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    CDC25C cell division cycle 25C [ Homo sapiens (human) ]

    Gene ID: 995, updated on 3-Apr-2024

    Summary

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    Official Symbol
    CDC25Cprovided by HGNC
    Official Full Name
    cell division cycle 25Cprovided by HGNC
    Primary source
    HGNC:HGNC:1727
    See related
    Ensembl:ENSG00000158402 MIM:157680; AllianceGenome:HGNC:1727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC25; PPP1R60
    Summary
    This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]
    Expression
    Biased expression in testis (RPKM 7.7), bone marrow (RPKM 1.3) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    5q31.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (138285265..138338355, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (138811484..138864572, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137620954..137674044, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene kinesin family member 20A Neighboring gene cell division cycle 23 Neighboring gene Sharpr-MPRA regulatory region 7870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137581186-137581778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23196 Neighboring gene MPRA-validated peak5491 silencer Neighboring gene MPRA-validated peak5492 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16388 Neighboring gene GDNF family receptor alpha 3 Neighboring gene RPS27A pseudogene 18 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:137642973-137643148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:137666651-137667604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16389 Neighboring gene uncharacterized LOC100128966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16393 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23201 Neighboring gene family with sequence similarity 53 member C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137706464-137706964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137706965-137707465 Neighboring gene lysine demethylase 3B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137775379-137775912 Neighboring gene receptor accessory protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma. Zhou C, et al. Bioengineered, 2022 May. PMID 35615982, Free PMC Article
    2. Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer. Topno R, et al. Cancer Biomark, 2021. PMID 34275890
    3. Identification of CDC25C as a Potential Biomarker in Hepatocellular Carcinoma Using Bioinformatics Analysis. Xun R, et al. Technol Cancer Res Treat, 2020 Jan-Dec. PMID 33111630, Free PMC Article
    4. CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival. Galusic D, et al. Wien Klin Wochenschr, 2022 Jan. PMID 32945945
    5. Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation. Liu K, et al. Med Oncol, 2019 Nov 16. PMID 31734829

    See all (238) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C.
      Title: PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C.
    2. CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma.
      Title: CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma.
    3. Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer.
      Title: Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer.
    4. CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival.
      Title: CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival.
    5. Identification of Prognostic Genes for Colon Cancer through Gene Co-expression Network Analysis.
      Title: Identification of Prognostic Genes for Colon Cancer through Gene Co-expression Network Analysis.
    6. Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.
      Title: Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.
    7. Identification of CDC25C as a Potential Biomarker in Hepatocellular Carcinoma Using Bioinformatics Analysis.
      Title: Identification of CDC25C as a Potential Biomarker in Hepatocellular Carcinoma Using Bioinformatics Analysis.
    8. BTNL9 is frequently downregulated and inhibits proliferation and metastasis via the P53/CDC25C and P53/GADD45 pathways in breast cancer.
      Title: BTNL9 is frequently downregulated and inhibits proliferation and metastasis via the P53/CDC25C and P53/GADD45 pathways in breast cancer.
    9. Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells.
      Title: Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells.
    10. Studied p38MAPK-ERK-JNK-cell division cycle 25C (CDC25C) expression in polyploid giant cancer cells and clinicopathological significance of p38MAPK, ERK, JNK, and CDC25C expression in human ovarian and breast cancers.
      Title: Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation.
    Submit: New GeneRIF Correction See all GeneRIFs (90)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 decreases adult neural progenitor cell proliferation via the p38 MAPK-MAPKAPK2-Cdc25C signaling pathway PubMed
    Tat tat The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells PubMed
    Vpr vpr Kinase Srk1 is required for the Vpr-mediated nuclear export of Cdc25 PubMed
    vpr HIV-1 Vpr induces subcellular relocalization of Cdc25 from nuclear to cytoplasm and Vpr-induced nuclear exclusion of Cdc25 depends on the serine/threonine phosphorylation of Cdc25 and the presence of Rad24/14-3-3 protein PubMed
    vpr Vpr-induced cell cycle G2/M arrest reveals a dramatic increase in the amount of Cdk1, Cdc25C, and CyclinB1 bound to 14-3-3 theta PubMed
    vpr Binding of Cdc25c to HIV-1 Vpr is required for Vpr-mediated G2 arrest in HeLa cells PubMed
    vpr A minimal domain between amino acids 334 and 379 of Cdc25c, upstream of its catalytic site, is sufficient to bind HIV-1 Vpr; mutation at residue E352 of Cdc25c greatly reduces binding of Vpr to Cdc25c PubMed
    vpr HIV-1 Vpr forms a triple complex with 14-3-3 eta and Cdc25C and thereby promotes cell cycle arrest at the G(2)/M phase by facilitating association of 14-3-3 and Cdc25C PubMed
    vpr Rupture of HIV-1 Vpr-induced nuclear envelope herniations produces transient loss of the subcellular compartmentalization of Wee1, Cdc25C, cyclin B1, and presumably other soluble cellular components, resulting in their release into the cytoplasm PubMed
    vpr The human Vpr interacting protein (hVIP/MOV34) is a likely cellular cofactor for HIV-1 Vpr inactivation of the cdc2-cyclin B kinase complex through Cdc25c and induction of cell cycle arrest PubMed
    vpr Inactivation of the cdc2-cyclin B kinase complex through Cdc25c and arrest in the G2 phase of the cell cycle has been mapped to the C-terminus of HIV-1 Vpr, including amino acids 73, 80 and 84-96 PubMed
    vpr HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inactivating cdc25C, the phosphatase that dephosphorylates and activates cdc2 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables WW domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    M-phase inducer phosphatase 3
    Names
    CDC25 homolog C
    dual specificity phosphatase CDC25C
    mitosis inducer CDC25
    phosphotyrosine phosphatase
    protein phosphatase 1, regulatory subunit 60
    NP_001274511.1
    NP_001274512.1
    NP_001305027.1
    NP_001350955.1
    NP_001350956.1
    NP_001350957.1
    NP_001781.2
    NP_073720.1
    XP_005272202.1
    XP_006714802.1
    XP_011542061.1
    XP_011542062.1
    XP_011542063.1
    XP_011542065.1
    XP_047273908.1
    XP_047273909.1
    XP_047273910.1
    XP_054209896.1
    XP_054209897.1
    XP_054209898.1
    XP_054209899.1
    XP_054209900.1
    XP_054209901.1
    XP_054209902.1
    XP_054209903.1
    XP_054209904.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287582.2 → NP_001274511.1  M-phase inducer phosphatase 3 isoform a

      See identical proteins and their annotated locations for NP_001274511.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AK097710, AU125025, AW512559, BC019089, DB449713
      Consensus CDS
      CCDS4202.1
      UniProtKB/Swiss-Prot
      D3DQB8, P30307, Q96PL3, Q9H168, Q9H2E8, Q9H2E9, Q9H2F1
      UniProtKB/TrEMBL
      B4DX61
      Related
      ENSP00000425470.1, ENST00000514555.5
      Conserved Domains (2) summary
      cd01530
      Location:302 → 421
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:210 → 244
      M-inducer_phosp; M-phase inducer phosphatase

    2. NM_001287583.2 → NP_001274512.1  M-phase inducer phosphatase 3 isoform c

      See identical proteins and their annotated locations for NP_001274512.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate splice site in the 5' region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (c) has a longer N-terminus than isoform a.
      Source sequence(s)
      AK097710, AW512559, DB516402
      UniProtKB/TrEMBL
      B4DX61
      Conserved Domains (2) summary
      cd01530
      Location:380 → 499
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:288 → 322
      M-inducer_phosp; M-phase inducer phosphatase

    3. NM_001318098.2 → NP_001305027.1  M-phase inducer phosphatase 3 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (e) has a longer N-terminus than isoform 1.
      Source sequence(s)
      AK097710, AK301828, AW512559, BC019089
      UniProtKB/TrEMBL
      B4DX61
      Conserved Domains (2) summary
      cd01530
      Location:319 → 438
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:227 → 261
      M-inducer_phosp; M-phase inducer phosphatase

    4. NM_001364026.1 → NP_001350955.1  M-phase inducer phosphatase 3 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC104116
      UniProtKB/TrEMBL
      B4DX61
      Conserved Domains (2) summary
      COG5105
      Location:222 → 504
      MIH1; Mitotic inducer, protein phosphatase [Cell division and chromosome partitioning]
      cd01530
      Location:367 → 478
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

    5. NM_001364027.1 → NP_001350956.1  M-phase inducer phosphatase 3 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC104116
      UniProtKB/TrEMBL
      B4DX61
      Conserved Domains (2) summary
      COG5105
      Location:144 → 413
      MIH1; Mitotic inducer, protein phosphatase [Cell division and chromosome partitioning]
      cd01530
      Location:268 → 387
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

    6. NM_001364028.1 → NP_001350957.1  M-phase inducer phosphatase 3 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC104116
      UniProtKB/TrEMBL
      B4DX61
      Conserved Domains (2) summary
      COG5105
      Location:36 → 404
      MIH1; Mitotic inducer, protein phosphatase [Cell division and chromosome partitioning]
      cd01530
      Location:259 → 378
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

