Abcc3 ATP-binding cassette, sub-family C member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abcc3provided by MGI
Official Full Name: ATP-binding cassette, sub-family C member 3provided by MGI
Primary source: MGI:MGI:1923658
See related: Ensembl:ENSMUSG00000020865 AllianceGenome:MGI:1923658
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MLP2; MRP3; ABC31; MOAT-D; 1700019L09Rik
Summary: Predicted to enable ABC-type transporter activity; glucuronoside transmembrane transporter activity; and icosanoid transmembrane transporter activity. Predicted to be involved in anion transport and xenobiotic transmembrane transport. Predicted to act upstream of or within canalicular bile acid transport. Located in basolateral plasma membrane. Is integral component of plasma membrane. Is expressed in alimentary system; liver; and small intestine. Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 63.1), colon adult (RPKM 54.5) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 58.9 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (94234121..94283843, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (94343295..94393017, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abbcc3 knock-out mice have enhanced platelet response to clopidogrel due to increased formation of clopidogral active metabolite.
Title: Enhanced Platelet Response to Clopidogrel in Abcc3-deficient Mice Due to Its Increased Bioactivation.
data show that this transporter activity is involved in ABCC3-induced senescence, demonstrating that this protein has a complex role in cancer, since its loss of function may promote escape from OIS and tumor formation
Title: Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape.
Transport of cefadroxil by ABCC3 and ABCC4 was saturable with K(m) values of 2.5 +/- 0.7 and 0.25 +/- 0.07 mM, respectively.
Title: Oral availability of cefadroxil depends on ABCC3 and ABCC4.
role of the bile acid membrane transporter Mrp3 (Abcc3), which is expressed in the liver and gut, in the hepatic growth response elicited by bile acids and in liver regeneration after partial hepatectomy
Title: Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice.
Both Abcc2 and Abcc3 significantly influenced the PK properties of MTX.
Title: Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models.
InsP(3)R2-mediated Ca(2+) signals enhance organic anion secretion into bile by targeting Mrp2 to the canalicular membrane.
Title: Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver.
Data show that Abcc2, Abcc3, and Abcg2 together mediate the rapid elimination of MTX and 7OH-MTX.
Title: Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo.
These results suggest that Mrp3 plays major roles in the efflux transport of various glucuronide conjugates from the enterocytes to the portal blood in the small intestine together with unknown transporter(s)
Title: Functional characterization of multidrug resistance-associated protein 3 (mrp3/abcc3) in the basolateral efflux of glucuronide conjugates in the mouse small intestine.
Complex pharmacokinetic behavior of ezetimibe depends on intestinal abcc2, abcc3, and abcg2.
Title: Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2.
Report Role of hepatic Mrp3 transporter in prevention of bile acid toxicity after partial hepatectomy in mice.
Title: Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

RH136225 (e-PCR)
- UniSTS:210219

D17945 (e-PCR)
- UniSTS:124745

ha1563 (e-PCR)
- UniSTS:515450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type bile acid transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type glutathione S-conjugate transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glucuronoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables icosanoid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within canalicular bile acid transport	ISO Inferred from Sequence Orthology more info
involved_in leukotriene transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family C member 3

Names: ATP-binding cassette protein C3; ATP-binding cassette transporter; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2; multidrug resistance-associated protein 3; transporter

NP_001350116.1

EC 7.6.2.2

EC 7.6.2.3

NP_001350118.1

EC 7.6.2.2

EC 7.6.2.3

NP_083876.3

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363187.1 → NP_001350116.1 ATP-binding cassette sub-family C member 3 isoform 1

Status: VALIDATED

Source sequence(s)

AL645965

Consensus CDS

CCDS88225.1

UniProtKB/Swiss-Prot

B2RX12, J3QML2, Q3U1W8, Q56PH0, Q59DK9, Q59DL0, Q5SUF4, Q80ZK8

Related

ENSMUSP00000136343.2, ENSMUST00000178136.8

Conserved Domains (1) summary

TIGR00957
Location:7 → 1522

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
NM_001363189.1 → NP_001350118.1 ATP-binding cassette sub-family C member 3 isoform 3

Status: VALIDATED

Source sequence(s)

AL645965

Conserved Domains (1) summary

cl26602
Location:7 → 1497

SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
NM_029600.4 → NP_083876.3 ATP-binding cassette sub-family C member 3 isoform 2

See identical proteins and their annotated locations for NP_083876.3

Status: VALIDATED

Source sequence(s)

AK149551, AL645965

Consensus CDS

CCDS25254.1

UniProtKB/TrEMBL

A0A0R4J015

Related

ENSMUSP00000021231.8, ENSMUST00000021231.8

Conserved Domains (5) summary

TIGR00957
Location:7 → 1521

MRP_assoc_pro; multi drug resistance-associated protein (MRP)

cd03244
Location:1282 → 1502

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:626 → 827

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

pfam00664
Location:976 → 1235

ABC_membrane; ABC transporter transmembrane region

cl00549
Location:316 → 577

ABC_membrane; ABC transporter transmembrane region