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    Crispld1 cysteine-rich secretory protein LCCL domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 83691, updated on 12-May-2024

    Summary

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    Official Symbol
    Crispld1provided by MGI
    Official Full Name
    cysteine-rich secretory protein LCCL domain containing 1provided by MGI
    Primary source
    MGI:MGI:1934666
    See related
    Ensembl:ENSMUSG00000025776 AllianceGenome:MGI:1934666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lcrisp1; Cocoacrisp
    Summary
    Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including axial skeleton; bone; meninges; nose; and respiratory system. Orthologous to human CRISPLD1 (cysteine rich secretory protein LCCL domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in limb E14.5 (RPKM 4.2), CNS E11.5 (RPKM 1.9) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 A3; 1 5.32 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (17797276..17840350)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (17727029..17767235)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00362 Neighboring gene STARR-seq mESC enhancer starr_00364 Neighboring gene predicted gene, 25166 Neighboring gene predicted gene 28154 Neighboring gene peptidase inhibitor 15 Neighboring gene STARR-seq mESC enhancer starr_00366 Neighboring gene predicted gene 16070 Neighboring gene STARR-seq mESC enhancer starr_00368 Neighboring gene high mobility group box transcription factor 1 pseudogene Neighboring gene NLR family, pyrin domain containing 4F pseudogene Neighboring gene centromere protein E pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A six-gene expression toolbox for the glands, epithelium and chondrocytes in the mouse nasal cavity. Wan Y, et al. Gene Expr Patterns, 2018 Jan. PMID 29122676
    2. Functional screen identifies regulators of murine hematopoietic stem cell repopulation. Holmfeldt P, et al. J Exp Med, 2016 Mar 7. PMID 26880577, Free PMC Article
    3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich secretory protein LCCL domain-containing 1
    Names
    LCCL domain containing cysteine-rich secretory protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356551.2 → NP_001343480.1  cysteine-rich secretory protein LCCL domain-containing 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC104917, AC105075
      Consensus CDS
      CCDS35519.1
      UniProtKB/Swiss-Prot
      Q8CGD2, Q8K018, Q99MM6
      Related
      ENSMUSP00000124095.2, ENSMUST00000159958.8
      Conserved Domains (3) summary
      smart00603
      Location:291 → 375
      LCCL; LCCL domain
      cd18813
      Location:62 → 207
      CAP_CRISPLD1; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1
      pfam03815
      Location:394 → 492
      LCCL; LCCL domain

    2. NM_001421149.1 → NP_001408078.1  cysteine-rich secretory protein LCCL domain-containing 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC104917, AC105075
      UniProtKB/Swiss-Prot
      Q8CGD2, Q8K018, Q99MM6

    3. NM_031402.3 → NP_113579.2  cysteine-rich secretory protein LCCL domain-containing 1 precursor

      See identical proteins and their annotated locations for NP_113579.2

      Status: VALIDATED

      Source sequence(s)
      AC104917, AC105075
      Consensus CDS
      CCDS35519.1
      UniProtKB/Swiss-Prot
      Q8CGD2, Q8K018, Q99MM6
      Related
      ENSMUSP00000092686.5, ENSMUST00000095075.5
      Conserved Domains (3) summary
      smart00603
      Location:291 → 375
      LCCL; LCCL domain
      cd18813
      Location:62 → 207
      CAP_CRISPLD1; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1
      pfam03815
      Location:394 → 492
      LCCL; LCCL domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      17797276..17840350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495594.5 → XP_006495657.1  cysteine-rich secretory protein LCCL domain-containing 1 isoform X2

      Conserved Domains (3) summary
      smart00603
      Location:190 → 274
      LCCL; LCCL domain
      pfam03815
      Location:293 → 391
      LCCL; LCCL domain
      cl00133
      Location:2 → 106
      CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family

    2. XM_011238410.3 → XP_011236712.1  cysteine-rich secretory protein LCCL domain-containing 1 isoform X3

      Conserved Domains (2) summary
      smart00603
      Location:105 → 189
      LCCL; LCCL domain
      pfam03815
      Location:208 → 306
      LCCL; LCCL domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGD2.1 GenPept UniProtKB/Swiss-Prot:Q8CGD2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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