Plxna2 plexin A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plxna2provided by MGI
Official Full Name: plexin A2provided by MGI
Primary source: MGI:MGI:107684
See related: Ensembl:ENSMUSG00000026640 AllianceGenome:MGI:107684
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OCT; Plxn2; PlexA2; mKIAA0463; 2810428A13Rik
Summary: Enables identical protein binding activity and semaphorin receptor activity. Involved in regulation of cell migration and semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including cerebellar granule cell precursor tangential migration; chordate embryonic development; and limb bud formation. Is integral component of plasma membrane. Is expressed in several structures, including genitourinary system; heart; lung; nervous system; and sensory organ. Orthologous to human PLXNA2 (plexin A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E14 (RPKM 20.1), whole brain E14.5 (RPKM 19.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 98.27 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (194302020..194499177)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (194619791..194816869)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLXNA2 as a candidate gene in patients with intellectual disability.
Title: PLXNA2 as a candidate gene in patients with intellectual disability.
Here, biochemical analysis of NgR1 function uncovered a physical complex with CRMP cytoplasmic mediators, and this led to appreciation of a role for PlexinA2 in concert with NgR1 after adult spinal cord trauma.
Title: Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma.
These findings implicate Semaphorin-6A - Plexin-A2/Plexin-A4 interactions in dorsal lateral geniculate nucleus axon guidance and in the spatiotemporal organization of guidepost cell populations in the mammalian subpallium.
Title: Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.
describe procedures for protein production and purification that we utilized in the crystallographic study of the mouse Plexin A2 (mPlxnA2) extracellular fragment, including the sema domain
Title: Immunoaffinity Purification of the Glycosylated Extracellular Fragment of Mouse Plexin A2 Produced in a Mammalian Expression System.
work reveals a 2-fold role of the PlxnA ectodomains: imposing a pre-signaling autoinhibitory separation for the cytoplasmic domains via intermolecular head-to-stalk interactions and supporting dimerization-based PlxnA activation upon ligand binding.
Title: Structural Basis for Plexin Activation and Regulation.
Using time-lapse videomicroscopy we provide evidence that Sema6A/PlexinA2 signaling participates to interkinetic nuclear migration of retinal progenitor cell
Title: PlexinA2 and Sema6A are required for retinal progenitor cell migration.
Plexin A2 is expressed in both On and Off starburst amacrine cell.
Title: On and off retinal circuit assembly by divergent molecular mechanisms.
results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 signaling
Title: PlexinA2 mediates osteoblast differentiation via regulation of Runx2.
crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1(1-2)-SEMA4D(ecto) and murine PlxnA2(1-4)-Sema6A(ecto)), plus unliganded structures of PlxnA2(1-4) and Sema6A(ecto)
Title: Structural basis of semaphorin-plexin signalling.
crystal structures of the semaphorin 6A (Sema6A) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states
Title: Structural basis for semaphorin signalling through the plexin receptor.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa97e12.seq (e-PCR)
- UniSTS:125464

NoName (e-PCR)
- UniSTS:234316

Plxna2 (e-PCR), detects polymorphism
- UniSTS:526941

AW457381 (e-PCR)
- UniSTS:178558

MARC_9713-9714:996688545:1 (e-PCR)
- UniSTS:269978

D13Got103 (e-PCR)
- UniSTS:112548

RH124958 (e-PCR)
- UniSTS:161780

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables semaphorin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables semaphorin receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar granule cell precursor tangential migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in limb bud formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural tube development	IEP Inferred from Expression Pattern more info	PubMed
involved_in pharyngeal system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somitogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plexin-A2

Names: plex 2; plexin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008882.2 → NP_032908.2 plexin-A2 precursor

See identical proteins and their annotated locations for NP_032908.2

Status: VALIDATED

Source sequence(s)

AA289826, AC162447, BC068155, BY753209, D86949

Consensus CDS

CCDS35827.1

UniProtKB/Swiss-Prot

P70207, Q6NVE6, Q6PHN4, Q80TZ7, Q8R1I4

Related

ENSMUSP00000027952.6, ENSMUST00000027952.12

Conserved Domains (7) summary

cd11272
Location:38 → 552

Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2

cd01179
Location:954 → 1037

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:858 → 953

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1041 → 1141

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:806 → 855

PSI; Plexin repeat

pfam01833
Location:1143 → 1227

TIG; IPT/TIG domain

pfam08337
Location:1311 → 1864

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

194302020..194499177

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497240.5 → XP_006497303.1 plexin-A2 isoform X1

Conserved Domains (9) summary

cd11272
Location:38 → 552

Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2

cd01179
Location:954 → 1037

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:858 → 953

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1041 → 1141

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:806 → 855

PSI; Plexin repeat

pfam01833
Location:1143 → 1227

TIG; IPT/TIG domain

pfam08337
Location:1311 → 1870

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:566 → 654

TIG_plexin; TIG domain

pfam18020
Location:708 → 802

TIG_2; TIG domain found in plexin
XM_036162782.1 → XP_036018675.1 plexin-A2 isoform X2

Conserved Domains (4) summary

cd11272
Location:38 → 552

Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2

pfam01437
Location:806 → 855

PSI; Plexin repeat

pfam17960
Location:565 → 654

TIG_plexin; TIG domain

pfam18020
Location:708 → 802

TIG_2; TIG domain found in plexin