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    Ccnh cyclin H [ Mus musculus (house mouse) ]

    Gene ID: 66671, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ccnhprovided by MGI
    Official Full Name
    cyclin Hprovided by MGI
    Primary source
    MGI:MGI:1913921
    See related
    Ensembl:ENSMUSG00000021548 AllianceGenome:MGI:1913921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330408H09Rik
    Summary
    Enables kinase activity. Predicted to be involved in several processes, including protein stabilization; regulation of cyclin-dependent protein serine/threonine kinase activity; and transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in cerebellum; cranium; and limb mesenchyme. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.7), CNS E18 (RPKM 11.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 C3; 13 45.05 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (85337504..85361850)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (85189377..85213731)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35175 Neighboring gene STARR-seq mESC enhancer starr_35176 Neighboring gene smoothened homolog pseudogene Neighboring gene NADH-ubiquinone oxidoreductase chain 5-like Neighboring gene STARR-seq mESC enhancer starr_35177 Neighboring gene STARR-seq mESC enhancer starr_35178 Neighboring gene RAS p21 protein activator 1 Neighboring gene STARR-seq mESC enhancer starr_35180 Neighboring gene STARR-seq mESC enhancer starr_35181 Neighboring gene STARR-positive B cell enhancer mm9_chr13:85569683-85569983 Neighboring gene STARR-seq mESC enhancer starr_35182 Neighboring gene STARR-seq mESC enhancer starr_35183 Neighboring gene STARR-seq mESC enhancer starr_35184 Neighboring gene high mobility group box 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis. Guo Z, et al. Cancer Res, 2001 Dec 1. PMID 11731416
    2. Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos. Patel SA, et al. J Biol Chem, 2010 May 14. PMID 20231280, Free PMC Article
    3. Meiotic expression of the cyclin H/Cdk7 complex in male germ cells of the mouse. Kim JM, et al. Biol Reprod, 2001 May. PMID 11319144
    4. Functional interaction of Puralpha with the Cdk2 moiety of cyclin A/Cdk2. Liu H, et al. Biochem Biophys Res Commun, 2005 Mar 25. PMID 15707957
    5. Mouse development and cell proliferation in the absence of D-cyclins. Kozar K, et al. Cell, 2004 Aug 20. PMID 15315760

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CAK-ERCC2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cyclin-dependent protein kinase activating kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIK complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347587.1 → NP_001334516.1  cyclin-H isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK078059, BM899601, BQ032543, BY767531
      Consensus CDS
      CCDS84047.1
      UniProtKB/TrEMBL
      E9PWD3, Q3UUW5
      Related
      ENSMUSP00000129349.2, ENSMUST00000163600.8

    2. NM_001347588.1 → NP_001334517.1  cyclin-H isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AK078059, BM899601, BY767531
      UniProtKB/Swiss-Prot
      Q61458

    3. NM_023243.6 → NP_075732.1  cyclin-H isoform a

      See identical proteins and their annotated locations for NP_075732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK078059, BM899601, BY767531
      Consensus CDS
      CCDS26666.1
      UniProtKB/Swiss-Prot
      Q61458, Q9CVJ0, Q9JHV7
      UniProtKB/TrEMBL
      Q3UUW5
      Related
      ENSMUSP00000022030.5, ENSMUST00000022030.11
      Conserved Domains (3) summary
      TIGR00569
      Location:2 → 308
      ccl1; cyclin ccl1
      smart00385
      Location:62 → 152
      CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
      pfam16899
      Location:162 → 262
      Cyclin_C_2; Cyclin C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      85337504..85361850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517325.4 → XP_006517388.1  cyclin-H isoform X1

      Conserved Domains (1) summary
      TIGR00569
      Location:2 → 213
      ccl1; cyclin ccl1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61458.2 GenPept UniProtKB/Swiss-Prot:Q61458

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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