Cep63 centrosomal protein 63 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cep63provided by MGI
Official Full Name: centrosomal protein 63provided by MGI
Primary source: MGI:MGI:2158560
See related: Ensembl:ENSMUSG00000032534 AllianceGenome:MGI:2158560
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ET2; CD20R; D9Mgc41; D9Mgc48e; 4921501M07; AL450317.13gm1
Summary: This gene encodes a subunit of the centrosome, the main microtubule-organizing center of the cell. The encoded protein associates with another centrosomal protein, CEP152, to regulate mother-centriole-dependent centriole duplication in dividing cells. Disruption of a similar gene in human has been associated with primary microcephaly (MCPH). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression: Biased expression in testis adult (RPKM 38.6), CNS E11.5 (RPKM 4.6) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 54.61 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (102461784..102503748, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (102586578..102626564, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that IL-20-receptor signaling delimits IL-17 production in psoriatic inflammation
Title: IL-20-Receptor Signaling Delimits IL-17 Production in Psoriatic Inflammation.
In brain development, Wdr62 and Aspm localize to the proximal end of the mother centriole and interact physically, with Wdr62 required for Aspm localization, and both proteins, as well as microcephaly protein Cep63, required to localize CENPJ/CPAP/Sas-4, a final common target.
Title: Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.
Cep63-deficient mice recapitulate Seckel syndrome pathology, microcephaly and dwarfism. Cep63 loss severely impairs meiotic recombination, leading to profound male infertility.
Title: CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.
both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation.
Title: Cep63 and cep152 cooperate to ensure centriole duplication.
Cep63 regulates mother-centriole-dependent centriole duplication.
Title: The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mgc41 (e-PCR), detects polymorphism
- UniSTS:142783

D9Mgc47e (e-PCR), detects polymorphism
- UniSTS:142789

D9Mgc48e (e-PCR), detects polymorphism
- UniSTS:142790

AW107703 (e-PCR)
- UniSTS:179960

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in centriole replication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centriole replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of intrinsic apoptotic signaling pathway by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within meiotic telomere clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: centrosomal protein of 63 kDa

Names: centrosome protein Cep63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081122.2 → NP_001074591.1 centrosomal protein of 63 kDa isoform 1

See identical proteins and their annotated locations for NP_001074591.1

Status: REVIEWED

Source sequence(s)

AL450317, CT573150

Consensus CDS

CCDS40743.1

UniProtKB/TrEMBL

F8VPJ7

Related

ENSMUSP00000091306.4, ENSMUST00000093791.10

Conserved Domains (1) summary

pfam17045
Location:76 → 338

CEP63; Centrosomal protein of 63 kDa
NM_001301689.2 → NP_001288618.1 centrosomal protein of 63 kDa isoform 2

See identical proteins and their annotated locations for NP_001288618.1

Status: REVIEWED

Source sequence(s)

AL450317, CT573150

Consensus CDS

CCDS90650.1

UniProtKB/TrEMBL

U5KVR9

Related

ENSMUSP00000149157.2, ENSMUST00000216281.2

Conserved Domains (1) summary

pfam17045
Location:76 → 338

CEP63; Centrosomal protein of 63 kDa
NM_001407699.1 → NP_001394628.1 centrosomal protein of 63 kDa isoform 3

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407700.1 → NP_001394629.1 centrosomal protein of 63 kDa isoform 4

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407701.1 → NP_001394630.1 centrosomal protein of 63 kDa isoform 5

Status: REVIEWED

Source sequence(s)

AL450317, CT573150

UniProtKB/Swiss-Prot

Q3UPP8, Q80ZM0
NM_001407702.1 → NP_001394631.1 centrosomal protein of 63 kDa isoform 5

Status: REVIEWED

Source sequence(s)

AL450317, CT573150

UniProtKB/Swiss-Prot

Q3UPP8, Q80ZM0
NM_001407703.1 → NP_001394632.1 centrosomal protein of 63 kDa isoform 6

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407704.1 → NP_001394633.1 centrosomal protein of 63 kDa isoform 7

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407705.1 → NP_001394634.1 centrosomal protein of 63 kDa isoform 8

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407706.1 → NP_001394635.1 centrosomal protein of 63 kDa isoform 9

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407707.1 → NP_001394636.1 centrosomal protein of 63 kDa isoform 10

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407708.1 → NP_001394637.1 centrosomal protein of 63 kDa isoform 11

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407709.1 → NP_001394638.1 centrosomal protein of 63 kDa isoform 12

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407710.1 → NP_001394639.1 centrosomal protein of 63 kDa isoform 13

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407711.1 → NP_001394640.1 centrosomal protein of 63 kDa isoform 14

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407712.1 → NP_001394641.1 centrosomal protein of 63 kDa isoform 14

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407713.1 → NP_001394642.1 centrosomal protein of 63 kDa isoform 14

Status: REVIEWED

Source sequence(s)

AL450317, CT573150

Related

ENSMUSP00000125621.2, ENSMUST00000162655.9
NM_001407714.1 → NP_001394643.1 centrosomal protein of 63 kDa isoform 15

