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    Car10 carbonic anhydrase 10 [ Mus musculus (house mouse) ]

    Gene ID: 72605, updated on 10-Jun-2024

    Summary

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    Official Symbol
    Car10provided by MGI
    Official Full Name
    carbonic anhydrase 10provided by MGI
    Primary source
    MGI:MGI:1919855
    See related
    Ensembl:ENSMUSG00000056158 AllianceGenome:MGI:1919855
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ca10; 2700029L05Rik
    Summary
    Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Is expressed in several structures, including cardiovascular system; central nervous system; foregut; integumental system; and respiratory system. Orthologous to human CA10 (carbonic anhydrase 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 15.9), cortex adult (RPKM 14.4) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Car10 in Genome Data Viewer
    Location:
    11 D; 11 58.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (92988807..93492577)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (93096805..93601751)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30433 Neighboring gene YKT6 homolog pseudogene Neighboring gene predicted gene, 25113 Neighboring gene STARR-seq mESC enhancer starr_30434 Neighboring gene STARR-seq mESC enhancer starr_30435 Neighboring gene predicted gene, 35002 Neighboring gene predicted gene, 24856 Neighboring gene STARR-seq mESC enhancer starr_30437 Neighboring gene STARR-seq mESC enhancer starr_30439 Neighboring gene 60S ribosomal protein L26-like Neighboring gene predicted gene 11502

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand. Sterky FH, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28154140, Free PMC Article
    2. cDNA cloning and developmental expression of murine carbonic anhydrase-related proteins VIII, X, and XI. Taniuchi K, et al. Brain Res Mol Brain Res, 2002 Dec 30. PMID 12531530
    3. Mapping blood pressure loci in (A/J x B6)F2 mice. Woo DD, et al. Physiol Genomics, 2003 Nov 11. PMID 14612590
    4. A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development. Wu L, et al. Dev Dyn, 2013 Mar. PMID 23233153
    5. Nucleome Dynamics during Retinal Development. Norrie JL, et al. Neuron, 2019 Nov 6. PMID 31493975, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CA10 directly binds in a cis configuration to a conserved membrane-proximal, extracellular sequence of alpha- and beta-neurexins.
      Title: Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand.
    2. Results describe the tissue distribution of carbonic anhydrase-related proteins VIII, X, and XI and their developmental expression in the murine embryonic brain.
      Title: cDNA cloning and developmental expression of murine carbonic anhydrase-related proteins VIII, X, and XI.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase-related protein 10
    Names
    CA-RP X
    CARP X
    carbonic anhydrase-related protein X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361707.1 → NP_001348636.1  carbonic anhydrase-related protein 10 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AL683819, AL713960, AL731728, AL731849, AL954830
      Consensus CDS
      CCDS25244.1
      UniProtKB/Swiss-Prot
      P61215
      UniProtKB/TrEMBL
      Q3V1V7, Q6NZJ2
      Related
      ENSMUSP00000103490.3, ENSMUST00000107858.9
      Conserved Domains (1) summary
      cd03121
      Location:46 → 302
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

    2. NM_001361708.1 → NP_001348637.1  carbonic anhydrase-related protein 10 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL683819, AL713960, AL731728, AL731849, AL954830
      Consensus CDS
      CCDS25244.1
      UniProtKB/Swiss-Prot
      P61215
      UniProtKB/TrEMBL
      Q3V1V7, Q6NZJ2
      Related
      ENSMUSP00000035585.7, ENSMUST00000042943.13
      Conserved Domains (1) summary
      cd03121
      Location:46 → 302
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

    3. NM_028296.3 → NP_082572.1  carbonic anhydrase-related protein 10 precursor

      See identical proteins and their annotated locations for NP_082572.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK036003, AK132222, CJ280653
      Consensus CDS
      CCDS25244.1
      UniProtKB/Swiss-Prot
      P61215
      UniProtKB/TrEMBL
      Q3V1V7, Q6NZJ2
      Related
      ENSMUSP00000103495.3, ENSMUST00000107863.4
      Conserved Domains (1) summary
      cd03121
      Location:46 → 302
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      92988807..93492577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246367.2 → XP_030102227.1  carbonic anhydrase-related protein 10 isoform X1

      UniProtKB/Swiss-Prot
      P61215
      UniProtKB/TrEMBL
      Q3V1V7, Q6NZJ2
      Conserved Domains (1) summary
      cd03121
      Location:46 → 302
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

    2. XM_030246368.2 → XP_030102228.1  carbonic anhydrase-related protein 10 isoform X1

      UniProtKB/Swiss-Prot
      P61215
      UniProtKB/TrEMBL
      Q3V1V7, Q6NZJ2
      Conserved Domains (1) summary
      cd03121
      Location:46 → 302
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61215.1 GenPept UniProtKB/Swiss-Prot:P61215

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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