Akip1 A kinase interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akip1provided by MGI
Official Full Name: A kinase interacting protein 1provided by MGI
Primary source: MGI:MGI:3041226
See related: Ensembl:ENSMUSG00000031023 AllianceGenome:MGI:3041226
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BCA3; ORF27; C11orf17; D7H11orf17; D930014E17Rik; ICRFP703B1614Q5.6
Summary: Acts upstream of or within substrate adhesion-dependent cell spreading. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in nucleoplasm. Is expressed in genitourinary system; hippocampus; submandibular gland; and trachea. Orthologous to human AKIP1 (A-kinase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 8.7), liver E14 (RPKM 7.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 57.44 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (109302885..109311393)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (109703678..109712186)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise.
Title: A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise.
A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling.
Title: A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling.
miR-320 plays an important role in regulating cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1 and inducing the mitochondrial apoptotic pathway.
Title: MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1.
BCA3 interacts with Rac1 and augments NF-kappaB signaling in vitro, but has no effect on RANKL-induced bone resorption in vivo.
Title: Breast cancer-associated gene 3 interacts with Rac1 and augments NF-κB signaling in vitro, but has no effect on RANKL-induced bone resorption in vivo.
AKIP1 overexpression does not influence cardiac remodelling in response to chronic cardiac stress, or heart failure development. AKIP1 does, however, reduce myocardial I/R injury through stabilization of the MPT pore.
Title: Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development.
Data indicate A-kinase interacting protein 1 (AKIP1) as a critical molecular regulator and a therapeutic control point for stress adaptation in the heart.
Title: A kinase interacting protein (AKIP1) is a key regulator of cardiac stress.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase-interacting protein 1

Names: A kinase (PRKA) interacting protein 1; PKA-interacting protein; breast cancer-associated gene 3 protein; proline-rich protein BCA3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.