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    Atp6v0b ATPase, H+ transporting, lysosomal V0 subunit B [ Mus musculus (house mouse) ]

    Gene ID: 114143, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Atp6v0bprovided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V0 subunit Bprovided by MGI
    Primary source
    MGI:MGI:1890510
    See related
    Ensembl:ENSMUSG00000033379 AllianceGenome:MGI:1890510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atp6f; VMA16; 2310024H13Rik
    Summary
    Predicted to enable P-type proton-exporting transporter activity. Predicted to act upstream of or within proton transmembrane transport. Located in endosome. Is integral component of membrane. Is expressed in several structures, including genitourinary system; liver; nervous system; nose; and spleen. Orthologous to human ATP6V0B (ATPase H+ transporting V0 subunit b). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 210.8), adrenal adult (RPKM 164.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D1; 4 53.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117741523..117744548, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117884330..117887333, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Neighboring gene coiled-coil domain containing 24 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 Neighboring gene predicted gene, 40233 Neighboring gene predicted gene 12841 Neighboring gene STARR-positive B cell enhancer ABC_E4652 Neighboring gene DPH2 homolog Neighboring gene importin 13 Neighboring gene STARR-positive B cell enhancer ABC_E10251

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interferon-inducible transmembrane proteins of the innate immune response act as membrane organizers by influencing clathrin and v-ATPase localization and function. Wee YS, et al. Innate Immun, 2012 Dec. PMID 22467717
    2. Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase. Sun-Wada GH, et al. Gene, 2001 Aug 22. PMID 11675001
    3. Expression and localization of the mouse homologue of the yeast V-ATPase 21-kDa Subunit c" (Vma16p). Nishi T, et al. J Biol Chem, 2001 Sep 7. PMID 11441017
    4. Expression and function of the mouse V-ATPase d subunit isoforms. Nishi T, et al. J Biol Chem, 2003 Nov 21. PMID 12963731
    5. Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31. Mburu P, et al. Nat Genet, 2003 Aug. PMID 12833159

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables P-type proton-exporting transporter activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proton transmembrane transport ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting V-type ATPase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting V-type ATPase, V0 domain ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    part_of proton-transporting two-sector ATPase complex, proton-transporting domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transmembrane transporter complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase complex ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    V-type proton ATPase 21 kDa proteolipid subunit c''
    Names
    23 kDa subunit of V-ATPase
    ATPase, H+ transporting, V0 subunit B
    ATPase, H+ transporting, lysosomal (vacuolar proton pump)
    ATPase, H+ transporting, lysosomal 21kDa, V0 subunit B
    V-ATPase 21 kDa proteolipid subunit
    V-ATPase 21 kDa proteolipid subunit c''
    V-type proton ATPase 21 kDa proteolipid subunit
    lysosomal 21kDa
    vacuolar proton pump 21 kDa proteolipid subunit
    vacuolar proton pump 21 kDa proteolipid subunit c''
    NP_001406271.1
    NP_291095.1
    XP_030108954.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419342.1 → NP_001406271.1  V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627128
      UniProtKB/TrEMBL
      A0A0A0MQJ5
      Related
      ENSMUSP00000119988.3, ENSMUST00000150204.8

    2. NM_033617.4 → NP_291095.1  V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 1

      See identical proteins and their annotated locations for NP_291095.1

      Status: VALIDATED

      Source sequence(s)
      AL627128
      Consensus CDS
      CCDS18540.1
      UniProtKB/Swiss-Prot
      Q91V37
      UniProtKB/TrEMBL
      Q3U889, Q8JZR5
      Related
      ENSMUSP00000047682.8, ENSMUST00000036380.14
      Conserved Domains (2) summary
      cd18177
      Location:49 → 111
      ATP-synt_Vo_c_ATP6F_rpt1; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins
      cd18178
      Location:133 → 197
      ATP-synt_Vo_c_ATP6F_rpt2; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins

    RNA

    1. NR_185061.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627128

    2. NR_185062.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627128

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      117741523..117744548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253094.2 → XP_030108954.1  V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQJ5
      Conserved Domains (2) summary
      cd18177
      Location:2 → 64
      ATP-synt_Vo_c_ATP6F_rpt1; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins
      cd18178
      Location:86 → 150
      ATP-synt_Vo_c_ATP6F_rpt2; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91V37.1 GenPept UniProtKB/Swiss-Prot:Q91V37

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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