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    Il20ra interleukin 20 receptor, alpha [ Mus musculus (house mouse) ]

    Gene ID: 237313, updated on 12-May-2024

    Summary

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    Official Symbol
    Il20raprovided by MGI
    Official Full Name
    interleukin 20 receptor, alphaprovided by MGI
    Primary source
    MGI:MGI:3605069
    See related
    Ensembl:ENSMUSG00000020007 AllianceGenome:MGI:3605069
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E230031K19
    Summary
    Enables interleukin-20 binding activity. Acts upstream of or within cytokine-mediated signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; and regulation of bone resorption. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in epididymis; eye; and ileum. Orthologous to human IL20RA (interleukin 20 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 A3; 10 8.76 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (19587421..19635801)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (19711673..19760053)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2317 Neighboring gene interferon gamma receptor 1 Neighboring gene interleukin 22 receptor, alpha 2 Neighboring gene STARR-seq mESC enhancer starr_25939 Neighboring gene predicted gene, 33332 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19411574-19411868 Neighboring gene predicted gene, 25256 Neighboring gene solute carrier family 35, member D3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models. Lu SW, et al. Nat Commun, 2020 Sep 14. PMID 32929072, Free PMC Article
    2. Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition. Wei CC, et al. Genes Immun, 2009 Apr. PMID 19078987
    3. Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation. Weng YH, et al. Front Immunol, 2019. PMID 31114590, Free PMC Article
    4. Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 mice astroglial cells and brain cortex following LPS stimulation. Abd Nikfarjam B, et al. Iran J Immunol, 2013 Jun. PMID 23811545
    5. Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury. Hsu YH, et al. PLoS One, 2013. PMID 23468852, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-20R1 and IL-20R2 are constitutively express in the brain.
      Title: Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 mice astroglial cells and brain cortex following LPS stimulation.
    2. mIL-20R1a functioned as an aggravating factor in promoting calcium deposition in kidney of mice.
      Title: Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-20 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-20 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-20 receptor subunit alpha
    Names
    IL-20 receptor subunit alpha
    IL-20R-alpha
    IL-20R1
    IL-20RA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172786.2 → NP_766374.1  interleukin-20 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_766374.1

      Status: PROVISIONAL

      Source sequence(s)
      AK054215
      Consensus CDS
      CCDS23718.1
      UniProtKB/Swiss-Prot
      Q6PHB0, Q8BW64
      Related
      ENSMUSP00000020185.4, ENSMUST00000020185.5
      Conserved Domains (2) summary
      pfam01108
      Location:29 → 126
      Tissue_fac; Tissue factor
      pfam09294
      Location:138 → 242
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      19587421..19635801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512726.1 → XP_006512789.1  interleukin-20 receptor subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006512789.1

      UniProtKB/Swiss-Prot
      Q6PHB0, Q8BW64
      Conserved Domains (2) summary
      pfam01108
      Location:29 → 126
      Tissue_fac; Tissue factor
      pfam09294
      Location:138 → 242
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    2. XM_011243169.2 → XP_011241471.1  interleukin-20 receptor subunit alpha isoform X3

      Conserved Domains (1) summary
      pfam09294
      Location:25 → 128
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    3. XM_006512729.2 → XP_006512792.1  interleukin-20 receptor subunit alpha isoform X2

      See identical proteins and their annotated locations for XP_006512792.1

      Conserved Domains (1) summary
      pfam09294
      Location:4 → 108
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    4. XM_006512728.5 → XP_006512791.1  interleukin-20 receptor subunit alpha isoform X2

      See identical proteins and their annotated locations for XP_006512791.1

      Conserved Domains (1) summary
      pfam09294
      Location:4 → 108
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PHB0.2 GenPept UniProtKB/Swiss-Prot:Q6PHB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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