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407715.1 → NP_001394644.1 centrosomal protein of 63 kDa isoform 15

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407716.1 → NP_001394645.1 centrosomal protein of 63 kDa isoform 16

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407717.1 → NP_001394646.1 centrosomal protein of 63 kDa isoform 16

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407718.1 → NP_001394647.1 centrosomal protein of 63 kDa isoform 17

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407719.1 → NP_001394648.1 centrosomal protein of 63 kDa isoform 18

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407720.1 → NP_001394649.1 centrosomal protein of 63 kDa isoform 19

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407721.1 → NP_001394650.1 centrosomal protein of 63 kDa isoform 20

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407722.1 → NP_001394651.1 centrosomal protein of 63 kDa isoform 21

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NM_001407723.1 → NP_001394652.1 centrosomal protein of 63 kDa isoform 22

Status: REVIEWED

Source sequence(s)

AL450317, CT573150

RNA

NR_176403.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NR_176404.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NR_176405.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NR_176406.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NR_176407.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NR_176408.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NR_176409.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NR_176410.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL450317, CT573150
NR_176411.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL450317, CT573150

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

102461784..102503748 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511747.5 → XP_006511810.1 centrosomal protein of 63 kDa isoform X15

Conserved Domains (2) summary

TIGR02169
Location:145 → 498

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam17045
Location:18 → 239

CEP63; Centrosomal protein of 63 kDa
XM_036155044.1 → XP_036010937.1 centrosomal protein of 63 kDa isoform X12

Conserved Domains (2) summary

COG1196
Location:216 → 522

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam17045
Location:76 → 297

CEP63; Centrosomal protein of 63 kDa
XM_011242886.2 → XP_011241188.1 centrosomal protein of 63 kDa isoform X11

Conserved Domains (2) summary

TIGR02169
Location:224 → 577

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam17045
Location:97 → 318

CEP63; Centrosomal protein of 63 kDa
XM_017313406.1 → XP_017168895.1 centrosomal protein of 63 kDa isoform X1

Conserved Domains (2) summary

pfam15921
Location:102 → 667

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:97 → 359

CEP63; Centrosomal protein of 63 kDa
XM_011242890.3 → XP_011241192.1 centrosomal protein of 63 kDa isoform X16

Conserved Domains (2) summary

COG1196
Location:278 → 563

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam17045
Location:97 → 359

CEP63; Centrosomal protein of 63 kDa
XM_030244411.2 → XP_030100271.1 centrosomal protein of 63 kDa isoform X20

Conserved Domains (2) summary

TIGR02168
Location:139 → 485

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17045
Location:81 → 302

CEP63; Centrosomal protein of 63 kDa
XM_017313416.3 → XP_017168905.1 centrosomal protein of 63 kDa isoform X23

Conserved Domains (1) summary

pfam05483
Location:51 → 247

SCP-1; Synaptonemal complex protein 1 (SCP-1)
XM_011242885.3 → XP_011241187.1 centrosomal protein of 63 kDa isoform X9

Conserved Domains (2) summary

pfam15921
Location:53 → 635

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:70 → 332

CEP63; Centrosomal protein of 63 kDa
XM_017313407.2 → XP_017168896.1 centrosomal protein of 63 kDa isoform X4

Conserved Domains (2) summary

pfam15921
Location:91 → 656

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:86 → 348

CEP63; Centrosomal protein of 63 kDa
XM_017313408.2 → XP_017168897.1 centrosomal protein of 63 kDa isoform X6

Conserved Domains (2) summary

pfam15921
Location:46 → 646

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:81 → 343

CEP63; Centrosomal protein of 63 kDa
XM_017313411.3 → XP_017168900.1 centrosomal protein of 63 kDa isoform X17

Conserved Domains (2) summary

pfam15921
Location:46 → 577

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:81 → 343

CEP63; Centrosomal protein of 63 kDa
XM_006511744.4 → XP_006511807.1 centrosomal protein of 63 kDa isoform X13

See identical proteins and their annotated locations for XP_006511807.1

Conserved Domains (2) summary

TIGR02169
Location:202 → 555

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam17045
Location:34 → 296

CEP63; Centrosomal protein of 63 kDa
XM_011242882.3 → XP_011241184.1 centrosomal protein of 63 kDa isoform X3

Conserved Domains (2) summary

pfam15921
Location:97 → 662

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:92 → 354

CEP63; Centrosomal protein of 63 kDa
XM_011242883.3 → XP_011241185.1 centrosomal protein of 63 kDa isoform X5

Conserved Domains (2) summary

pfam15921
Location:90 → 655

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:85 → 347

CEP63; Centrosomal protein of 63 kDa
XM_006511739.3 → XP_006511802.1 centrosomal protein of 63 kDa isoform X2

Conserved Domains (2) summary

pfam15921
Location:101 → 666

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:96 → 358

CEP63; Centrosomal protein of 63 kDa
XM_011242884.3 → XP_011241186.1 centrosomal protein of 63 kDa isoform X7

Conserved Domains (2) summary

pfam15921
Location:86 → 651

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:81 → 343

CEP63; Centrosomal protein of 63 kDa