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    Hebp1 heme binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 15199, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hebp1provided by MGI
    Official Full Name
    heme binding protein 1provided by MGI
    Primary source
    MGI:MGI:1333880
    See related
    Ensembl:ENSMUSG00000042770 AllianceGenome:MGI:1333880
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hebp; p22HBP
    Summary
    Enables heme binding activity. Predicted to act upstream of or within heme metabolic process. Located in cytosol. Orthologous to human HEBP1 (heme binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 81.5), liver adult (RPKM 79.6) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 G1; 6 65.93 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135114517..135145213, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135137519..135168215, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor, family C, group 5, member D Neighboring gene Hebp1R1 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_17563 Neighboring gene fucose mutarotase-like Neighboring gene Hebp1R3 erythroid cis-regulatory module Neighboring gene predicted gene, 22881 Neighboring gene Hebp1R2 erythroid cis-regulatory module Neighboring gene predicted gene, 34391 Neighboring gene predicted gene, 19434 Neighboring gene predicted gene, 36533

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury. Ock J, et al. Int J Biol Sci, 2023. PMID 37324943, Free PMC Article
    2. Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice. Yin GN. Investig Clin Urol, 2022 Jul. PMID 35796141, Free PMC Article
    3. Transcriptional profiling of mouse cavernous pericytes under high-glucose conditions: Implications for diabetic angiopathy. Yin GN, et al. Investig Clin Urol, 2021 Jan. PMID 33258327, Free PMC Article
    4. Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins. Micaelo NM, et al. J Mol Graph Model, 2010 Nov. PMID 20800521
    5. SOUL in mouse eyes is a new hexameric heme-binding protein with characteristic optical absorption, resonance Raman spectral, and heme-binding properties. Sato E, et al. Biochemistry, 2004 Nov 9. PMID 15518569

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury.
      Title: Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury.
    2. Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice.
      Title: Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice.
    3. Transcriptional profiling of mouse cavernous pericytes under high-glucose conditions: Implications for diabetic angiopathy.
      Title: Transcriptional profiling of mouse cavernous pericytes under high-glucose conditions: Implications for diabetic angiopathy.
    4. Results present a systematic molecular modeling study of the binding properties of murine and human p22HBP protein (heme-binding protein) with four tetrapyrrole ring systems belonging to the heme biosynthetic pathway.
      Title: Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins.
    5. mouse neutrophils, which like macrophages and dendritic cells express Fpr2, responded to human and mouse F2L in both calcium flux and chemotaxis assays
      Title: F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor.
    6. Characterization as a tetrapyrrole-binding protein
      Title: Characterization of a human and mouse tetrapyrrole-binding protein.
    7. The heme-binding properties and coordination structure of mouse liver p22HBP are distinct from those of SOUL protein, despite high sequence homology.
      Title: SOUL in mouse eyes is a new hexameric heme-binding protein with characteristic optical absorption, resonance Raman spectral, and heme-binding properties.
    8. analysis of murine P22HBP structure
      Title: The first structure from the SOUL/HBP family of heme-binding proteins, murine P22HBP.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within heme metabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    heme-binding protein 1
    Names
    p22 HBP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013546.3 → NP_038574.3  heme-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      AC131718, AI527209, AK008919, BY242687
      Consensus CDS
      CCDS20645.1
      UniProtKB/Swiss-Prot
      O88814, Q9R257
      UniProtKB/TrEMBL
      A0A140T8J4
      Related
      ENSMUSP00000042232.8, ENSMUST00000045855.9
      Conserved Domains (1) summary
      pfam04832
      Location:13 → 188
      SOUL; SOUL heme-binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      135114517..135145213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241224.3 → XP_011239526.1  heme-binding protein 1 isoform X1

      Conserved Domains (1) summary
      pfam04832
      Location:60 → 222
      SOUL; SOUL heme-binding protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R257.2 GenPept UniProtKB/Swiss-Prot:Q9R257

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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