    7. NM_001790.5 → NP_001781.2  M-phase inducer phosphatase 3 isoform a

      See identical proteins and their annotated locations for NP_001781.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AC104116, AW512559, DB040755, M34065
      Consensus CDS
      CCDS4202.1
      UniProtKB/Swiss-Prot
      D3DQB8, P30307, Q96PL3, Q9H168, Q9H2E8, Q9H2E9, Q9H2F1
      UniProtKB/TrEMBL
      B4DX61
      Related
      ENSP00000321656.6, ENST00000323760.11
      Conserved Domains (2) summary
      cd01530
      Location:302 → 421
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:210 → 244
      M-inducer_phosp; M-phase inducer phosphatase

    8. NM_022809.4 → NP_073720.1  M-phase inducer phosphatase 3 isoform b

      See identical proteins and their annotated locations for NP_073720.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as cdc25Cdm) lacks three exons in the 5' coding region, resulting in a short region of frameshift, compared to variant 4. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC104116, AJ304504, AU098899, AW512559
      Consensus CDS
      CCDS4203.1
      UniProtKB/TrEMBL
      B4DX61
      Related
      ENSP00000392631.2, ENST00000415130.6
      Conserved Domains (2) summary
      cd01530
      Location:229 → 348
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:137 → 171
      M-inducer_phosp; M-phase inducer phosphatase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      138285265..138338355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417954.1 → XP_047273910.1  M-phase inducer phosphatase 3 isoform X8

    2. XM_006714739.4 → XP_006714802.1  M-phase inducer phosphatase 3 isoform X5

      UniProtKB/TrEMBL
      B4DX61
      Conserved Domains (2) summary
      cd01530
      Location:304 → 423
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:212 → 246
      M-inducer_phosp; M-phase inducer phosphatase

    3. XM_047417953.1 → XP_047273909.1  M-phase inducer phosphatase 3 isoform X7

    4. XM_011543761.3 → XP_011542063.1  M-phase inducer phosphatase 3 isoform X4

      UniProtKB/TrEMBL
      B4DX61
      Conserved Domains (2) summary
      cd01530
      Location:307 → 426
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:215 → 249
      M-inducer_phosp; M-phase inducer phosphatase

    5. XM_011543760.3 → XP_011542062.1  M-phase inducer phosphatase 3 isoform X3

      UniProtKB/TrEMBL
      B4DX61
      Conserved Domains (2) summary
      cd01530
      Location:333 → 444
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:288 → 322
      M-inducer_phosp; M-phase inducer phosphatase

    6. XM_005272145.4 → XP_005272202.1  M-phase inducer phosphatase 3 isoform X1

      UniProtKB/TrEMBL
      B4DX61
      Conserved Domains (2) summary
      cd01530
      Location:346 → 465
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:288 → 322
      M-inducer_phosp; M-phase inducer phosphatase

    7. XM_011543759.4 → XP_011542061.1  M-phase inducer phosphatase 3 isoform X2

      UniProtKB/TrEMBL
      B4DX61
      Conserved Domains (2) summary
      cd01530
      Location:326 → 445
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:234 → 268
      M-inducer_phosp; M-phase inducer phosphatase

    8. XM_047417952.1 → XP_047273908.1  M-phase inducer phosphatase 3 isoform X6

      UniProtKB/Swiss-Prot
      D3DQB8, P30307, Q96PL3, Q9H168, Q9H2E8, Q9H2E9, Q9H2F1
      Related
      ENSP00000424795.1, ENST00000513970.5

    9. XM_011543763.2 → XP_011542065.1  M-phase inducer phosphatase 3 isoform X9

      Conserved Domains (2) summary
      cd01530
      Location:191 → 310
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:99 → 133
      M-inducer_phosp; M-phase inducer phosphatase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      138811484..138864572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353928.1 → XP_054209903.1  M-phase inducer phosphatase 3 isoform X8

    2. XM_054353925.1 → XP_054209900.1  M-phase inducer phosphatase 3 isoform X5

    3. XM_054353927.1 → XP_054209902.1  M-phase inducer phosphatase 3 isoform X7

    4. XM_054353924.1 → XP_054209899.1  M-phase inducer phosphatase 3 isoform X4

    5. XM_054353923.1 → XP_054209898.1  M-phase inducer phosphatase 3 isoform X3

    6. XM_054353921.1 → XP_054209896.1  M-phase inducer phosphatase 3 isoform X1

    7. XM_054353922.1 → XP_054209897.1  M-phase inducer phosphatase 3 isoform X2

    8. XM_054353926.1 → XP_054209901.1  M-phase inducer phosphatase 3 isoform X6

      UniProtKB/Swiss-Prot
      D3DQB8, P30307, Q96PL3, Q9H168, Q9H2E8, Q9H2E9, Q9H2F1

    9. XM_054353929.1 → XP_054209904.1  M-phase inducer phosphatase 3 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30307.2 GenPept UniProtKB/Swiss-Prot:P30307

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