Slc25a30 solute carrier family 25, member 30 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a30provided by MGI
Official Full Name: solute carrier family 25, member 30provided by MGI
Primary source: MGI:MGI:1914804
See related: Ensembl:ENSMUSG00000022003 AllianceGenome:MGI:1914804
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KMCP1; 4933433D23Rik
Summary: Predicted to enable C4-dicarboxylate transmembrane transporter activity; antiporter activity; and sulfur compound transmembrane transporter activity. Predicted to be involved in anion transport. Located in mitochondrion. Is expressed in adrenal medulla; ganglia; medulla oblongata basal plate mantle layer; and metanephros. Orthologous to human SLC25A30 (solute carrier family 25 member 30). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 6.9), ovary adult (RPKM 6.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 40.29 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (75994986..76024477, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (75757534..75787037, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KMCP1 is involved in situations in which mitochondrial metabolism is increased, in particular when the cellular redox balance tends toward a pro-oxidant status
Title: A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW319655 (e-PCR)
- UniSTS:180705

Slc25a30 (e-PCR), detects polymorphism
- UniSTS:547324

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables solute:inorganic anion antiporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in inorganic anion transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kidney mitochondrial carrier protein 1

Names: VH186.2-D-J-C mu

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026232.3 → NP_080508.1 kidney mitochondrial carrier protein 1

See identical proteins and their annotated locations for NP_080508.1

Status: PROVISIONAL

Source sequence(s)

AC122285

Consensus CDS

CCDS27281.1

UniProtKB/Swiss-Prot

Q3UAD0, Q9CR58

Related

ENSMUSP00000022580.7, ENSMUST00000022580.8

Conserved Domains (2) summary

PTZ00169
Location:9 → 289

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:199 → 289

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

75994986..76024477 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519456.5 → XP_006519519.1 kidney mitochondrial carrier protein 1 isoform X2

UniProtKB/TrEMBL

Q8R206

Conserved Domains (1) summary

pfam00153
Location:105 → 191

Mito_carr; Mitochondrial carrier protein
XM_006519455.5 → XP_006519518.1 kidney mitochondrial carrier protein 1 isoform X1

Conserved Domains (1) summary

pfam00153
Location:105 → 191

Mito_carr; Mitochondrial carrier protein