Lpo lactoperoxidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpoprovided by MGI
Official Full Name: lactoperoxidaseprovided by MGI
Primary source: MGI:MGI:1923363
See related: Ensembl:ENSMUSG00000009356 AllianceGenome:MGI:1923363
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5830499B15Rik
Summary: Enables peroxidase activity. Predicted to be involved in defense response to bacterium and detection of chemical stimulus involved in sensory perception of bitter taste. Located in cytoplasm. Orthologous to human LPO (lactoperoxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward colon adult (RPKM 60.4) See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 52.22 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (87697254..87716750, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (87806428..87826114, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice.
Title: Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice.
we postulate that Lpo upregulation in the intestinal epithelium of miR-10a deficient mice together with the predominant abundance of estrogens in female animals mainly accounts for the sex-related cancer phenotype we observed
Title: Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice.
methylation of the Lpo intragenic CpG island was not directly induced by inflammation, because dextran sulfate sodium-induced colitis did not increase DNA methylation in B6 DKO colon. Also, Lpo DNA methylation is not correlated with gene expression
Title: Expression of lactoperoxidase in differentiated mouse colon epithelial cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2)

General gene information

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Markers

MHAa67g9.seq (e-PCR)
- UniSTS:125281

Lpo (e-PCR), detects polymorphism
- UniSTS:507034

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables lactoperoxidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables thiocyanate peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiocyanate peroxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular oxidant detoxification	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lactoperoxidase

NP_536345.2

EC 1.11.1.7

XP_011247600.1

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080420.3 → NP_536345.2 lactoperoxidase precursor

See identical proteins and their annotated locations for NP_536345.2

Status: VALIDATED

Source sequence(s)

AL604022, AL606805

Consensus CDS

CCDS25218.1

UniProtKB/Swiss-Prot

Q5SW46

UniProtKB/TrEMBL

Q91WA0

Related

ENSMUSP00000099466.4, ENSMUST00000103177.10

Conserved Domains (1) summary

cd09824
Location:281 → 692

myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

87697254..87716750 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249298.4 → XP_011247600.1 lactoperoxidase isoform X1

See identical proteins and their annotated locations for XP_011247600.1

UniProtKB/Swiss-Prot

Q5SW46

UniProtKB/TrEMBL

Q91WA0

Conserved Domains (1) summary

cd09824
Location:281 → 692

myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases