains (3) summary
      smart00254
      Location:285 → 319
      ShKT; ShK toxin domain
      cd04278
      Location:88 → 284
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cl11960
      Location:343 → 403
      Ig; Immunoglobulin domain

    5. XM_036164136.1 → XP_036020029.1  matrix metalloproteinase-23 isoform X3

      UniProtKB/Swiss-Prot
      O88676, Q3KNC0
      Conserved Domains (3) summary
      smart00254
      Location:256 → 290
      ShKT; ShK toxin domain
      cd04278
      Location:88 → 255
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cl11960
      Location:314 → 374
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88676.1 GenPept UniProtKB/Swiss-Prot:O88676

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