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    Mrpl48 mitochondrial ribosomal protein L48 [ Mus musculus (house mouse) ]

    Gene ID: 52443, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mrpl48provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L48provided by MGI
    Primary source
    MGI:MGI:1289321
    See related
    Ensembl:ENSMUSG00000030706 AllianceGenome:MGI:1289321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L48mt; CGI-118; MRP-L48; D4Ertd786e; 1810030E20Rik; 2610028L11Rik
    Summary
    Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL48 (mitochondrial ribosomal protein L48). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 26.8), cerebellum adult (RPKM 24.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl48 in Genome Data Viewer
    Location:
    7 E2; 7 54.36 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100194986..100257508, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100545779..100608301, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107685672-107685781 Neighboring gene predicted gene, 39059 Neighboring gene cytochrome c oxidase assembly factor 4 Neighboring gene STARR-positive B cell enhancer ABC_E9294 Neighboring gene STARR-positive B cell enhancer ABC_E6573 Neighboring gene cytochrome c oxidase assembly protein 20B Neighboring gene STARR-positive B cell enhancer ABC_E1738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107756073-107756182 Neighboring gene RAB6A, member RAS oncogene family Neighboring gene pleckstrin homology domain containing, family B (evectins) member 1 Neighboring gene predicted gene, 53385 Neighboring gene predicted gene, 35082

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    2. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    3. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
    4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrial ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL48
    Names
    39S ribosomal protein L48, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198831.3 → NP_942128.2  large ribosomal subunit protein mL48 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding variant.
      Source sequence(s)
      AC117215
      Consensus CDS
      CCDS21502.2
      UniProtKB/Swiss-Prot
      Q4VA35, Q8JZS9
      UniProtKB/TrEMBL
      E9QPQ8
      Related
      ENSMUSP00000116090.2, ENSMUST00000150042.8
      Conserved Domains (2) summary
      smart00487
      Location:132 → 194
      DEXDc; DEAD-like helicases superfamily
      pfam00338
      Location:91 → 185
      Ribosomal_S10; Ribosomal protein S10p/S20e

    RNA

    1. NR_003559.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117215, AC124531

    2. NR_153424.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117215, AC124531

    3. NR_153425.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117215, AC124531

    4. NR_153426.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117215

    5. NR_153427.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117215

    6. NR_153428.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117215

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100194986..100257508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153237.1 → XP_036009130.1  large ribosomal subunit protein mL48 isoform X1

      UniProtKB/Swiss-Prot
      Q4VA35, Q8JZS9
      Conserved Domains (1) summary
      pfam00338
      Location:96 → 190
      Ribosomal_S10; Ribosomal protein S10p/S20e

    2. XM_036153238.1 → XP_036009131.1  large ribosomal subunit protein mL48 isoform X1

      UniProtKB/Swiss-Prot
      Q4VA35, Q8JZS9
      Conserved Domains (1) summary
      pfam00338
      Location:96 → 190
      Ribosomal_S10; Ribosomal protein S10p/S20e

    3. XM_036153236.1 → XP_036009129.1  large ribosomal subunit protein mL48 isoform X1

      UniProtKB/Swiss-Prot
      Q4VA35, Q8JZS9
      Conserved Domains (1) summary
      pfam00338
      Location:96 → 190
      Ribosomal_S10; Ribosomal protein S10p/S20e

    4. XM_006508021.5 → XP_006508084.1  large ribosomal subunit protein mL48 isoform X2

      UniProtKB/TrEMBL
      A0A140LHT6, A2VCS1
      Related
      ENSMUSP00000146539.2, ENSMUST00000146003.9
      Conserved Domains (1) summary
      pfam00338
      Location:1 → 87
      Ribosomal_S10; Ribosomal protein S10p/S20e
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZS9.1 GenPept UniProtKB/Swiss-Prot:Q8JZS9

    Gene LinkOut

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